Featured Research

from universities, journals, and other organizations

Turning Bacteria Into Protein Production Factories

Date:
September 10, 2009
Source:
Society for General Microbiology
Summary:
By adapting a single protein on the surface of the bacterium Caulobacter crescentus, researchers have turned it into a protein production factory, making useful proteins that can act as vaccines and drugs.

By adapting a single protein on the surface of the bacterium Caulobacter crescentus, researchers at the University of British Columbia have turned it into a protein production factory, making useful proteins that can act as vaccines and drugs.

Dr. John Smit presented the findings at the Society for General Microbiology's meeting at Heriot-Watt University, Edinburgh, Sept. 7.

C. crescentus is a harmless bacterium that has a single protein layer on its surface. Dr Smit's team adapted the system that secretes this protein, which self-assembles into a structure called the "S-layer", to secrete instead many proteins that are useful for vaccines and other therapeutic purposes. Or, by keeping the S-layer protein intact and genetically inserting new things inside it, they produce a very dense display of useful proteins on the cell surface and then expect to use the entire bacterium in a therapeutic application.

Bacteria are commonly used in biotechnology to produce useful protein products. If the bacteria secrete the protein rather than keep it contained within the cell, purification costs are greatly lowered. The researchers have developed a commercially available kit based on this technology, which could be especially useful in developing countries as it might be used to manufacture HIV-blocking agents very cheaply and with little specialist expertise.

"This S-layer system is very efficient at producing and secreting proteins – we can make the bacterium into a protein pump, secreting over half of all the protein it makes as engineered S-layer protein," said Dr Smit, "Applications of S-layer display that we are currently developing include anti-cancer vaccines, an HIV infection blocker and agents to treat Crohn's and colitis, and diarrhoea in malnourished populations".


Story Source:

The above story is based on materials provided by Society for General Microbiology. Note: Materials may be edited for content and length.


Cite This Page:

Society for General Microbiology. "Turning Bacteria Into Protein Production Factories." ScienceDaily. ScienceDaily, 10 September 2009. <www.sciencedaily.com/releases/2009/09/090907013809.htm>.
Society for General Microbiology. (2009, September 10). Turning Bacteria Into Protein Production Factories. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/09/090907013809.htm
Society for General Microbiology. "Turning Bacteria Into Protein Production Factories." ScienceDaily. www.sciencedaily.com/releases/2009/09/090907013809.htm (accessed September 2, 2014).

Share This




More Plants & Animals News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Sharks Off the Menu and on the Tourist Trail in Palau

Sharks Off the Menu and on the Tourist Trail in Palau

AFP (Sep. 2, 2014) — Tourists in Palau clamour to dive with sharks thanks to a pioneering conservation initiative -- as the island nation plans to completely ban commercial fishing in its vast ocean territory. 01:15 Video provided by AFP
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com
Coffee Then Napping: The (New) Key To Alertness

Coffee Then Napping: The (New) Key To Alertness

Newsy (Aug. 30, 2014) — Researchers say having a cup of coffee then taking a nap is more effective than a nap or coffee alone. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins