Featured Research

from universities, journals, and other organizations

Lithium And Bone Healing

Date:
August 1, 2007
Source:
Public Library of Science
Summary:
New molecular pathway shown in bone healing that could be enhanced by lithium treatment.

Researchers have described a novel molecular pathway that may have a critical role in bone healing and have suggested that lithium, which affects this pathway, has the potential to improve fracture healing.

The study, led by Benjamin Alman from the Hospital For Sick Children, Toronto, investigated the role of the -catenin signaling pathway, which activates T cell factor -dependent gene transcription, and which is known to have a key regulatory role in embryonic skeletal development.

By studying mice with fractures the researchers were able to show that -catenin-mediated gene transcription was activated in both bone and cartilage formation during fracture repair. In mice that lacked -catenin fracture healing was inhibited, whereas in mice expressing an activated form of -catenin bone healing was accelerated.

Treating mice with lithium activated -catenin in the healing fracture, but healing was enhanced only when treatment was given after the fracture occurred, rather than before.

These results show that that -catenin functions differently at different stages of fracture repair. Although the relevance of this study to human fractures remains to be determined, activation of -catenin by lithium treatment has the potential to improve fracture healing, but probably only when given in later phases of fracture healing.

Citation: Chen Y, Whetstone HC, Lin AC, Nadesan P, Wei Q, et al. (2007) Beta-catenin signaling plays a disparate role in different phases of fracture repair: Implications for therapy to improve bone healing. PLoS Med 4(7): e249. http://medicine.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.pmed.0040249


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Lithium And Bone Healing." ScienceDaily. ScienceDaily, 1 August 2007. <www.sciencedaily.com/releases/2007/07/070730092341.htm>.
Public Library of Science. (2007, August 1). Lithium And Bone Healing. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2007/07/070730092341.htm
Public Library of Science. "Lithium And Bone Healing." ScienceDaily. www.sciencedaily.com/releases/2007/07/070730092341.htm (accessed August 23, 2014).

Share This




More Health & Medicine News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins