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Lithium And Bone Healing

Date:
August 1, 2007
Source:
Public Library of Science
Summary:
New molecular pathway shown in bone healing that could be enhanced by lithium treatment.

Researchers have described a novel molecular pathway that may have a critical role in bone healing and have suggested that lithium, which affects this pathway, has the potential to improve fracture healing.

The study, led by Benjamin Alman from the Hospital For Sick Children, Toronto, investigated the role of the -catenin signaling pathway, which activates T cell factor -dependent gene transcription, and which is known to have a key regulatory role in embryonic skeletal development.

By studying mice with fractures the researchers were able to show that -catenin-mediated gene transcription was activated in both bone and cartilage formation during fracture repair. In mice that lacked -catenin fracture healing was inhibited, whereas in mice expressing an activated form of -catenin bone healing was accelerated.

Treating mice with lithium activated -catenin in the healing fracture, but healing was enhanced only when treatment was given after the fracture occurred, rather than before.

These results show that that -catenin functions differently at different stages of fracture repair. Although the relevance of this study to human fractures remains to be determined, activation of -catenin by lithium treatment has the potential to improve fracture healing, but probably only when given in later phases of fracture healing.

Citation: Chen Y, Whetstone HC, Lin AC, Nadesan P, Wei Q, et al. (2007) Beta-catenin signaling plays a disparate role in different phases of fracture repair: Implications for therapy to improve bone healing. PLoS Med 4(7): e249. http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040249


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Public Library of Science. "Lithium And Bone Healing." ScienceDaily. ScienceDaily, 1 August 2007. <www.sciencedaily.com/releases/2007/07/070730092341.htm>.
Public Library of Science. (2007, August 1). Lithium And Bone Healing. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2007/07/070730092341.htm
Public Library of Science. "Lithium And Bone Healing." ScienceDaily. www.sciencedaily.com/releases/2007/07/070730092341.htm (accessed September 23, 2014).

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