Featured Research

from universities, journals, and other organizations

Enzyme That Causes Genetic Diseases Investigated

Date:
August 18, 2009
Source:
Basque Research
Summary:
Researchers have conducted a research project to gain in-depth knowledge of the structure of pyruvate carboxylase when it is in solution (in the "natural" state). Pyruvate carboxylase is a metabolic enzyme that plays a fundamental role in the metabolism of fatty acids (the components of fats) and sugars. When its function is not adequately performed (for example, when mutations in the gene arise) diverse metabolic diseases of genetic origin are triggered, amongst them lactic acidaemia, hypoglycaemia, and psycho-motor retardation.

Researchers from CIC bioGUNE's Structural Biology Unit and Columbia University (New York) have conducted a joint research project, published in the journal Structure, to gain in-depth knowledge of the structure of pyruvate carboxylase when it is in solution (in the "natural" state).

Pyruvate carboxylase is a metabolic enzyme that plays a fundamental role in the metabolism of fatty acids (the components of fats) and sugars. When its function is not adequately performed (for example, when mutations in the gene arise) diverse metabolic diseases of genetic origin are triggered, amongst them lactic acidaemia, hypoglycaemia, and psycho-motor retardation. At the same time, being at a metabolic crossroads, pyruvate carboxylase is potentially a target in obesity and diabetes treatments.

The paper presents the enzyme's structure under physiological conditions for the first time, and reveals which of the previous models is the correct one.

Mikel Valle, a researcher from CIC bioGUNE's Structural Biology Unit explains that This is the start of a highly ambitious study which is being carried out at CIC bioGUNE and which aims to discover the functioning of pyruvate carboxylase. This they shall achieve by observing its structure throughout its functional cycle, in the hope of discovering its structure in each of the steps it follows during its functioning.

The project has been conducted together with the New York Structural Biology Center (NYSBC). Set up in 2002, this Center uses the most advanced Molecular Magnetic Resonance imaging, Electron Microscopy, and X-ray crystallography equipment (as does CIC bioGUNE's Structural Biology Unit). In this joint research project, the NYSBC took charge of the X-ray crystallography part, while CIC bioGUNE's Structural Biology Unit has undertaken the Electron Microscopy part.


Story Source:

The above story is based on materials provided by Basque Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. Linda P.C. Yu, Song Xiang, Gorka Lasso, David Gil, Mikel Valle and Liang Tong. A Symmetrical Tetramer for S. aureus Pyruvate Carboxylase in Complex with Coenzyme A. Structure, Online 9 June 2009 DOI: 10.1016/j.str.2009.04.008

Cite This Page:

Basque Research. "Enzyme That Causes Genetic Diseases Investigated." ScienceDaily. ScienceDaily, 18 August 2009. <www.sciencedaily.com/releases/2009/08/090805075755.htm>.
Basque Research. (2009, August 18). Enzyme That Causes Genetic Diseases Investigated. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2009/08/090805075755.htm
Basque Research. "Enzyme That Causes Genetic Diseases Investigated." ScienceDaily. www.sciencedaily.com/releases/2009/08/090805075755.htm (accessed April 23, 2014).

Share This



More Health & Medicine News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Big Pharma Braces for M&A Wave

Big Pharma Braces for M&A Wave

Reuters - Business Video Online (Apr. 22, 2014) Big pharma on the move as Novartis boss, Joe Jimenez, tells Reuters about plans to transform his company via an asset exchange with GSK, and Astra Zeneca shares surge on speculation that Pfizer is looking for a takeover. Joanna Partridge reports. Video provided by Reuters
Powered by NewsLook.com
How Smaller Plates And Cutlery Could Make You Feel Fuller

How Smaller Plates And Cutlery Could Make You Feel Fuller

Newsy (Apr. 22, 2014) NBC's "Today" conducted an experiment to see if changing the size of plates and utensils affects the amount individuals eat. Video provided by Newsy
Powered by NewsLook.com
How to Master Motherhood With the Best Work/Life Balance

How to Master Motherhood With the Best Work/Life Balance

TheStreet (Apr. 22, 2014) In the U.S., there are more than 11 million couples trying to conceive at any given time. From helping celebrity moms like Bethanny Frankel to ordinary soon-to-be-moms, TV personality and parenting expert, Rosie Pope, gives you the inside scoop on mastering motherhood. London-born entrepreneur Pope is the creative force behind Rosie Pope Maternity and MomPrep. She explains why being an entrepreneur offers the best life balance for her and tips for all types of moms. Video provided by TheStreet
Powered by NewsLook.com
Catching More Than Fish: Ugandan Town Crippled by AIDS

Catching More Than Fish: Ugandan Town Crippled by AIDS

AFP (Apr. 22, 2014) The village of Kasensero on the shores of Lake Victoria was where HIV-AIDS was first discovered in Uganda. Its transient population of fishermen and sex workers means the nationwide programme to combat the virus has had little impact. Duration: 02:30 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins