Featured Research

from universities, journals, and other organizations

Starvation Hormone Makes For Small Mice, Study Finds

Date:
June 28, 2008
Source:
Cell Press
Summary:
Chronically high levels of a recently discovered starvation hormone markedly stunt the growth of mice, reveals a new study. The liver-produced hormone known as FGF21 does so by causing the mice to become resistant to growth hormone.

Chronically high levels of a recently discovered starvation hormone markedly stunt the growth of mice, reveals a new study in the July issue of Cell Metabolism. The liver-produced hormone known as FGF21 does so by causing the mice to become resistant to growth hormone.

"It was an unexpected finding," said David Mangelsdorf of University of Texas Southwestern Medical Center. "In starvation, [it was known that] growth hormone goes down. This might explain much of the mechanism responsible."

The researchers showed in another Cell Metabolism report last year that FGF21 shifts the metabolism of mice to a fat-burning mode and induces a state of energy-conserving torpor. FGF21 has since been shown to act as an insulin sensitizer, as well.

The new findings uncover an even broader physiological role for the hormone in promoting energy conservation when animals go without food, said Mangelsdorf and study coauthor Steven Kliewer, also of the University of Texas Southwestern Medical Center.

They report that mice with higher-than-normal levels of FGF21 are normally sized at birth, but they gain less weight and their bones grow less. That's despite the fact that the animals eat more relative to their body weight than control mice do.

Further study showed that FGF21 reduced concentrations of a growth hormone-mediating transcription factor (a gene that controls the activity of other genes), leading to a decline in the expression of its target genes, including insulin-like growth factor 1 (IGF-1).

The earlier discovery of FGF21's effects on fat metabolism and insulin response have led to considerable interest in its potential use as a type 2 diabetes drug, Mangelsdorf said. Therefore, it will be important to understand what else the hormone might do.

On the plus side, FGF21's growth hormone actions, along with its insulin effects, support the notion that it might extend life span, a hypothesis Mangelsdorf and Kliewer's team intends to explore. On the other hand, chronically blocking growth hormone could have other ill effects.

The new results might also explain the action of fibrate drugs now in use for treating patients with metabolic syndrome, Mangelsdorf said. Those drugs target a receptor known as PPARa, which is necessary for rise in FGF21 that occurs in fasted mice.

Notably, in clinical studies, the PPARa-agonist bezafibrate significantly lowers IGF-1 levels in patients," the researchers said. "This finding together with data showing that FGF21 expression is induced by PPARa agonists in primary human [liver cells] suggest that the PPARa/FGF21 pathway may be operative and affect IGF-1 signaling in humans."

The researchers include Takeshi Inagaki, University of Texas Southwestern Medical Center, Dallas, TX; Vicky Y. Lin, University of Texas Southwestern Medical Center, Dallas, TX; Regina Goetz, New York University School of Medicine, New York, NY ; Moosa Mohammadi, New York University School of Medicine, New York, NY; David J. Mangelsdorf, University of Texas Southwestern Medical Center, Dallas, TX; and Steven A. Kliewer, University of Texas Southwestern Medical Center, Dallas, TX.


Story Source:

The above story is based on materials provided by Cell Press. Note: Materials may be edited for content and length.


Cite This Page:

Cell Press. "Starvation Hormone Makes For Small Mice, Study Finds." ScienceDaily. ScienceDaily, 28 June 2008. <www.sciencedaily.com/releases/2008/06/080626125827.htm>.
Cell Press. (2008, June 28). Starvation Hormone Makes For Small Mice, Study Finds. ScienceDaily. Retrieved August 22, 2014 from www.sciencedaily.com/releases/2008/06/080626125827.htm
Cell Press. "Starvation Hormone Makes For Small Mice, Study Finds." ScienceDaily. www.sciencedaily.com/releases/2008/06/080626125827.htm (accessed August 22, 2014).

Share This




More Health & Medicine News

Friday, August 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Drug Used To Treat 'Ebola's Cousin' Shows Promise

Newsy (Aug. 21, 2014) An experimental drug used to treat Marburg virus in rhesus monkeys could give new insight into a similar treatment for Ebola. Video provided by Newsy
Powered by NewsLook.com
Two US Ebola Patients Leave Hospital Free of the Disease

Two US Ebola Patients Leave Hospital Free of the Disease

AFP (Aug. 21, 2014) Two American missionaries who were sickened with Ebola while working in Liberia and were treated with an experimental drug are doing better and have left the hospital, doctors say on August 21, 2014. Duration: 01:05 Video provided by AFP
Powered by NewsLook.com
Cadavers, a Teen, and a Medical School Dream

Cadavers, a Teen, and a Medical School Dream

AP (Aug. 21, 2014) Contains graphic content. He's only 17. But Johntrell Bowles has wanted to be a doctor from a young age, despite the odds against him. He was recently the youngest participant in a cadaver program at the Indiana University NW medical school. (Aug. 21) Video provided by AP
Powered by NewsLook.com
American Ebola Patients Released: What Cured Them?

American Ebola Patients Released: What Cured Them?

Newsy (Aug. 21, 2014) It's unclear whether the American Ebola patients' recoveries can be attributed to an experimental drug or early detection and good medical care. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins