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Gene-environment Interaction In Yeast Gene Expression

Date:
April 15, 2008
Source:
Public Library of Science
Summary:
Researchers have shown that gene-environment interaction is a common phenomenon in the regulation of gene expression. In a new study, they describe how different classes of genetic variants affect the nature of the interactions, and provide detailed molecular examples of interactions.

The nature vs. nurture debate is familiar to most people, and modern conclusions usually predict a balance between the two. A new paper published this week in the open-access journal PLoS Biology shows that there is a similar balance between the genes we inherit -- nature -- and the environment -- nurture -- in determining thousands of traits in yeast.

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As we approach the age of personal genomics, in which each of us knows something about the genetic variations we carry, it is important to understand how genes and the environment interact in order to draw medically sound conclusions from the information available -- e.g. whether exercise can reduce risks that are increased because of a genetic predisposition towards a certain illness.

The phenomenon of gene/environment interaction has been documented before, that the environment affects the ways it genes are expressed so that genes that are on in one condition may be downregulated or switched off in other environments. What the new research, by Leonid Kruglyak and Erin Smith, of Princeton University, adds is the ability to study thousands of gene expression patterns simultaneously, to understand the general properties of these previously poorly understood interactions.

In this research, the individuals are yeast -- one from the lab and one from the vineyard, which differed genetically and the environment varied between two energy sources: glucose and ethanol. The experiment, then, is to measure how the genetic and the environmental differences interact to alter the gene expression of the yeast cells.

The expression of many genes is under the control of other genes. This paper shows that the environment often has a bigger effect on these regulated genes than on ones that are switched on and off by other, more direct mechanisms. Intriguingly, sometimes a control gene that positively affects another gene in one environment may have the opposite effect in another environment.

Citation: Smith EN, Kruglyak L (2008) Geneβ€"environment interaction in yeast gene expression. PLoS Biol 6(4): e83. doi:10.1371/journal.pbio.0060083


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The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


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Public Library of Science. "Gene-environment Interaction In Yeast Gene Expression." ScienceDaily. ScienceDaily, 15 April 2008. <www.sciencedaily.com/releases/2008/04/080414082541.htm>.
Public Library of Science. (2008, April 15). Gene-environment Interaction In Yeast Gene Expression. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2008/04/080414082541.htm
Public Library of Science. "Gene-environment Interaction In Yeast Gene Expression." ScienceDaily. www.sciencedaily.com/releases/2008/04/080414082541.htm (accessed March 31, 2015).

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