Featured Research

from universities, journals, and other organizations

Genomic Study Yields Plausible Cause Of Colony Collapse Disorder

Date:
August 25, 2009
Source:
University of Illinois at Urbana-Champaign
Summary:
Researchers have found a surprising but reliable marker of colony collapse disorder, a baffling malady that in 2007-2008 killed off more than a third of commercial honey bees in the US. Their study is the first to identify a single, objective molecular marker of the disorder, and to propose a data-driven hypothesis to explain the mysterious disappearance of American honey bees.

Bees in CCD hives have unusually high levels of ribosomal fragments, a symptom of infection with multiple picorna-like viruses, the researchers found.
Credit: L. Brian Stauffer, University of Illinois News Bureau

Researchers report this week that they have found a surprising but reliable marker of colony collapse disorder, a baffling malady that in 2007-2008 killed off more than a third of commercial honey bees in the U.S.

Related Articles


Their study, in the Proceedings of the National Academy of Sciences, is the first to identify a single, objective molecular marker of the disorder, and to propose a data-driven hypothesis to explain the mysterious disappearance of American honey bees. The team included researchers from the University of Illinois and the U.S. Department of Agriculture.

U. of I. researchers spearheaded the honey bee genome project, which was completed in October 2006, less than a month before the first reports of colony collapse disorder (CCD) began to circulate. The new study made use of the genome and a genome-based tool, the microarray, to look for differences in gene expression in the guts of healthy honey bees and in those from hives afflicted by CCD.

Such microarray analyses normally identify only active genes – those that have been transcribed into messenger RNA in the first stage of building proteins. But Reed Johnson, a University of Illinois doctoral student in entomology and first author on the study, noticed that the microarrays were turning up large quantities of fragmented ribosomal RNA (rRNA) in the bees affected by CCD. Ribosomes are the factories in which proteins are made, but Johnson observed that this rRNA contained adenosine-rich sequences not seen in normal ribosomes. Such "polyadenylation" is believed to be a sign of ribosome degradation.

"Microarrays for other organisms also contain these mysterious pieces of ribosomal RNA, for reasons that are not yet altogether clear," said entomology and neuroscience professor Gene Robinson, a co-principal investigator on the study with entomology professor and department head May Berenbaum. But comparisons of healthy bees and bees from hives afflicted with CCD showed that the fragments were present at a much higher frequency in the CCD bees, he said.

"They are overrepresented in the CCD bees, significantly overrepresented," Berenbaum said. "The one consistent indicator of CCD across samples collected at multiple times and in multiple places was the overabundance of ribosomal fragments."

When the team looked at the pathogens of healthy bees and bees from hives affected by CCD, they saw that the CCD bees suffered "more than their share" of infections with viruses that attack the ribosome, Berenbaum said. These so-called picorna-like viruses "hijack the ribosome," she said, taking over the cellular machinery to manufacture only viral proteins. The list of picorna-like viruses that afflict honey bees is long and includes Israeli acute paralysis virus, which was once suspected of being the primary cause of CCD.

Numerous suspects have been identified in the hunt for a cause of CCD, from nutritional deficiencies to exposure to genetically modified plants or pesticides. Researchers in Spain recently pointed to a parasitic fungus, Nosema ceranae, which afflicts many CCD bees in Spain.

The loss of ribosomal function would explain many of the phenomena associated with CCD, Berenbaum said.

"If your ribosome is compromised, then you can't respond to pesticides, you can't respond to fungal infections or bacteria or inadequate nutrition because the ribosome is central to the survival of any organism. You need proteins to survive," she said.

The varroa mite, which is believed to have killed off a significant number of honey bees after it was accidentally introduced to the U.S. in 1986, is a carrier of picorna-like viruses, and is likely a significant contributor to the high viral pathogen load that afflicts U.S. bees. The mite may act as a tipping factor leading to ribosome breakdown, the researchers said.

All of these influences, along with the practice of carting bees around the country for pollination services, are significant stressors on the bees, a heavy burden that would be amplified by a loss of ribosomal function, Robinson said.

This study was supported by the USDA. Berenbaum is also an affiliate of the Institute for Genomic Biology at Illinois. Robinson directs the Neuroscience Program at Illinois and is a faculty member of IGB.


Story Source:

The above story is based on materials provided by University of Illinois at Urbana-Champaign. Note: Materials may be edited for content and length.


Cite This Page:

University of Illinois at Urbana-Champaign. "Genomic Study Yields Plausible Cause Of Colony Collapse Disorder." ScienceDaily. ScienceDaily, 25 August 2009. <www.sciencedaily.com/releases/2009/08/090824151256.htm>.
University of Illinois at Urbana-Champaign. (2009, August 25). Genomic Study Yields Plausible Cause Of Colony Collapse Disorder. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/08/090824151256.htm
University of Illinois at Urbana-Champaign. "Genomic Study Yields Plausible Cause Of Colony Collapse Disorder." ScienceDaily. www.sciencedaily.com/releases/2009/08/090824151256.htm (accessed October 25, 2014).

Share This



More Plants & Animals News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins