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Small Molecule Triggers Bacterial Community

Date:
December 26, 2008
Source:
Harvard Medical School
Summary:
Researchers identify mechanisms behind biofilm formations, with implications for developing new antibiotics.
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While bacterial cells tend to be rather solitary individuals, they are also known to form intricately structured communities called biofilms. But until now, no one has known the mechanisms that cause isolated bacteria to suddenly aggregate into a social network. New insights from the lab of Harvard Medical School microbial geneticist Roberto Kolter reveal previously unknown communication pathways that cause such social phenomenon.

Using the non-pathogenic Bacillus subtilis as a model organism, Kolter and postdoctoral researcher Daniel Lopez discovered a group of natural, soil-based products that trigger communal behavior in bacteria. One molecule in particular, surfactin, is produced by B. subtilis. Biofilm formation begins when surfactin, and other similar molecules, cause bacteria to leak potassium. As potassium levels decline, a membrane protein on the bacterium stimulates a cascade of gene activity that signals neighboring cells to form a quorum. As a result, biofilms form.

The authors note that it's still unclear how biofilm formation benefits the bacteria, and they hypothesize that it might be an antibacterial defense against competing species. Still, the notion that a single small molecule can induce multicellularity intrigues the researchers.

"Typically, scientists try to discover new antibiotics through some rather blunt means, like simply looking to see if one bacterium can kill another," says Kolter. "This discovery of a single molecule causing such a dramatic response in bacteria hints at a new and potentially effective way to possibly discover antibiotics."


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The above post is reprinted from materials provided by Harvard Medical School. Note: Materials may be edited for content and length.


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Harvard Medical School. "Small Molecule Triggers Bacterial Community." ScienceDaily. ScienceDaily, 26 December 2008. <www.sciencedaily.com/releases/2008/12/081222221531.htm>.
Harvard Medical School. (2008, December 26). Small Molecule Triggers Bacterial Community. ScienceDaily. Retrieved July 4, 2015 from www.sciencedaily.com/releases/2008/12/081222221531.htm
Harvard Medical School. "Small Molecule Triggers Bacterial Community." ScienceDaily. www.sciencedaily.com/releases/2008/12/081222221531.htm (accessed July 4, 2015).

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