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Stem Cell Transplantation Benefits Mice With Childhood Motor Neuron Disease

Date:
September 8, 2008
Source:
Journal of Clinical Investigation
Summary:
The motor neuron disease spinal muscular atrophy (SMA) is the second most common genetic disorder leading to death in childhood. There is currently no cure for SMA, but some clinicians and researchers consider stem cell transplantation as a potential therapeutic strategy. And now, work using a mouse model of SMA suggests that spinal cord neural stem cells might be a possible treatment for individuals with SMA.

The motor neuron disease spinal muscular atrophy (SMA) is the second most common genetic disorder leading to death in childhood. There is currently no cure for SMA, but some clinicians and researchers consider stem cell transplantation as a potential therapeutic strategy.

And now, Giacomo Comi and colleagues, at the University of Milan, Italy, have generated data using a mouse model of SMA to suggest that spinal cord neural stem cells (NSCs) might be a possible treatment for individuals with SMA.

In the study, NSCs from mice in which a green marker protein was expressed only in nerve cells known as motor neurons (the cells that are defective in SMA) were transplanted into the fluid bathing the spinal cord of mice with an SMA-like disease.

The transplanted cells developed into a small number of motor neurons and the treated mice showed improved muscular function and increased lifespan, when compared with untreated mice.

Further analysis indicated that the major effect of NSC transplantation was that the transplanted cells improved the survival and function of the motor neurons already in the mice, making them more like normal motor neurons (at the gene expression level).

The authors therefore suggest that in the future, NSCs might be used in the development of therapeutic protocols for the treatment of SMA and other motor neuron diseases.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. Neural stem cell transplantation can ameliorate the phenotype of a mouse model of spinal muscular atrophy. Journal of Clinical Investigation, September 3, 2008

Cite This Page:

Journal of Clinical Investigation. "Stem Cell Transplantation Benefits Mice With Childhood Motor Neuron Disease." ScienceDaily. ScienceDaily, 8 September 2008. <www.sciencedaily.com/releases/2008/09/080902221737.htm>.
Journal of Clinical Investigation. (2008, September 8). Stem Cell Transplantation Benefits Mice With Childhood Motor Neuron Disease. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2008/09/080902221737.htm
Journal of Clinical Investigation. "Stem Cell Transplantation Benefits Mice With Childhood Motor Neuron Disease." ScienceDaily. www.sciencedaily.com/releases/2008/09/080902221737.htm (accessed July 31, 2014).

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