Featured Research

from universities, journals, and other organizations

Domestic Cat Genome Sequenced

Date:
November 1, 2007
Source:
Cold Spring Harbor Laboratory
Summary:
The domestic cat genome has now been sequenced. The genome was of a 4-year-old Abyssinian cat named Cinnamon, who has a well-documented lineage that can be traced back several generations to Sweden. Cinnamon is one of several mammals that are currently being analyzed using "light" (two-fold) genome sequence coverage.

Of all of the cats in the world, Cinnamon was chosen to be the definitive genetic model for all cats in a project called the feline genome project. By donating a small vial of blood, Cinnamon provided scientists the wherewithal to map the feline genetic structure, eventually allowing for each gene's function to be noted and studied.
Credit: University of Missouri College of Veterinary Medicine

The DNA of a 4-year-old Abyssinian cat named Cinnamon, whose well-documented lineage can be traced back several generations to Sweden, has been sequenced. Cinnamon is one of several mammals that are currently being analyzed using "light" (two-fold) genome sequence coverage. To make sense of Cinnamon's raw sequence data, a multi-center collaboration of scientists leveraged information from previously sequenced mammalian genomes as well as previous gene-mapping studies in the cat. In doing so, they found that Cinnamon's sequences spanned about 65% of the euchromatic (gene-containing) regions of the feline genome.

The similarity between the cat genome and six recently completed mammalian genomes (human, chimpanzee, mouse, rat, dog, and cow) allowed the scientists to identify 20,285 putative genes in the cat genome. The comparison also revealed hundreds of chromosomal rearrangements that have occurred among the different lineages of mammals since they diverged from a diminutive ancestor that roamed the earth among the dinosaurs some 100 million years ago.

The genome sequence analysis is certainly expected to lead to health benefits for domestic cats, 90 million of which are owned by Americans alone, according to The Humane Society. But the domestic cat also serves as an excellent model for human disease, which is one reason why the National Human Genome Research Institute (NHGRI) initially authorized the cat genome sequencing project three years ago.

Domestic cats possess over 250 naturally occurring hereditary disorders, many of which are similar to genetic pathologies in humans. For example, Cinnamon's pedigree carries a genetic mutation that causes retinitis pigmentosa, a degenerative eye disease that can lead to blindness. In humans, retinitis pigmentosa affects 1 in 3,500 Americans. The domestic cat also serves as an excellent model for human infectious diseases, including HIV/AIDS. Feline immunodeficiency virus (FIV) is a genetic relative of human immunodeficiency virus (HIV), which causes AIDS.

Using the cat genome sequence data, the researchers identified several hundred thousand genomic variants (known as SNPs, DIPs, and STRs), which can be used to determine the genetic basis for common hereditary diseases. The scientists have already used these variants to identify the causative gene for Cinnamon's retinitis pigmentosa (they published a paper describing this study in the May/June, 2007 issue of the Journal of Heredity). These variants will also be useful for parentage testing, forensic analysis, and studies of evolution, including the reconstruction of domestication processes, fancy breed development, and ecological adaptation among the great roaring cats.

The researchers also analyzed the feline genome for interesting features such as microRNAs, Numts (pronounced "new mights"--nuclear genomic fragments that migrated to cat chromosomes from mitochondria), and a vast sea of selfish DNA-like repetitive elements. The repetitive elements included scores of genomic stretches from historic retroviruses, some with known links to cancer.

About Cinnamon

Cinnamon is a shy cat. While the other cats in Dr. Kristina Narfstrom's ophthalmology research center at the University of Missouri College of Veterinary Medicine vie for the attention of veterinary medical students and technicians, Cinnamon is more reticent, preferring to sit quietly and watch the other cats play and carouse.

Future research

Dr. Narfstrom predicts that the feline genome will rapidly shed new research light on a number of cat and human medical problems including virus-mediated diseases, respiratory problems, cancers, AIDS, immunity problems, muscular dystrophy, polycystic kidney disorder, and Dr. Narfstrom's research specialty, retinal eye diseases. Cats and humans share about 250 genetic diseases.

The Cat Genome Project is based at the National Cancer Institute (Frederick, Md.). Cinnamon lives in a cat colony maintained at the University of Missouri-Columbia. The sequencing data were generated by Agencourt Bioscience Corporation (Beverly, Mass.).

A report that appears in the scientific journal Genome Research details the first assembly, annotation, and comparative analysis of the domestic cat genome (Felis catus).


Story Source:

The above story is based on materials provided by Cold Spring Harbor Laboratory. Note: Materials may be edited for content and length.


Cite This Page:

Cold Spring Harbor Laboratory. "Domestic Cat Genome Sequenced." ScienceDaily. ScienceDaily, 1 November 2007. <www.sciencedaily.com/releases/2007/10/071031172826.htm>.
Cold Spring Harbor Laboratory. (2007, November 1). Domestic Cat Genome Sequenced. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2007/10/071031172826.htm
Cold Spring Harbor Laboratory. "Domestic Cat Genome Sequenced." ScienceDaily. www.sciencedaily.com/releases/2007/10/071031172826.htm (accessed July 28, 2014).

Share This




More Plants & Animals News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Sea Turtle Hatchlings Emerge from Nest

Raw: Sea Turtle Hatchlings Emerge from Nest

AP (July 27, 2014) A live-streaming webcam catches loggerhead sea turtle hatchlings emerging from a nest in the Florida Keys. (July 27) Video provided by AP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
The New York Times Backs Pot Legalization

The New York Times Backs Pot Legalization

Newsy (July 27, 2014) The New York Times has officially endorsed the legalization of marijuana, but why now, and to what end? Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins