Featured Research

from universities, journals, and other organizations

Novel Method Quickens Discovery Of Gene Function

Date:
August 8, 2008
Source:
Texas A&M University
Summary:
Think researchers know all there is to know about Escherichia coli, commonly known as E. coli? Think again. "E. coli has more than four thousand genes, and the functions of one-fourth of these remain unknown," says a biology professor whose laboratory specializes in carrying out research using the bacterium.

Think researchers know all there is to know about Escherichia coli, commonly known as E. coli? Think again. "E. coli has more than four thousand genes, and the functions of one-fourth of these remain unknown," says Dr. Deborah Siegele, a biology professor at Texas A&M University whose laboratory specializes in carrying out research using the bacterium.

Related Articles


Harmless E. coli strains are normally found in the intestines of many animals, including humans, but some strains can cause diseases.

Siegele and her co-workers at the University of California San Francisco, Nara Institute of Science Technology and Purdue University have devised a novel method that allows rapid and large-scale studies of the E. coli genes. The researchers believe their new method, described in the current online issue of Nature Methods, will allow them to gain a better understanding of the E. coli gene functions.

The principle behind this new method is genetic interaction. Interaction between genes produces observable effects, and this allows researchers to identify the gene functions. The research team has called their new method GIANT-Coli, short for genetic interaction analysis technology for E. coli.

The team believes that its method has great potential to quicken the progress of discovering new gene functions. The use of GIANT-Coli has already allowed researchers to identify some previously unknown genetic interactions in E. coli.

To study genetic interaction, researchers need to use what they call double-mutant strains. GIANT-Coli allows large-scale generation of these double-mutant strains (high-throughput generation). And this is the first time that a high-throughput generation method for double mutants of E. coli has been developed.

Why is it so important to know the E. coli better? "Much of what we know about other bacteria, including the more dangerous ones like Vibrio cholerae, comes from our knowledge of E. coli," says Siegele. "The E. coli is a model organism."

Siegele says that GIANT-Coli can be developed to study genetic interactions in other bacteria, and because some proteins are conserved from bacteria to humans, perhaps some of the results can even be extrapolated to gene function in humans. Moreover, Siegele points out that the method has obvious application in medicine because understanding gene functions in harmful bacteria will help in developing better treatment approaches.


Story Source:

The above story is based on materials provided by Texas A&M University. Note: Materials may be edited for content and length.


Cite This Page:

Texas A&M University. "Novel Method Quickens Discovery Of Gene Function." ScienceDaily. ScienceDaily, 8 August 2008. <www.sciencedaily.com/releases/2008/08/080806184911.htm>.
Texas A&M University. (2008, August 8). Novel Method Quickens Discovery Of Gene Function. ScienceDaily. Retrieved April 21, 2015 from www.sciencedaily.com/releases/2008/08/080806184911.htm
Texas A&M University. "Novel Method Quickens Discovery Of Gene Function." ScienceDaily. www.sciencedaily.com/releases/2008/08/080806184911.htm (accessed April 21, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, April 21, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deepwater And Dolphins: The Oil Spill's Impact 5 Years On

Deepwater And Dolphins: The Oil Spill's Impact 5 Years On

Newsy (Apr. 20, 2015) Five years on, the possible environmental impact of the Deepwater Horizon spill includes a sustained die-off of bottlenose dolphins, among others. Video provided by Newsy
Powered by NewsLook.com
Five Years Later, the BP Oil Spill Is Still Taking Its Toll

Five Years Later, the BP Oil Spill Is Still Taking Its Toll

AFP (Apr. 20, 2015) On April 20, 2010, an explosion and fire on the Deepwater Horizon rig in the Gulf of Mexico started the biggest oil spill in US history. BP recently reported the Gulf is recovering well, but scientists paint a different picture. Duration: 02:36 Video provided by AFP
Powered by NewsLook.com
Thai Customs Seize African Elephant Tusks Worth $6 Mn

Thai Customs Seize African Elephant Tusks Worth $6 Mn

AFP (Apr. 20, 2015) Thai customs seize four tonnes of African elephant ivory worth $6 million at a Bangkok port in a container labelled as beans. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Reuters - US Online Video (Apr. 17, 2015) A truck carrying honey bees overturns near Lynnwood, Washington, spreading boxes of live bees across the highway. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins