Featured Research

from universities, journals, and other organizations

Gene-environment Interaction In Yeast Gene Expression

Date:
April 15, 2008
Source:
Public Library of Science
Summary:
Researchers have shown that gene-environment interaction is a common phenomenon in the regulation of gene expression. In a new study, they describe how different classes of genetic variants affect the nature of the interactions, and provide detailed molecular examples of interactions.

The nature vs. nurture debate is familiar to most people, and modern conclusions usually predict a balance between the two. A new paper published this week in the open-access journal PLoS Biology shows that there is a similar balance between the genes we inherit -- nature -- and the environment -- nurture -- in determining thousands of traits in yeast.

As we approach the age of personal genomics, in which each of us knows something about the genetic variations we carry, it is important to understand how genes and the environment interact in order to draw medically sound conclusions from the information available -- e.g. whether exercise can reduce risks that are increased because of a genetic predisposition towards a certain illness.

The phenomenon of gene/environment interaction has been documented before, that the environment affects the ways it genes are expressed so that genes that are on in one condition may be downregulated or switched off in other environments. What the new research, by Leonid Kruglyak and Erin Smith, of Princeton University, adds is the ability to study thousands of gene expression patterns simultaneously, to understand the general properties of these previously poorly understood interactions.

In this research, the individuals are yeast -- one from the lab and one from the vineyard, which differed genetically and the environment varied between two energy sources: glucose and ethanol. The experiment, then, is to measure how the genetic and the environmental differences interact to alter the gene expression of the yeast cells.

The expression of many genes is under the control of other genes. This paper shows that the environment often has a bigger effect on these regulated genes than on ones that are switched on and off by other, more direct mechanisms. Intriguingly, sometimes a control gene that positively affects another gene in one environment may have the opposite effect in another environment.

Citation: Smith EN, Kruglyak L (2008) Geneβ€"environment interaction in yeast gene expression. PLoS Biol 6(4): e83. doi:10.1371/journal.pbio.0060083


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Gene-environment Interaction In Yeast Gene Expression." ScienceDaily. ScienceDaily, 15 April 2008. <www.sciencedaily.com/releases/2008/04/080414082541.htm>.
Public Library of Science. (2008, April 15). Gene-environment Interaction In Yeast Gene Expression. ScienceDaily. Retrieved September 16, 2014 from www.sciencedaily.com/releases/2008/04/080414082541.htm
Public Library of Science. "Gene-environment Interaction In Yeast Gene Expression." ScienceDaily. www.sciencedaily.com/releases/2008/04/080414082541.htm (accessed September 16, 2014).

Share This



More Plants & Animals News

Tuesday, September 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Tobacco Farmers Thrive Amid Challenges

Some Tobacco Farmers Thrive Amid Challenges

AP (Sep. 16, 2014) — The South's tobacco country is surviving, and even thriving in some cases, as demand overseas keeps growers in the fields of one of America's oldest cash crops. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

AFP (Sep. 16, 2014) — Scientists say a female colossal squid weighing an estimated 350 kilograms (770 lbs) and thought to be only the second intact specimen ever found was carrying eggs when discovered in the Antarctic. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Raw: Scientists Examine Colossal Squid

Raw: Scientists Examine Colossal Squid

AP (Sep. 16, 2014) — Squid experts in New Zealand thawed and examined an unusual catch on Tuesday: a colossal squid. It was captured in Antarctica's remote Ross Sea in December last year and has been frozen for eight months. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

Ivorians Abandon Monkey Pets in Fear Over Ebola Virus

AFP (Sep. 16, 2014) — Since the arrival of Ebola in Ivory Coast, Ivorians have been abandoning their pets, particularly monkeys, in the fear that they may transmit the virus. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

      Technology News



      Save/Print:
      Share:  

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile iPhone Android Web
      Follow Facebook Twitter Google+
      Subscribe RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins