Featured Research

from universities, journals, and other organizations

Neurological Disorder In Golden Retriever Dogs Caused By A Mutation In Mitochondrial DNA

Date:
May 30, 2009
Source:
Public Library of Science
Summary:
Sensory ataxic neuropathy (SAN) is a recently identified neurological disorder in Golden Retriever dogs with onset during puppyhood. Affected dogs move in an uncoordinated manner and have sensory deficits. Researchers in Sweden have now revealed that SAN is caused by a mutation in mitochondrial DNA.

Researchers in Sweden have figured out the basis for a neurological disorder in Golden Retriever dogs called sensory ataxic neuropathy.
Credit: iStockphoto/Dale Miller

Sensory ataxic neuropathy (SAN) is a recently identified neurological disorder in Golden Retriever dogs with onset during puppyhood. Affected dogs move in an uncoordinated manner and have sensory deficits. Researchers from the Swedish University of Agricultural Sciences, Uppsala University and the Karolinska Institutet have now revealed that SAN is caused by a mutation in mitochondrial DNA.

The study is published May 29 in the open-access journal PLoS Genetics.

The researchers were able to trace back all affected offspring on the maternal side, over more than 10 generations, to a female that lived during the 1970s. This implied a maternal inheritance, which was confirmed by the identification of a one base pair deletion in the mitochondrial tRNA-Tyr gene. Further analyses revealed that the mutation leads to mitochondrial dysfunction, which in turn causes a progressive loss of neurons.

The researchers showed that about five percent of the current Swedish Golden Retriever population carries the mutation causing SAN. The identification of the mutation now allows genetic screening tests to identify carriers and prevent the mutation being transmitted to further generations.

"This is a good example of how a close collaboration between clinicians and geneticists led to a rapid detection of a harmful mutation that can now be eliminated from this dog population to reduce suffering and disease," said co-author Karin Hultin Jδderlund. The study also provides a new animal model for similar mitochondrial disorders in humans, said co-author Izabella Baranowska, and could potentially be used for testing therapeutic approaches.


Story Source:

The above story is based on materials provided by Public Library of Science. Note: Materials may be edited for content and length.


Journal Reference:

  1. Baranowska I, Jδderlund KH, Nennesmo I, Holmqvist E, Heidrich N, et al. Sensory Ataxic Neuropathy in Golden Retriever Dogs Is Caused by a Deletion in the Mitochondrial tRNATyr Gene. PLoS Genetics, 2009; 5 (5): e1000499 DOI: 10.1371/journal.pgen.1000499

Cite This Page:

Public Library of Science. "Neurological Disorder In Golden Retriever Dogs Caused By A Mutation In Mitochondrial DNA." ScienceDaily. ScienceDaily, 30 May 2009. <www.sciencedaily.com/releases/2009/05/090528203728.htm>.
Public Library of Science. (2009, May 30). Neurological Disorder In Golden Retriever Dogs Caused By A Mutation In Mitochondrial DNA. ScienceDaily. Retrieved September 23, 2014 from www.sciencedaily.com/releases/2009/05/090528203728.htm
Public Library of Science. "Neurological Disorder In Golden Retriever Dogs Caused By A Mutation In Mitochondrial DNA." ScienceDaily. www.sciencedaily.com/releases/2009/05/090528203728.htm (accessed September 23, 2014).

Share This



More Plants & Animals News

Tuesday, September 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Raw: Ice Age Wooly Mammoth Remains for Sale

Raw: Ice Age Wooly Mammoth Remains for Sale

AP (Sep. 23, 2014) — A rare, well-preserved skeleton of a woolly mammoth is going on sale at Summers Place Auctions hope the 11.5-foot tall, almost intact specimen will fetch between $245,000 to $409,000. (Sept. 23) Video provided by AP
Powered by NewsLook.com
Fox Bites Conn. Student And School Staffers In Rare Attack

Fox Bites Conn. Student And School Staffers In Rare Attack

Newsy (Sep. 23, 2014) — A fox attacked a second-grade boy at a Connecticut elementary school Monday. It also attacked two school staff members and a woman and her dog. Video provided by Newsy
Powered by NewsLook.com
Will Living Glue Be A Thing?

Will Living Glue Be A Thing?

Newsy (Sep. 23, 2014) — Using proteins derived from mussels, engineers at MIT have made a supersticky underwater adhesive. They're now looking to make "living glue." Video provided by Newsy
Powered by NewsLook.com
Raw: Tiger Kills Man at India Zoo

Raw: Tiger Kills Man at India Zoo

AP (Sep. 23, 2014) — A white tiger killed a young man who climbed over a fence at the New Delhi zoo and jumped into the animal's enclosure on Tuesday, a spokesman said. (Sept. 23) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins