Featured Research

from universities, journals, and other organizations

Decoding Effects Of Toxins On Embryo Development Apparent

Date:
October 28, 2007
Source:
BioMed Central
Summary:
Changes in gene expression patterns in zebrafish embryos resulting from exposure to environmental toxins can identify the individual toxins at work, according to new research. The genetic response of zebrafish to each toxin can be read like a barcode, offering researchers a potential method for identifying the effects of the toxin on developing vertebrate embryos.

Zebrafish embryos were exposed to eleven common pollutants, including cadmium, mercury and arsenic. Scientists monitored changes in gene-expression profiles in order to predict the chemical that the embryo had been exposed to; the results were clear-cut for 10 out of 11 toxins.
Credit: Image courtesy of BioMed Central

Changes in gene expression patterns in zebrafish embryos resulting from exposure to environmental toxins can identify the individual toxins at work, according to research published in the online open access journal Genome Biology. The genetic response of zebrafish to each toxin can be read like a barcode, offering researchers a potential method for identifying the effects of the toxin on developing vertebrate embryos.

Zebrafish embryos were exposed to eleven common pollutants, including cadmium, mercury and arsenic, by a team led by Uwe Strähle at the Institute of Toxicology and Genetics, Karlsruhe, Germany. The team monitored changes in gene-expression profiles in order to predict the chemical that the embryo had been exposed to; the results were clear-cut for 10 out of 11 toxins.

Zebrafish have previously found a role in toxicology tests, for example in testing sewage for the presence of toxins. However, these previous tests involved looking at adult fish or embryos. The new method developed by Strähle and colleagues does distinguish individual genetic barcodes of chemicals and will help cope with the high demand from regulators and industry for reliable methods needed to evaluate the developmental toxicity of pharmaceuticals, industrial chemicals and waste products.

The research may prove valuable for initiatives such as the European Union Registration, Evaluation and Authorisation of Chemicals programme (REACH) which was set up to improve the protection of human health and the environment through the better and earlier identification of the intrinsic properties of chemical substances.

"Zebrafish embryos offer a cheap and ethically acceptable vertebrate model that will not only be useful in the toxicological assessment of the tens of thousands of compounds to be tested under the REACH programme but can also help to evaluate the developmental toxicity of novel compounds at an early stage of drug development," says Strähle.

This new work provides the basis for the development of large-scale systematic methods for identifying the potential of chemicals.

Article: Lixin Yang, Jules R Kemadjou, Christian Zinsmeister, Jessica Legradi, Matthias Bauer, Ferene Müller, Michael Pankratz, Jens Jäkel and Uwe Strähle, Transcriptional profiling reveals barcode-like toxicogenomic responses in the zebrafish embryo, Genome Biology (in press)


Story Source:

The above story is based on materials provided by BioMed Central. Note: Materials may be edited for content and length.


Cite This Page:

BioMed Central. "Decoding Effects Of Toxins On Embryo Development Apparent." ScienceDaily. ScienceDaily, 28 October 2007. <www.sciencedaily.com/releases/2007/10/071025080920.htm>.
BioMed Central. (2007, October 28). Decoding Effects Of Toxins On Embryo Development Apparent. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2007/10/071025080920.htm
BioMed Central. "Decoding Effects Of Toxins On Embryo Development Apparent." ScienceDaily. www.sciencedaily.com/releases/2007/10/071025080920.htm (accessed September 2, 2014).

Share This




More Plants & Animals News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Sharks Off the Menu and on the Tourist Trail in Palau

Sharks Off the Menu and on the Tourist Trail in Palau

AFP (Sep. 2, 2014) — Tourists in Palau clamour to dive with sharks thanks to a pioneering conservation initiative -- as the island nation plans to completely ban commercial fishing in its vast ocean territory. 01:15 Video provided by AFP
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) — Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins