Featured Research

from universities, journals, and other organizations

Heme Proteins: Ubiquitous And Essential For Every Organism

Date:
June 12, 2009
Source:
University of Leicester
Summary:
Research in chemical biology shows how protein engineering techniques can be used to examine the function of heme enzymes.

Research at the chemistry-biology interface has been a major strength in Leicester for many years. Scientists at the Henry Wellcome Building for Biomedical Research have been bringing together equipment, staff and ideas in an attempt to establish a multidisciplinary approach to better study the structure, kinetics and function of biological systems.

Related Articles


On Wednesday 17th June, Dr Pipirou will present the key findings of her Ph.D. research in which she studied the function and mechanism of formation of covalent links inside heme proteins. Carried out in Professor Emma Raven’s lab, Dr Pipirou’s research involved using techniques at the interface between the traditional chemistry and biology disciplines to engineer covalent links, physiologically seen in mammalian proteins, into members of their plant counterparts.

Dr Pipirou’s doctoral research has given valuable insight into the similarities and differences between plant and mammalian heme proteins and has shown that plant proteins can be used as model systems to study the characteristics and function of complex mammalian systems. Dr Pipirou was recently presented with the Royal Society of Chemistry’s 2008 Laurie Vergnano Award, in recognition of her research in this field.

Dr Pipirou commented: ‘Heme, is an iron-containing molecule that is an integral component of many proteins, so-called hemoproteins, in bacteria, plants and animals. It is the component of hemoglobin that gives blood its red color. Heme proteins display a wide range of biological functions; for example, hemoglobin and myoglobin are able to maintain a balanced supply of oxygen by functioning as oxygen transport and binding proteins.’

‘Although the heme is non-covalently bound to many of these proteins, it is now becoming clear that a large number of other proteins use modified versions of heme in which the heme is covalently linked to the protein. The most striking example of such a protein is myeloperoxidase, a member of the mammalian peroxidases, which bears three heme-protein covalent bonds. My Phd work was based on examining how these links are made across different families of heme proteins.’

She said: ‘I will present the type of heme-protein links that we can engineer into plant peroxidases and demonstrate how plant proteins can use the same chemistry and mechanisms that we see for mammalian enzymes. Most importantly, I will discuss what nature has to gain by supporting formation of such heme-protein links or even by “switching them off”.’

Dr Pipirou was recently presented with the Royal Society of Chemistry’s 2008 Laurie Vergnano Award, in recognition of her research in this field.


Story Source:

The above story is based on materials provided by University of Leicester. Note: Materials may be edited for content and length.


Cite This Page:

University of Leicester. "Heme Proteins: Ubiquitous And Essential For Every Organism." ScienceDaily. ScienceDaily, 12 June 2009. <www.sciencedaily.com/releases/2009/06/090612123914.htm>.
University of Leicester. (2009, June 12). Heme Proteins: Ubiquitous And Essential For Every Organism. ScienceDaily. Retrieved October 24, 2014 from www.sciencedaily.com/releases/2009/06/090612123914.htm
University of Leicester. "Heme Proteins: Ubiquitous And Essential For Every Organism." ScienceDaily. www.sciencedaily.com/releases/2009/06/090612123914.htm (accessed October 24, 2014).

Share This



More Matter & Energy News

Friday, October 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

3D Printed Instruments Make Sweet Music in Sweden

3D Printed Instruments Make Sweet Music in Sweden

Reuters - Innovations Video Online (Oct. 23, 2014) Students from Lund University's Malmo Academy of Music are believed to be the world's first band to all use 3D printed instruments. The guitar, bass guitar, keyboard and drums were built by Olaf Diegel, professor of product development, who says 3D printing allows musicians to design an instrument to their exact specifications. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Chameleon Camouflage to Give Tanks Cloaking Capabilities

Chameleon Camouflage to Give Tanks Cloaking Capabilities

Reuters - Innovations Video Online (Oct. 22, 2014) Inspired by the way a chameleon changes its colour to disguise itself; scientists in Poland want to replace traditional camouflage paint with thousands of electrochromic plates that will continuously change colour to blend with its surroundings. The first PL-01 concept tank prototype will be tested within a few years, with scientists predicting that a similar technology could even be woven into the fabric of a soldiers' clothing making them virtually invisible to the naked eye. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Jet Sales Lift Boeing Profit 18 Pct.

Jet Sales Lift Boeing Profit 18 Pct.

Reuters - Business Video Online (Oct. 22, 2014) Strong jet demand has pushed Boeing to raise its profit forecast for the third time, but analysts were disappointed by its small cash flow. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
Internet of Things Aims to Smarten Your Life

Internet of Things Aims to Smarten Your Life

AP (Oct. 22, 2014) As more and more Bluetooth-enabled devices are reaching consumers, developers are busy connecting them together as part of the Internet of Things. (Oct. 22) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Space & Time

Matter & Energy

Computers & Math

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins