Featured Research

from universities, journals, and other organizations

Cell's Powerhouses Dismantled: Complete Inventory Of All Proteins In Mitochondria

Date:
October 16, 2009
Source:
VIB (the Flanders Institute for Biotechnology)
Summary:
All of life is founded on the interactions of millions of proteins. These are the building blocks for cells and form the molecular mechanisms of life. The problem is that proteins are extremely difficult to study, particularly because there are so many of them and they appear in all sizes and weights. Now, researchers have made a breakthrough in protein research -- making virtually the complete inventory of all the proteins in the mitochondria, the energy producers found in every cell.

All of life is founded on the interactions of millions of proteins. These are the building blocks for cells and form the molecular mechanisms of life. The problem is that proteins are extremely difficult to study, particularly because there are so many of them and they appear in all sizes and weights. Now, Kris Gevaert from VIB/Ghent University and colleagues from the universities of Freiburg and Bochum have achieved a breakthrough in protein research. Using yeast, they have succeeded in making virtually the complete inventory of all the proteins in the mitochondria, the energy producers found in every cell.

Related Articles


Their research findings are being published in the journal Cell.

During their research, the scientists encountered the Icp55 enzyme, which fulfills an important role in the stabilization of the proteins in the mitochondria. Until now, it was unclear just how the cell accomplished this. Icp55 turns out to be a molecular pair of scissors that snips off one of the ends of certain proteins, so that these proteins are transformed from an unstable to a stable form.

"This is a crucial step for fundamental research on proteins, the building blocks of life," says Kris Gevaert, VIB researcher at Ghent University. "It's the first time that such a precise protein determination of the mitochondria has been achieved. Our breakthrough was made possible by COFRADIC, a technology that enables us to analyze protein mixtures much more sensitively and accurately."

"We're now able to detect protein forms that were simply overlooked before," Kris Gevaert continues. "So we're receiving requests for scientific collaborations from all over the world."

COFRADIC is a technology developed by VIB/Ghent University researchers Joël Vandekerckhove and Kris Gevaert. With COFRADIC, the traditional conception of protein identification has been turned upside-down. Instead of first separating the intact proteins, the entire protein mixture is cut into small pieces (peptides) − which are more soluble and much easier to separate in order to conduct further analyses. Applying this approach to the samples provided by the German scientists revealed a new protein (Icp55) − which proved to be key in explaining protein stabilization in mitochondria, a mystery that has been unsolved up to now.


Story Source:

The above story is based on materials provided by VIB (the Flanders Institute for Biotechnology). Note: Materials may be edited for content and length.


Cite This Page:

VIB (the Flanders Institute for Biotechnology). "Cell's Powerhouses Dismantled: Complete Inventory Of All Proteins In Mitochondria." ScienceDaily. ScienceDaily, 16 October 2009. <www.sciencedaily.com/releases/2009/10/091015123602.htm>.
VIB (the Flanders Institute for Biotechnology). (2009, October 16). Cell's Powerhouses Dismantled: Complete Inventory Of All Proteins In Mitochondria. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2009/10/091015123602.htm
VIB (the Flanders Institute for Biotechnology). "Cell's Powerhouses Dismantled: Complete Inventory Of All Proteins In Mitochondria." ScienceDaily. www.sciencedaily.com/releases/2009/10/091015123602.htm (accessed October 25, 2014).

Share This



More Plants & Animals News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) — Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) — Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) — One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) — Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins