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Novel Therapeutic Strategy For Colon Cancer Treatment

Date:
June 10, 2008
Source:
Agency for Science, Technology and Research (A*STAR), Singapore
Summary:
Genetic and epigenetic defects in signaling of protein called Wnt/²-catenin, which is often found to be abnormally activated in human malignance, play important roles in colorectal cancer development. Scientists identified a gene, called DACT3, whose function is to inhibit Wnt/²-catenin, is often lost (or transcriptionally silenced) in colorectal cancer.

A team of scientists at the Genome Institute of Singapore (GIS), a research institute of the Asian city-state's Agency for Science, Technology and Research (A*STAR), and the University of California at San Francisco have developed a pharmacological approach to kill colon cancer cells.

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Genetic and epigenetic defects in the signaling of a protein called Wnt/²-catenin, which is often found to be abnormally activated in human malignance, play important roles in colorectal cancer development. The team of scientists identified a gene, called DACT3, whose function is to inhibit Wnt/²-catenin, is often lost (or transcriptionally silenced) in colorectal cancer.

Apart from the findings on DACT3, they have also developed a pharmacological approach to restore the expression of DACT3, which results in the effective inhibition of Wnt/²-catenin massive death of colon cancer cells.

GIS Group Leader, Yu Qiang, Ph.D., said, "This work identifies a significant new regulator of the Wnt/²-catenin avenue for future colorectal cancer research."

Edison Liu, M.D., Executive Director of GIS, added, "This is indeed a very significant discovery. It suggests a novel therapy for colorectal cancer, an important step towards clinical treatment for the disease, which is one of the leading causes of death from tumours."

The team is now working with other A*STAR research institutes and industry partners for the development of potential drug candidates based on this technology.


Story Source:

The above story is based on materials provided by Agency for Science, Technology and Research (A*STAR), Singapore. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xia Jiang et al. DACT3 is an epigenetic regulator of Wnt/%u03B2-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell, June 9, 2008

Cite This Page:

Agency for Science, Technology and Research (A*STAR), Singapore. "Novel Therapeutic Strategy For Colon Cancer Treatment." ScienceDaily. ScienceDaily, 10 June 2008. <www.sciencedaily.com/releases/2008/06/080610092723.htm>.
Agency for Science, Technology and Research (A*STAR), Singapore. (2008, June 10). Novel Therapeutic Strategy For Colon Cancer Treatment. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2008/06/080610092723.htm
Agency for Science, Technology and Research (A*STAR), Singapore. "Novel Therapeutic Strategy For Colon Cancer Treatment." ScienceDaily. www.sciencedaily.com/releases/2008/06/080610092723.htm (accessed March 31, 2015).

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