Featured Research

from universities, journals, and other organizations

'Artificial Golgi' May Provide New Insight Into Key Cell Structure

Date:
August 3, 2009
Source:
American Chemical Society
Summary:
Scientists are reporting assembly of the first functioning prototype of an artificial Golgi organelle. That key structure inside cells helps process and package hormones, enzymes, and other substances that allow the body to function normally.

Researchers have developed an artificial version of the Golgi organelle, shown in this illustration of a cell cross-section. The device could lead to a better method for producing heparin, they say.
Credit: The American Chemical Society

Scientists in New York and North Carolina are reporting assembly of the first functioning prototype of an artificial Golgi organelle. That key structure inside cells helps process and package hormones, enzymes, and other substances that allow the body to function normally. The lab-on-a-chip device could lead to a faster and safer method for producing heparin, the widely used anticoagulant or blood thinner, the researchers note.

The Golgi organelle is named for Camillo Golgi, the Italian scientist and Nobel Prize winner who discovered the structure in 1898. It is composed of a network of sacs, stacked like a deck of playing cards, located inside cells. In the new study, Robert Linhardt and colleagues point out that Golgi bodies are one of the most poorly understood organelles (specialized structures inside cells) in the human body. Scientists already know, however, that the organelles play a key role in producing heparin, a substance that helps prevent clotting.

The researchers describe development of a prototype lab-on-a-chip device that closely mimics the natural Golgi apparatus. They showed in lab tests that the device could quickly and efficiently produce heparin. It did so in an assembly-line fashion using a combination of enzymes, sugars and other raw materials and demonstrated that the substance has a strong clot-fighting potential. In the future, an "artificial Golgi" could lead to a faster and safer method for producing heparin, the scientists suggest.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Martin et al. Toward an Artificial Golgi: Redesigning the Biological Activities of Heparan Sulfate on a Digital Microfluidic Chip. Journal of the American Chemical Society, 2009; 090710133727034 DOI: 10.1021/ja903038d

Cite This Page:

American Chemical Society. "'Artificial Golgi' May Provide New Insight Into Key Cell Structure." ScienceDaily. ScienceDaily, 3 August 2009. <www.sciencedaily.com/releases/2009/07/090729103732.htm>.
American Chemical Society. (2009, August 3). 'Artificial Golgi' May Provide New Insight Into Key Cell Structure. ScienceDaily. Retrieved July 22, 2014 from www.sciencedaily.com/releases/2009/07/090729103732.htm
American Chemical Society. "'Artificial Golgi' May Provide New Insight Into Key Cell Structure." ScienceDaily. www.sciencedaily.com/releases/2009/07/090729103732.htm (accessed July 22, 2014).

Share This




More Plants & Animals News

Tuesday, July 22, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Michigan Plant's Goal: Flower and Die

Michigan Plant's Goal: Flower and Die

AP (July 22, 2014) An 80-year-old agave plant, which is blooming for the first and only time at a University of Michigan conservatory, will die when it's done (July 22) Video provided by AP
Powered by NewsLook.com
San Diego Zoo Welcomes New, Rare Rhino Calf

San Diego Zoo Welcomes New, Rare Rhino Calf

Reuters - US Online Video (July 21, 2014) An endangered black rhino baby is the newest resident at the San Diego Zoo. Sasha Salama reports. Video provided by Reuters
Powered by NewsLook.com
Shark Sightings a Big Catch for Cape Tourism

Shark Sightings a Big Catch for Cape Tourism

AP (July 21, 2014) A rise in shark sightings along the shores of Chatham, Massachusetts is driving a surge of eager vacationers to the beach town looking to catch a glimpse of a great white. (July 21) Video provided by AP
Powered by NewsLook.com
$23.6 Billion Awarded To Widow In Smoking Lawsuit

$23.6 Billion Awarded To Widow In Smoking Lawsuit

Newsy (July 20, 2014) Cynthia Robinson claims R.J. Reynolds Tobacco Company hid the health and addiction risks of its products, leading to the death of her husband in 1996. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins