Featured Research

from universities, journals, and other organizations

Levels Of Prion Protein In Brain May Not Be Reliable Marker For Disease

Date:
December 1, 2007
Source:
American Society for Biochemistry and Molecular Biology
Summary:
Rapid diagnostic testing used to check for the presence of prion diseases such as "mad cow disease" might fail to identify some highly infectious samples, researchers have found.

Rapid diagnostic testing used to check for the presence of prion diseases such as "mad cow disease" might fail to identify some highly infectious samples, researchers have found.

Currently, scanning beef or other meat products for possible prion infection involves sampling brain tissue from the animal for abnormally folded prion protein, also called PrP; this form of PrP, which is sticky and hard to degrade, is believed to be the infectious agent behind prion diseases.

Rona Barron and colleagues tested whether abnormal PrP and infectivity was an absolute association. They injected mice with two different strains of prion-infected tissue and quantified the degree of infection in these mice.

Next, they examined the amount of abnormally folded PrP in brains of the sick mice and found that it did not correlate in any way with how infectious the disease strain was; in fact, some highly infectious tissue samples had nearly undetectable levels of abnormal PrP.

These data suggest that not all abnormal PrP found in diseased tissues is infectious, and may instead be a pathologic by-product of disease. Some other agent, or a specific conformation of abnormally folded PrP, may therefore be responsible for prion disease, and current assays relying solely on abnormal PrP detection could therefore underestimate the frequency of infection.

Barron and colleagues note that it's vital to find additional disease markers to help ensure no future prion outbreaks occur.

Appearing online Nov. 30, 2007 in the Journal of Biological Chemistry, vol 282, #49


Story Source:

The above story is based on materials provided by American Society for Biochemistry and Molecular Biology. Note: Materials may be edited for content and length.


Cite This Page:

American Society for Biochemistry and Molecular Biology. "Levels Of Prion Protein In Brain May Not Be Reliable Marker For Disease." ScienceDaily. ScienceDaily, 1 December 2007. <www.sciencedaily.com/releases/2007/11/071130144506.htm>.
American Society for Biochemistry and Molecular Biology. (2007, December 1). Levels Of Prion Protein In Brain May Not Be Reliable Marker For Disease. ScienceDaily. Retrieved August 23, 2014 from www.sciencedaily.com/releases/2007/11/071130144506.htm
American Society for Biochemistry and Molecular Biology. "Levels Of Prion Protein In Brain May Not Be Reliable Marker For Disease." ScienceDaily. www.sciencedaily.com/releases/2007/11/071130144506.htm (accessed August 23, 2014).

Share This




More Plants & Animals News

Saturday, August 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Endangered Red Wolves Face Uncertain Future

Endangered Red Wolves Face Uncertain Future

AP (Aug. 22, 2014) A federal judge temporarily banned coyote hunting to save endangered red wolves, but local hunters say that the wolf preservation program does more harm than good. Meanwhile federal officials are reviewing its wolf program in North Carolina. (Aug. 22) Video provided by AP
Powered by NewsLook.com
Farm Resurgence Grows With Younger Crowd

Farm Resurgence Grows With Younger Crowd

AP (Aug. 22, 2014) New England farms are seeing a surge in younger farm hands as the 'buy local' food movement grows across the country. (Aug. 22) Video provided by AP
Powered by NewsLook.com
Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Terrifying City-Dwelling Spiders Are Bigger And More Fertile

Newsy (Aug. 21, 2014) According to a new study, spiders that live in cities are bigger, fatter and multiply faster. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins