Featured Research

from universities, journals, and other organizations

New Cause Identified For Necrotic Enteritis In Chicken

Date:
February 7, 2008
Source:
Public Library of Science
Summary:
Researchers have demonstrated for the first time that alpha-toxin protein, long thought to be required for necrotic enteritis to develop, is not the main cause of the chicken disease. The study provides insight into one of the world's most common and financially crippling poultry diseases.

Researchers from Monash University and CSIRO Livestock Industries have demonstrated for the first time that alpha-toxin protein, long thought to be required for necrotic enteritis to develop, is not the main cause of the chicken disease. The study provides insight into one of the world's most common and financially crippling poultry diseases.

Related Articles


"It's caused by Clostridium perfringens, a bacterium found in soil, litter, dust and in small quantities in the intestines of healthy chickens," said co-author Anthony Keyburn, "The bacterium only causes disease when it proliferates to high numbers, producing extracellular toxins that attack the bird's intestines, causing lesions." .

Poultry producers use antibiotics to treat and prevent the disease, which, when triggered, can cause mortality rates of up to 50 per cent. Necrotic enteritis costs the world's poultry industries an estimated US$2 billion every year.

The disease was first described in 1961 and alpha-toxin was implicated as the major causative factor, although definitive proof has never been reported. As a result, for the last 30 years all vaccine development work has been based on the assumption that alpha-toxin was the key.

Mr Keyburn said the research team began to question the involvement of alpha-toxin when a survey showed that local disease-causing bacterial strains produced low levels of this toxin.

"We tested the importance of alpha-toxin by genetically altering the bacterium so it no longer produced any of the protein," he said. "Despite the toxin's absence, our bacterial isolates still caused disease in chickens. This demonstrates that the development of necrotic enteritis in chickens is not dependent on C. perfringens producing a functional alpha-toxin."

This finding led the team to expand their search for the real cause of necrotic enteritis, finding a novel toxin -- NetB -- that is involved in the disease-causing potential of a high proportion of virulent C. perfringens strains.

The authors are now investigating NetB and other proteins produced by C. perfringens, with the aim of developing effective vaccines against the disease.

"Around the world, poultry producers are waiting for vaccines against necrotic enteritis," said co-author Rob Moore. "Thanks to Anthony's discoveries, scientists should now be able to develop the vaccines within a couple of years."

Journal reference: Keyburn AL, Boyce JD, Vaz P, Bannam TL, Ford ME, et al. (2008) NetB, a new toxin that is associated with avian necrotic enteritis caused by Clostridium perfringens. PLoS Pathog 4(2): e26. doi:10.1371/journal.ppat.0040026 http://pathogens.plosjournals.org/perlserv/?request=get-document&doi=10.1371/journal.ppat.0040026


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "New Cause Identified For Necrotic Enteritis In Chicken." ScienceDaily. ScienceDaily, 7 February 2008. <www.sciencedaily.com/releases/2008/02/080207203921.htm>.
Public Library of Science. (2008, February 7). New Cause Identified For Necrotic Enteritis In Chicken. ScienceDaily. Retrieved October 31, 2014 from www.sciencedaily.com/releases/2008/02/080207203921.htm
Public Library of Science. "New Cause Identified For Necrotic Enteritis In Chicken." ScienceDaily. www.sciencedaily.com/releases/2008/02/080207203921.htm (accessed October 31, 2014).

Share This



More Plants & Animals News

Friday, October 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Watch Baby Goose Survive A 400-Foot Cliff Dive

Watch Baby Goose Survive A 400-Foot Cliff Dive

Buzz60 (Oct. 31, 2014) For its nature series Life Story, the BBC profiled the barnacle goose, whose chicks must make a daredevil 400-foot cliff dive from their nests to find food. Jen Markham has the astonishing video. Video provided by Buzz60
Powered by NewsLook.com
World's Salamanders At Risk From Flesh-Eating Fungus

World's Salamanders At Risk From Flesh-Eating Fungus

Newsy (Oct. 31, 2014) The import of salamanders around the globe is thought to be contributing to the spread of a deadly fungus. Video provided by Newsy
Powered by NewsLook.com
Alcoholic Drinks In The E.U. Could Get Calorie Labels

Alcoholic Drinks In The E.U. Could Get Calorie Labels

Newsy (Oct. 31, 2014) A health group in the United Kingdom has called for mandatory calorie labels on alcoholic beverages in the European Union. Video provided by Newsy
Powered by NewsLook.com
Malaria Threat in Liberia as Fight Against Ebola Rages

Malaria Threat in Liberia as Fight Against Ebola Rages

AFP (Oct. 31, 2014) Focus on treating the Ebola epidemic in Liberia means that treatment for malaria, itself a killer, is hard to come by. MSF are now undertaking the mass distribution of antimalarials in Monrovia. Duration: 00:38 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins