Featured Research

from universities, journals, and other organizations

New Location Found For Regulation Of RNA Fate

Date:
August 1, 2009
Source:
University of Wisconsin-Madison
Summary:
Thousands of scientists and hundreds of software programmers studying the process by which RNA inside cells normally degrades may soon broaden their focus significantly. Researchers have discovered that the RNA degradation, which, when improperly regulated can lead to cancer and other diseases, can be launched in an unexpected location.

Thousands of scientists and hundreds of software programmers studying the process by which RNA inside cells normally degrades may soon broaden their focus significantly.

Related Articles


That's because University of Wisconsin-Madison researchers have discovered that the RNA degradation, which, when improperly regulated can lead to cancer and other diseases, can be launched in an unexpected location.

"We've been seeing only half the picture," says Vladimir Spiegelman, lead author on the new study and associate professor of dermatology at the UW-Madison School of Medicine and Public Health.

The Wisconsin team also found that CRD-BP, a protein activated in colorectal and other cancers, can prevent RNA from degrading in the newly identified spot.

The finding may have broad implications for cancer research as well as biology in general.

"The finding is important for the proto-oncogenes, or precursor cancer genes, we study, but it may be even more important for the thousands of other genes and proteins that are regulated in a similar way," says Spiegelman.

The study appears in the July 31 issue of Molecular Cell.

Spiegelman and his team study proto-oncogenes and other potential "cancer-causers" normally found in cells, analyzing them as they are "converted" from DNA into RNA and ultimately active proteins that can lead to cancer.

It's the same multistep process all genes in a cell — including "cancer-preventers" such as tumor suppressors, anti-inflammatory factors and cell death promoters — go through.

Controls at each step usually keep the process working smoothly, but if a control fails at any number of places along the way, a cancer-promoting gene can tilt the delicately balanced scale toward malignancy.

In their previous work, the Wisconsin researchers found that regulation of some proto-oncogenes occurs after CRD-BP binds to messenger RNA (mRNA). During this intermediary step, mRNA is typically either degraded or goes on unharmed to the next step of translation. The Wisconsin team showed that the mRNA bound by CRD-BP was not degraded, and thus became an active protein — in this case, a full-fledged cancer-causing oncogene.

Until the Spiegelman group's latest study appeared, scientists assumed that the regulation of mRNA fate took place exclusively in an area of the RNA strand called the 3 prime untranslated region, where small regulatory RNAs called microRNAs (miRNA) bind and inhibit mRNAs.

But the Wisconsin team found degradation can also be initiated in an area on the mRNA strand called the coding region.

"This changes the paradigm," says Spiegelman. "Now we can examine this important activity in two places."

The researchers demonstrated that degradation occurs here using a human mRNA, and described the mechanism by which CRD-BP stabilizes the mRNA and prevents it from degrading and expressing more protein.

"This may be the first example of a negative regulator of an miRNA-dependent RNA-degrading mechanism," Spiegelman says.

The mechanism is relevant to many proteins, he says.

"Understanding this mechanism should also help us in studying cell signaling pathways related to pro-inflammatory and cell death factors that contribute to tumor development," he says.


Story Source:

The above story is based on materials provided by University of Wisconsin-Madison. Note: Materials may be edited for content and length.


Cite This Page:

University of Wisconsin-Madison. "New Location Found For Regulation Of RNA Fate." ScienceDaily. ScienceDaily, 1 August 2009. <www.sciencedaily.com/releases/2009/07/090730121039.htm>.
University of Wisconsin-Madison. (2009, August 1). New Location Found For Regulation Of RNA Fate. ScienceDaily. Retrieved February 27, 2015 from www.sciencedaily.com/releases/2009/07/090730121039.htm
University of Wisconsin-Madison. "New Location Found For Regulation Of RNA Fate." ScienceDaily. www.sciencedaily.com/releases/2009/07/090730121039.htm (accessed February 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, February 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Sleeping Too Much Or Too Little Might Increase Stroke Risk

Newsy (Feb. 26, 2015) People who sleep more than eight hours per night are 45 percent more likely to have a stroke, according to a University of Cambridge study. Video provided by Newsy
Powered by NewsLook.com
London Show Dissects History of Forensic Science

London Show Dissects History of Forensic Science

AFP (Feb. 25, 2015) Forensic science, which has fascinated generations with its unravelling of gruesome crime mysteries, is being put under the microscope in an exhibition of real criminal investigations in London. Duration: 00:53 Video provided by AFP
Powered by NewsLook.com
Michigan Couple Celebrates Identical Triplets

Michigan Couple Celebrates Identical Triplets

AP (Feb. 25, 2015) A suburban Detroit couple who have two older children are adjusting to life after becoming parents to identical triplets _ a multiple birth a doctor calls rare. (Feb. 25) Video provided by AP
Powered by NewsLook.com
Mayor Says District of Columbia to Go Ahead With Pot Legalization

Mayor Says District of Columbia to Go Ahead With Pot Legalization

Reuters - News Video Online (Feb. 25, 2015) Washington&apos;s mayor says the District of Columbia will move forward with marijuana legalization, despite pushback from Congress. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins