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New Study Suggests An Unidentified Source As Cause Of Residual Viremia In HIV-1 Patients On HAART

Date:
August 31, 2009
Source:
American Society for Microbiology
Summary:
A new study suggests that an unidentified cellular source may be responsible for residual viremia in HIV-1 patients on highly active antiretroviral therapy (HAART). This discovery disputes previous theories that attributed residual viremia to latent proviruses in resting CD4+ T cells and could significantly impact eradication efforts.

A new study suggests that an unidentified cellular source may be responsible for residual viremia in HIV-1 patients on highly active antiretroviral therapy (HAART). This discovery disputes previous theories that attributed residual viremia to latent proviruses in resting CD4+ T cells and could significantly impact eradication efforts.

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The researchers from The Johns Hopkins University School of Medicine, Baltimore, Maryland; The University of Texas, Austin; and the Howard Hughes Medical Institute, Baltimore, Maryland report their findings in the September 2009 issue of the Journal of Virology.

When successful, HAART can reduce HIV-1 levels in the blood to undetectable amounts, however, HIV-1 still persists as latent proviruses in resting CD4+ T cells, also known as residual viremia. Current eradication strategies have focused on these latent T cell reservoirs, however, treatment failure has prompted researchers to examine other cellular reservoirs as potential sources of residual viremia.

Using two different methods, researchers analyzed viral sequences from individual patients to determine whether residual viremia was stemming from a source other than latent resting CD4+ T cells. Results showed residual viremia to be genetically distinct from proviruses in activated CD4+ T cells.

"The finding that some of the residual viremia in patients on HAART stems from an unidentified cellular source other than CD4+ T cells has implications for eradication efforts," say the researchers.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. T.P. Brennan, J.O. Woods, A.R. Sedaghat, J.D. Siliciano, R.F. Siliciano, C.O. Wilke. Analysis of Human Immunodeficiency Virus Type 1 Viremia and Provirus in Resting CD4 T Cells Reveals a Novel Source of Residual Viremia in Patients on Antiretroviral Therapy. Journal of Virology, 2009; 83 (17): 8470 DOI: 10.1128/JVI.02568-08

Cite This Page:

American Society for Microbiology. "New Study Suggests An Unidentified Source As Cause Of Residual Viremia In HIV-1 Patients On HAART." ScienceDaily. ScienceDaily, 31 August 2009. <www.sciencedaily.com/releases/2009/08/090825082656.htm>.
American Society for Microbiology. (2009, August 31). New Study Suggests An Unidentified Source As Cause Of Residual Viremia In HIV-1 Patients On HAART. ScienceDaily. Retrieved January 30, 2015 from www.sciencedaily.com/releases/2009/08/090825082656.htm
American Society for Microbiology. "New Study Suggests An Unidentified Source As Cause Of Residual Viremia In HIV-1 Patients On HAART." ScienceDaily. www.sciencedaily.com/releases/2009/08/090825082656.htm (accessed January 30, 2015).

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