Featured Research

from universities, journals, and other organizations

Novel Therapeutic Strategy For Colon Cancer Treatment

Date:
June 10, 2008
Source:
Agency for Science, Technology and Research (A*STAR), Singapore
Summary:
Genetic and epigenetic defects in signaling of protein called Wnt/-catenin, which is often found to be abnormally activated in human malignance, play important roles in colorectal cancer development. Scientists identified a gene, called DACT3, whose function is to inhibit Wnt/-catenin, is often lost (or transcriptionally silenced) in colorectal cancer.

A team of scientists at the Genome Institute of Singapore (GIS), a research institute of the Asian city-state's Agency for Science, Technology and Research (A*STAR), and the University of California at San Francisco have developed a pharmacological approach to kill colon cancer cells.

Genetic and epigenetic defects in the signaling of a protein called Wnt/-catenin, which is often found to be abnormally activated in human malignance, play important roles in colorectal cancer development. The team of scientists identified a gene, called DACT3, whose function is to inhibit Wnt/-catenin, is often lost (or transcriptionally silenced) in colorectal cancer.

Apart from the findings on DACT3, they have also developed a pharmacological approach to restore the expression of DACT3, which results in the effective inhibition of Wnt/-catenin massive death of colon cancer cells.

GIS Group Leader, Yu Qiang, Ph.D., said, "This work identifies a significant new regulator of the Wnt/-catenin avenue for future colorectal cancer research."

Edison Liu, M.D., Executive Director of GIS, added, "This is indeed a very significant discovery. It suggests a novel therapy for colorectal cancer, an important step towards clinical treatment for the disease, which is one of the leading causes of death from tumours."

The team is now working with other A*STAR research institutes and industry partners for the development of potential drug candidates based on this technology.


Story Source:

The above story is based on materials provided by Agency for Science, Technology and Research (A*STAR), Singapore. Note: Materials may be edited for content and length.


Journal Reference:

  1. Xia Jiang et al. DACT3 is an epigenetic regulator of Wnt/%u03B2-catenin signaling in colorectal cancer and is a therapeutic target of histone modifications. Cancer Cell, June 9, 2008

Cite This Page:

Agency for Science, Technology and Research (A*STAR), Singapore. "Novel Therapeutic Strategy For Colon Cancer Treatment." ScienceDaily. ScienceDaily, 10 June 2008. <www.sciencedaily.com/releases/2008/06/080610092723.htm>.
Agency for Science, Technology and Research (A*STAR), Singapore. (2008, June 10). Novel Therapeutic Strategy For Colon Cancer Treatment. ScienceDaily. Retrieved July 30, 2014 from www.sciencedaily.com/releases/2008/06/080610092723.htm
Agency for Science, Technology and Research (A*STAR), Singapore. "Novel Therapeutic Strategy For Colon Cancer Treatment." ScienceDaily. www.sciencedaily.com/releases/2008/06/080610092723.htm (accessed July 30, 2014).

Share This




More Health & Medicine News

Wednesday, July 30, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Concern Grows Over Worsening Ebola Crisis

Concern Grows Over Worsening Ebola Crisis

AFP (July 30, 2014) Pan-African airline ASKY has suspended all flights to and from the capitals of Liberia and Sierra Leone amid the worsening Ebola health crisis, which has so far caused 672 deaths in Guinea, Liberia and Sierra Leone. Duration: 00:43 Video provided by AFP
Powered by NewsLook.com
At Least 20 Chikungunya Cases in New Jersey

At Least 20 Chikungunya Cases in New Jersey

AP (July 30, 2014) At least 20 New Jersey residents have tested positive for chikungunya, a mosquito-borne virus that has spread through the Caribbean. (July 30) Video provided by AP
Powered by NewsLook.com
Generics Eat Into Pfizer's Sales

Generics Eat Into Pfizer's Sales

Reuters - Business Video Online (July 29, 2014) Pfizer, the world's largest drug maker, cut full-year revenue forecasts because generics could cut into sales of its anti-arthritis drug, Celebrex. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

    Environment News

    Technology News



      Save/Print:
      Share:

      Free Subscriptions


      Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

      Get Social & Mobile


      Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

      Have Feedback?


      Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
      Mobile: iPhone Android Web
      Follow: Facebook Twitter Google+
      Subscribe: RSS Feeds Email Newsletters
      Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins