Featured Research

from universities, journals, and other organizations

Conserved Gene Expression Reveals Our 'Inner Fish'

Date:
April 16, 2009
Source:
Journal of Biology
Summary:
A study of gene expression in chickens, frogs, pufferfish, mice and people has revealed surprising similarities in several key tissues. Researchers have shown that expression in tissues with a limited number of specialized cell types is strongly conserved, even between the mammalian and non-mammalian vertebrates.

New research shows that the expression of certain specialized genes in vertebrates as different as pufferfish and humans has remained remarkably conserved over evolution.
Credit: iStockphoto/Ernst Daniel Scheffler

A study of gene expression in chickens, frogs, pufferfish, mice and people has revealed surprising similarities in several key tissues. Researchers have shown that expression in tissues with a limited number of specialized cell types is strongly conserved, even between the mammalian and non-mammalian vertebrates.

Related Articles


Timothy Hughes from the University of Toronto, Canada, worked with a team of researchers to investigate evolutionary alterations in gene regulation in the five different vertebrates. They found that although the specialized DNA sequences that regulate the expression of the genes seem to have changed beyond recognition over the hundreds of millions of years since the clades parted evolutionary company, the actual patterns of gene expression remain closely conserved.

According to Hughes, "There are clearly strong evolutionary constraints on tissue-specific gene expression. Many genes show conserved human/fish expression despite having almost no nonexonic conserved primary sequence."

The authors studied 3074 genes that were present as a single unambiguous copy in each of the five genomes. The similar expression profiles they uncovered suggest the existence of a basic ancestral pattern of expression in each tissue, the so-called 'inner fish'.

The strongest similarities were seen in brain tissue. Hughes said, "This relatively low divergence of gene expression in brain supports the hypothesis that neurons participate in more functional interactions than cells in other tissues – imposing constraints on the degree of alteration that can be tolerated". Genes expressed in tissues subject to greater environmental influence (such as intestine, stomach and spleen) may be more likely to take on new roles and diverge in expression as a means of adaptation.

Although this study only investigated vertebrates, these expression profiles may go much further back into our past. The authors conclude, "It is likely that the conservation of gene expression extends beyond the base of vertebrates, coexpression of neuronal genes, for example, has been observed as far as nematodes."


Story Source:

The above story is based on materials provided by Journal of Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Esther T Chan, Gerald T Quon, Gordon Chua, Tomas Babak, Miles Trochesset, Ralph A Zirngibl, Jane Aubin, Michael Ratcliffe, Andrew Wilde, Michael Brudno, Quaid D Morris and Timothy R Hughes. Conservation of core gene expression in vertebrate tissues. Journal of Biology, 2009; DOI: 10.1186/jbiol130

Cite This Page:

Journal of Biology. "Conserved Gene Expression Reveals Our 'Inner Fish'." ScienceDaily. ScienceDaily, 16 April 2009. <www.sciencedaily.com/releases/2009/04/090415193249.htm>.
Journal of Biology. (2009, April 16). Conserved Gene Expression Reveals Our 'Inner Fish'. ScienceDaily. Retrieved April 21, 2015 from www.sciencedaily.com/releases/2009/04/090415193249.htm
Journal of Biology. "Conserved Gene Expression Reveals Our 'Inner Fish'." ScienceDaily. www.sciencedaily.com/releases/2009/04/090415193249.htm (accessed April 21, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, April 21, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Going Ape: Sierra Leone Chimpanzees Hail Ebola Retreat

Going Ape: Sierra Leone Chimpanzees Hail Ebola Retreat

AFP (Apr. 21, 2015) As money runs out at Tacugama Chimpanzee Sanctuary in Sierra Leone, around 85 chimps are facing homelessness. The centre closed when the Ebola epidemic was ravaging the country but now that closure is beginning to look permanent. Video provided by AFP
Powered by NewsLook.com
Blue Bell Recalls All Products

Blue Bell Recalls All Products

AP (Apr. 21, 2015) Blue Bell Creameries voluntary recalled for all of its products after two samples of chocolate chip cookie dough ice cream tested positive for listeria, a potentially deadly bacteria. Blue Bell&apos;s President and CEO issued a video statement. (April 21) Video provided by AP
Powered by NewsLook.com
Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Research Says Complex Tools Might Not Be 'Our Thing' Anymore

Newsy (Apr. 21, 2015) The use of complex tools has often been seen as a defining characteristic of humanity, but that notion is now in question. Video provided by Newsy
Powered by NewsLook.com
Deepwater And Dolphins: The Oil Spill's Impact 5 Years On

Deepwater And Dolphins: The Oil Spill's Impact 5 Years On

Newsy (Apr. 20, 2015) Five years on, the possible environmental impact of the Deepwater Horizon spill includes a sustained die-off of bottlenose dolphins, among others. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins