Featured Research

from universities, journals, and other organizations

Gene-environment Interaction In Yeast Gene Expression

Date:
April 15, 2008
Source:
Public Library of Science
Summary:
Researchers have shown that gene-environment interaction is a common phenomenon in the regulation of gene expression. In a new study, they describe how different classes of genetic variants affect the nature of the interactions, and provide detailed molecular examples of interactions.

The nature vs. nurture debate is familiar to most people, and modern conclusions usually predict a balance between the two. A new paper published this week in the open-access journal PLoS Biology shows that there is a similar balance between the genes we inherit -- nature -- and the environment -- nurture -- in determining thousands of traits in yeast.

As we approach the age of personal genomics, in which each of us knows something about the genetic variations we carry, it is important to understand how genes and the environment interact in order to draw medically sound conclusions from the information available -- e.g. whether exercise can reduce risks that are increased because of a genetic predisposition towards a certain illness.

The phenomenon of gene/environment interaction has been documented before, that the environment affects the ways it genes are expressed so that genes that are on in one condition may be downregulated or switched off in other environments. What the new research, by Leonid Kruglyak and Erin Smith, of Princeton University, adds is the ability to study thousands of gene expression patterns simultaneously, to understand the general properties of these previously poorly understood interactions.

In this research, the individuals are yeast -- one from the lab and one from the vineyard, which differed genetically and the environment varied between two energy sources: glucose and ethanol. The experiment, then, is to measure how the genetic and the environmental differences interact to alter the gene expression of the yeast cells.

The expression of many genes is under the control of other genes. This paper shows that the environment often has a bigger effect on these regulated genes than on ones that are switched on and off by other, more direct mechanisms. Intriguingly, sometimes a control gene that positively affects another gene in one environment may have the opposite effect in another environment.

Citation: Smith EN, Kruglyak L (2008) Geneβ€"environment interaction in yeast gene expression. PLoS Biol 6(4): e83. doi:10.1371/journal.pbio.0060083


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Cite This Page:

Public Library of Science. "Gene-environment Interaction In Yeast Gene Expression." ScienceDaily. ScienceDaily, 15 April 2008. <www.sciencedaily.com/releases/2008/04/080414082541.htm>.
Public Library of Science. (2008, April 15). Gene-environment Interaction In Yeast Gene Expression. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2008/04/080414082541.htm
Public Library of Science. "Gene-environment Interaction In Yeast Gene Expression." ScienceDaily. www.sciencedaily.com/releases/2008/04/080414082541.htm (accessed July 28, 2014).

Share This




More Plants & Animals News

Monday, July 28, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Sea Turtle Hatchlings Emerge from Nest

Raw: Sea Turtle Hatchlings Emerge from Nest

AP (July 27, 2014) — A live-streaming webcam catches loggerhead sea turtle hatchlings emerging from a nest in the Florida Keys. (July 27) Video provided by AP
Powered by NewsLook.com
Trees Could Save More Than 850 Lives Each Year

Trees Could Save More Than 850 Lives Each Year

Newsy (July 27, 2014) — A national study conducted by the USDA Forest Service found that trees collectively save more than 850 lives on an annual basis. Video provided by Newsy
Powered by NewsLook.com
What's To Blame For Worst Ebola Outbreak In History?

What's To Blame For Worst Ebola Outbreak In History?

Newsy (July 27, 2014) — A U.S. doctor has tested positive for the deadly Ebola virus, as the worst-ever outbreak continues to grow. Video provided by Newsy
Powered by NewsLook.com
The New York Times Backs Pot Legalization

The New York Times Backs Pot Legalization

Newsy (July 27, 2014) — The New York Times has officially endorsed the legalization of marijuana, but why now, and to what end? Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins