Mar. 9, 2009 We know that lifespan can be extended in animals by restricting calories such as sugar intake. Now, according to a study published in the journal PLoS Genetics, Université de Montréal scientists have discovered that it's not sugar itself that is important in this process but the ability of cells to sense its presence.
Aging is a complex phenomenon and the mechanisms underlying aging are yet to be explained. What researchers do know is that there is a clear relationship between aging and calorie intake. For example, mice fed with half the calories they usually eat can live 40 percent longer. How does this work?
As part of the PLoS Genetics study, Université de Montréal Biochemistry Professor Luis Rokeach and his student Antoine Roux discovered to their surprise that if they removed the gene for a glucose sensor from yeast cells, they lived just as long as those living on a glucose-restricted diet. In short, the fate of these cells doesn't depend on what they eat but what they think they're eating.
There are two obvious aspects of calorie intake: tasting and digestion. By the time nutrients get to our cells there is an analogous process: sensors on the surface of the cell detect the presence of, for example, the sugar glucose and molecules inside the cell break down the glucose, converting it to energy. Of these processes, it is widely thought that the by-products of broken down sugars are the culprits in aging. The study by Rokeach and Roux suggests otherwise.
To understand aging, Rokeach and Roux in collaboration with Université de Montréal Biochemistry Professors Pascal Chartrand and Gerardo Ferbeyre used yeast as a model organism. At a basic level, yeast cells are surprisingly similar and age much like human cells, as well as being easy to study.
The research team found that the lifespan of yeast cells increased when glucose was decreased from their diet. They then asked whether the increase in lifespan was due to cells decreasing their ability to produce energy or to the decrease in signal to the cells by the glucose sensor.
The scientists found that cells unable to consume glucose as energy source are still sensitive to the pro-aging effects of glucose. Conversely, obliterating the sensor that measures the levels of glucose significantly increased lifespan.
"Thanks to this study, the link between the rise in age-related diseases and the over-consumption of sugar in today's diet is clearer. Our research opens a door to new therapeutic strategies for fighting age-related diseases," says Professor Rokeach.
Professor Rokeach's research is supported by the Canadian Institutes of Health Research and by the National Science and Engineering Research Council. Professor Ferbeyre's and Professor Chartrand's research are funded by the Canadian Institutes of Health Research.
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- Antoine E. Roux, Alexandre Leroux, Manal A. Alaamery, Charles S. Hoffman, Pascal Chartrand, Gerardo Ferbeyre, Luis A. Rokeach. Pro-Aging Effects of Glucose Signaling through a G Protein-Coupled Glucose Receptor in Fission Yeast. PLoS Genetics, 2009; 5 (3): e1000408 DOI: 10.1371/journal.pgen.1000408
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