Featured Research

from universities, journals, and other organizations

Fat Hormone May Contribute To Longevity

Date:
November 23, 2007
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Both humans and mice that manage to live to a ripe, old age show a clear change in their glucose metabolism, but it's unclear whether this change alone can increase lifespan. Using a mouse model of longevity scientists report that changes in metabolism can indeed increase longevity. They demonstrated that long-lived Snell dwarf mice burn less glucose and more fatty acids during periods of fasting, and as a result produce fewer free radicals.

Altered fasting metabolism may contribute to the increased longevity of Snell dwarf mice (bottom).
Credit: Terry Combs

Both humans and mice that manage to live to a ripe, old age show a clear change in their glucose metabolism, but it's unclear whether this change alone can increase lifespan.

Using a mouse model of longevity, Terry Combs and colleagues report that changes in metabolism can indeed increase longevity. They demonstrated that long-lived Snell dwarf mice burn less glucose and more fatty acids during periods of fasting, and as a result produce fewer free radicals.

The key to this switch may be adiponectin, a hormone produced by fat cells that helps lower glucose production and stimulates cells to use fat for energy instead. The researchers found that Snell mice had three times as much adiponectin in their blood as control mice; Snell mice also had fewer triglycerides in their cells, indicative of higher fat metabolism.

The benefit of burning fats instead of glucose for energy is that it produces fewer oxygen radicals which can damage cells and exacerbate the effects of aging. Confirming this, Combs and colleagues found far less free radical damage, measured as the frequency of a chemical modification on protein known as carbonyl groups, in Snell mice than controls.

Article: "Low utilization of circulating glucose after food withdrawal in Snell dwarf mice" by Natasha L. Brooks, Chad M. Trent, Carl F. Raetzsch, Kevin Flurkey, Gunnar Boysen, Michael T. Perfetti, Yo-Chan Jeong, Simon Klebanov, Kajal B. Patel, Valerie R. Khodush, Lawrence L. Kupper, David Carling, James A. Swenberg, David E. Harrison, and Terry P. Combs


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Fat Hormone May Contribute To Longevity." ScienceDaily. ScienceDaily, 23 November 2007. <www.sciencedaily.com/releases/2007/11/071121162443.htm>.
American Society for Biochemistry and Molecular Biology. (2007, November 23). Fat Hormone May Contribute To Longevity. ScienceDaily. Retrieved July 27, 2014 from www.sciencedaily.com/releases/2007/11/071121162443.htm
American Society for Biochemistry and Molecular Biology. "Fat Hormone May Contribute To Longevity." ScienceDaily. www.sciencedaily.com/releases/2007/11/071121162443.htm (accessed July 27, 2014).

Share This




More Plants & Animals News

Sunday, July 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

How to Make Single Serving Smoothies: Howdini Hacks

How to Make Single Serving Smoothies: Howdini Hacks

Howdini (July 24, 2014) Smoothies are a great way to get in lots of healthy ingredients, plus they taste great! Howdini has a trick for making the perfect single-size smoothie that will save you time on cleanup too! All you need is a blender and a mason jar. Video provided by Howdini
Powered by NewsLook.com
Boy Attacked by Shark in Florida

Boy Attacked by Shark in Florida

Reuters - US Online Video (July 24, 2014) An 8-year-old boy is bitten in the leg by a shark while vacationing at a Florida beach. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Goma Cheese Brings Whiff of New Hope to DRC

Goma Cheese Brings Whiff of New Hope to DRC

Reuters - Business Video Online (July 24, 2014) The eastern region of the Democratic Republic of Congo, mainly known for conflict and instability, is an unlikely place for the production of fine cheese. But a farm in the village of Masisi, in North Kivu is slowly transforming perceptions of the area. Known simply as Goma cheese, the Congolese version of Dutch gouda has gained popularity through out the region. Ciara Sutton reports. Video provided by Reuters
Powered by NewsLook.com
Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Tyrannosaur Pack-Hunting Theory Aided By New Footprints

Newsy (July 24, 2014) A new study claims a set of prehistoric T-Rex footprints supports the theory that the giant predators hunted in packs instead of alone. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins