Featured Research

from universities, journals, and other organizations

Taking Sharper Aim At Stomach Ulcer Bacteria

Date:
September 30, 2009
Source:
American Chemical Society
Summary:
Scientists are reporting discovery of a much sought after crack in the armor of a common microbe that infects the stomachs of one-sixth of the world's population, causing stomach ulcers and other diseases. They identified a group of substances that block a key chemical pathway that the bacteria need for survival.

Electron micrograph of H. pylori.
Credit: Yutaka Tsutsumi, M.D. Professor Department of Pathology Fujita Health University School of Medicine / Courtesy of Wikimedia Commons

Scientists are reporting discovery of a much sought after crack in the armor of a common microbe that infects the stomachs of one-sixth of the world's population, causing stomach ulcers and other diseases. They identified a group of substances that block a key chemical pathway that the bacteria need for survival.

Their study, which could lead to new, more effective antibiotics to fight these hard-to-treat microbes, is scheduled for the October 16 issue of ACS Chemical Biology, a monthly journal.

Javier Sancho and colleagues note in the new study that Helicobacter pylori (H. pylori) bacteria infect the stomach lining and can cause gastritis and ulcers. Treatment with broad-spectrum antibiotics can cure H. pylori infections. However, an estimated one billion people remain infected worldwide because of the cost of existing antibiotics and the emergence of antibiotic resistant strains of the bacteria, the researchers say.

The scientists knew from past research that blocking flavodoxin, a key protein that H. pylori needs for survival, could be the key to developing narrow-spectrum antibiotics that specifically target H. pylori. Sancho's team screened 10,000 chemicals for their ability to block flavodoxin and identified four that showed promise. They then showed that three of the four substances killed H. pylori in cell cultures and did not have any apparent toxic effects in lab animals. "These new inhibitors constitute promising candidates to develop new specific antibiotics against H. pylori," the study states.


Story Source:

The above story is based on materials provided by American Chemical Society. Note: Materials may be edited for content and length.


Journal Reference:

  1. Cremades et al. Discovery of Specific Flavodoxin Inhibitors as Potential Therapeutic Agents against Helicobacter pylori Infection. ACS Chemical Biology, 2009; 090922083712023 DOI: 10.1021/cb900166q

Cite This Page:

American Chemical Society. "Taking Sharper Aim At Stomach Ulcer Bacteria." ScienceDaily. ScienceDaily, 30 September 2009. <www.sciencedaily.com/releases/2009/09/090930112142.htm>.
American Chemical Society. (2009, September 30). Taking Sharper Aim At Stomach Ulcer Bacteria. ScienceDaily. Retrieved September 2, 2014 from www.sciencedaily.com/releases/2009/09/090930112142.htm
American Chemical Society. "Taking Sharper Aim At Stomach Ulcer Bacteria." ScienceDaily. www.sciencedaily.com/releases/2009/09/090930112142.htm (accessed September 2, 2014).

Share This




More Health & Medicine News

Tuesday, September 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

U.N. Says Ebola Travel Restrictions Will Cause Food Shortage

Newsy (Sep. 2, 2014) — The U.N. says the problem is two-fold — quarantine zones and travel restrictions are limiting the movement of both people and food. Video provided by Newsy
Powered by NewsLook.com
Get on Your Bike! London Cycling Popularity Soars Despite Danger

Get on Your Bike! London Cycling Popularity Soars Despite Danger

AFP (Sep. 1, 2014) — Wedged between buses, lorries and cars, cycling in London isn't for the faint hearted. Nevertheless the number of people choosing to bike in the British capital has doubled over the past 15 years. Duration: 02:27 Video provided by AFP
Powered by NewsLook.com
Can You Train Your Brain To Eat Healthy?

Can You Train Your Brain To Eat Healthy?

Newsy (Sep. 1, 2014) — New research says if you condition yourself to eat healthy foods, eventually you'll crave them instead of junk food. Video provided by Newsy
Powered by NewsLook.com
We've Got Mites Living In Our Faces And So Do You

We've Got Mites Living In Our Faces And So Do You

Newsy (Aug. 30, 2014) — A new study suggests 100 percent of adult humans (those over 18 years of age) have Demodex mites living in their faces. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins