Featured Research

from universities, journals, and other organizations

Fat Hormone May Contribute To Longevity

Date:
November 23, 2007
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Both humans and mice that manage to live to a ripe, old age show a clear change in their glucose metabolism, but it's unclear whether this change alone can increase lifespan. Using a mouse model of longevity scientists report that changes in metabolism can indeed increase longevity. They demonstrated that long-lived Snell dwarf mice burn less glucose and more fatty acids during periods of fasting, and as a result produce fewer free radicals.

Altered fasting metabolism may contribute to the increased longevity of Snell dwarf mice (bottom).
Credit: Terry Combs

Both humans and mice that manage to live to a ripe, old age show a clear change in their glucose metabolism, but it's unclear whether this change alone can increase lifespan.

Related Articles


Using a mouse model of longevity, Terry Combs and colleagues report that changes in metabolism can indeed increase longevity. They demonstrated that long-lived Snell dwarf mice burn less glucose and more fatty acids during periods of fasting, and as a result produce fewer free radicals.

The key to this switch may be adiponectin, a hormone produced by fat cells that helps lower glucose production and stimulates cells to use fat for energy instead. The researchers found that Snell mice had three times as much adiponectin in their blood as control mice; Snell mice also had fewer triglycerides in their cells, indicative of higher fat metabolism.

The benefit of burning fats instead of glucose for energy is that it produces fewer oxygen radicals which can damage cells and exacerbate the effects of aging. Confirming this, Combs and colleagues found far less free radical damage, measured as the frequency of a chemical modification on protein known as carbonyl groups, in Snell mice than controls.

Article: "Low utilization of circulating glucose after food withdrawal in Snell dwarf mice" by Natasha L. Brooks, Chad M. Trent, Carl F. Raetzsch, Kevin Flurkey, Gunnar Boysen, Michael T. Perfetti, Yo-Chan Jeong, Simon Klebanov, Kajal B. Patel, Valerie R. Khodush, Lawrence L. Kupper, David Carling, James A. Swenberg, David E. Harrison, and Terry P. Combs


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Fat Hormone May Contribute To Longevity." ScienceDaily. ScienceDaily, 23 November 2007. <www.sciencedaily.com/releases/2007/11/071121162443.htm>.
American Society for Biochemistry and Molecular Biology. (2007, November 23). Fat Hormone May Contribute To Longevity. ScienceDaily. Retrieved March 5, 2015 from www.sciencedaily.com/releases/2007/11/071121162443.htm
American Society for Biochemistry and Molecular Biology. "Fat Hormone May Contribute To Longevity." ScienceDaily. www.sciencedaily.com/releases/2007/11/071121162443.htm (accessed March 5, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Thursday, March 5, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ringling Bros. Eliminating Elephant Acts

Ringling Bros. Eliminating Elephant Acts

AP (Mar. 5, 2015) The Ringling Bros. and Barnum & Bailey Circus is ending its iconic elephant acts. The circus&apos; parent company, Feld Entertainment, told the AP exclusively that the acts will be phased out by 2018 over growing public concern about the animals. (March 5) Video provided by AP
Powered by NewsLook.com
Raw: Tourists Visit Rare Grey Whales in Mexico

Raw: Tourists Visit Rare Grey Whales in Mexico

AP (Mar. 4, 2015) Once nearly extinct, grey whales now migrate in their thousands to Mexico&apos;s Vizcaino reserve in Baja California, in search of warmer waters to mate and give birth. Tourists flock to the reserve to see the whales, measuring up to 49 feet long. (March 4) Video provided by AP
Powered by NewsLook.com
Australian Museum Shares Terrifying Goblin Shark With the World

Australian Museum Shares Terrifying Goblin Shark With the World

Buzz60 (Mar. 4, 2015) The Australian Museum has taken in its fourth-ever goblin shark, a rare fish with an electricity-sensing snout and &apos;alien-like&apos; jaw. Mike Janela (@mikejanela) takes a look. Video provided by Buzz60
Powered by NewsLook.com
New Hormone Could Protect Against Diabetes And Weight Gain

New Hormone Could Protect Against Diabetes And Weight Gain

Newsy (Mar. 4, 2015) A newly discovered hormone mimics the effects of exercise, protecting against diabetes and weight gain. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins