Featured Research

from universities, journals, and other organizations

Extra Virgin Olive Oil May Help To Combat Breast Cancer

Date:
February 10, 2009
Source:
Universidad de Granada
Summary:
Researchers have verified the bioactivity of the polyphenols present in extra virgin olive oil in breast cancer cell lines. This study confirms the potentiality of polyphenols to inhibit HER2 activity and to promote its degradation.

Bottle of olive oil.
Credit: iStockphoto/Carolina Garcia Aranda

UGR News Researchers of the Catalonian Institute of Oncology (Spain) and the University of Granada (Spain) have discovered that extra virgin olive oil may help to combat breast cancer, according to a paper published in a recent issue of ‘BMC Cancer’. The scientists have confirmed the bioactivity of polyphenols (this is, natural antioxidants) present in olive oil in breast cancer cell lines.

Related Articles


The study has shown the anti-HER2 effect of fractions of phenolic compounds directly extracted from extra virgin olive oil in breast cancer cell lines. They have used solid-phase extraction methods of semi-preparative liquid chromatography to isolate fractions of commercial oils and, later, separation techniques (capillary electrophoresis and liquid chromatography connected to mass spectrometry) to check the purity and composition of the fractions.

Such fractions were tested in their anti-cancer capacity both against positive HER2 and negative HER2 breast cancers, using in Vitro models and evaluating the effect of polyphenolic fractions in the expression and activation of HER2 oncoprotein through ELISA specific methods for HER2. Fractions containing polyphonels such as hydroxitirosol, tirosol, elenolic acid, lignans, pinoresinol and acetopinoresinol, and secoiridoids, diacetox oleuropein aglycone, ligustrosid aglycone and oleuropein aglycone were able to induce important tumoricid effects in a range of micromolar and in a selective way against HER2 oncogene.

Therefore, this study confirms the potentiality of polyphenols to inhibit HER2 activity and to promote its degradation. Such results, together with the fact that humans have consumed secoiridoids and lignans safely for a long time through oil and olive oil consumption, endorse the fact that such phytochemicals could be an excellent and safe basis for the design of new antiHER2 compounds.

This work has been carried out by Javier A. Menéndez, coordinator of the Translational Research Unit of the Catalonian Institute of Oncology (ICO) in Girona, and by doctors Alberto Fernández Gutiérrez –in charge of the “Research Group of Analytic, Environmental, Biochemical and Food Control”- and Antonio Segura Carretero, member of such group.

This Research Group of the Department of Analytical Chemistry of the University of Granada (Spain) has developed other interesting research works in the characterization of polyphenolic profiles of an important number of plants and metabolomic studies of extracts with proved bioactivity through the use of advanced separation techniques.


Story Source:

The above story is based on materials provided by Universidad de Granada. Note: Materials may be edited for content and length.


Cite This Page:

Universidad de Granada. "Extra Virgin Olive Oil May Help To Combat Breast Cancer." ScienceDaily. ScienceDaily, 10 February 2009. <www.sciencedaily.com/releases/2009/02/090205113743.htm>.
Universidad de Granada. (2009, February 10). Extra Virgin Olive Oil May Help To Combat Breast Cancer. ScienceDaily. Retrieved March 2, 2015 from www.sciencedaily.com/releases/2009/02/090205113743.htm
Universidad de Granada. "Extra Virgin Olive Oil May Help To Combat Breast Cancer." ScienceDaily. www.sciencedaily.com/releases/2009/02/090205113743.htm (accessed March 2, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, March 2, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Treadmill Test Can Predict Chance Of Death Within A Decade

Treadmill Test Can Predict Chance Of Death Within A Decade

Newsy (Mar. 2, 2015) — Johns Hopkins researchers analyzed 58,000 heart stress tests to come up with a formula that predicts a person&apos;s chances of dying in the next decade. Video provided by Newsy
Powered by NewsLook.com
Going Gluten-Free Could Get You A Tax Break

Going Gluten-Free Could Get You A Tax Break

Newsy (Mar. 2, 2015) — If a doctor advises you to remove gluten from your diet, you could get a tax deduction on the amount you spend on gluten-free foods. Video provided by Newsy
Powered by NewsLook.com
GlaxoSmithKline and Novartis Try Swapping Success

GlaxoSmithKline and Novartis Try Swapping Success

Reuters - Business Video Online (Mar. 2, 2015) — GlaxoSmithKline and Novartis have completed a series of asset swaps worth more than $20 billion. As Grace Pascoe reports they say the deal will reshape both drugmakers. Video provided by Reuters
Powered by NewsLook.com
How Can West Africa Rebuild After Ebola?

How Can West Africa Rebuild After Ebola?

Reuters - Business Video Online (Mar. 2, 2015) — How best to rebuild the three West African countries struggling with Ebola will be discussed in Brussels this week. As Hayley Platt reports Sierra Leone has the toughest job ahead - its once thriving economy has been ravaged by the disease. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins