Featured Research

from universities, journals, and other organizations

Gamma Knife Treatment For Glioblastomas Shows Promising Results

Date:
November 3, 2009
Source:
University Hospitals Case Medical Center
Summary:
Researchers report promising results from a cutting-edge research study that treated the aggressive brain tumors glioblastoma multiforme using a novel type of imaging called MR spectroscopy coupled with high dose radiation in the form of Gamma Knife radiosurgery. Patients' survival rates increased by almost four months (3.7 months) compared with patients who were treated with traditional conventional radiotherapy alone.

Researchers from University Hospitals Case Medical Center report promising results from a cutting-edge research study that treated the aggressive brain tumors glioblastoma multiforme (GBM) using a novel type of imaging called MR spectroscopy coupled with high dose radiation in the form of Gamma Knife radiosurgery.

Patients' survival rates increased by almost four months (3.7 months) compared with patients who were treated with traditional conventional radiotherapy alone.

"The four month increase is quite significant as the median survival of patients treated with conventional radiotherapy alone is only one year," said Douglas B. Einstein, M.D., Ph.D., lead author of the study and Vice Chairman and Clinical Director of the Department of Radiation Oncology at University Hospitals Case Medical Center and Assistant Professor at Case Western Reserve University School of Medicine.

The results of this study were presented at the American Society for Radiation Oncology (ASTRO) meeting in Chicago on Nov. 2, 2009.

GBM is the most common and aggressive type of brain cancer, and is notorious for growing back within months of surgery. It is the type of cancer that the late Sen. Edward Kennedy battled.

Thirty-five patients were enrolled in this Phase II, five-year study. Patients underwent MR spectroscopy imaging to non-invasively identify regions of the GBM tumor that were more aggressive than other areas. These regions were then targeted with high-dose radiation from a Gamma Knife. Treatment was then followed by standard conventional radiotherapy.

The Gamma Knife is an instrument that allows physicians to perform radiosurgery, a non-invasive neurosurgical procedure that uses powerful doses of radiation to target and treat diseased brain tissue while leaving surrounding tissue intact. The state-of-the art technology allows physicians to operate on brain lesions often considered inoperable.

MR spectroscopy involves a specialized MR scan where peaks of metabolic compounds can be identified and quantitated within the MR image. These peaks include choline which is elevated in areas of the MR image that have a high cell turnover such as an active brain tumor and NAA found in neuronal tissue and used to separate normal neuronal cells from the glioma brain tumor cells.

Given the positive finding from this study, a multi-center Phase III randomized trial is being designed, said Dr. Einstein.


Story Source:

The above story is based on materials provided by University Hospitals Case Medical Center. Note: Materials may be edited for content and length.


Cite This Page:

University Hospitals Case Medical Center. "Gamma Knife Treatment For Glioblastomas Shows Promising Results." ScienceDaily. ScienceDaily, 3 November 2009. <www.sciencedaily.com/releases/2009/11/091102171223.htm>.
University Hospitals Case Medical Center. (2009, November 3). Gamma Knife Treatment For Glioblastomas Shows Promising Results. ScienceDaily. Retrieved April 17, 2014 from www.sciencedaily.com/releases/2009/11/091102171223.htm
University Hospitals Case Medical Center. "Gamma Knife Treatment For Glioblastomas Shows Promising Results." ScienceDaily. www.sciencedaily.com/releases/2009/11/091102171223.htm (accessed April 17, 2014).

Share This



More Health & Medicine News

Thursday, April 17, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Is Apathy A Sign Of A Shrinking Brain?

Is Apathy A Sign Of A Shrinking Brain?

Newsy (Apr. 17, 2014) A recent study links apathetic feelings to a smaller brain. Researchers say the results indicate a need for apathy screening for at-risk seniors. Video provided by Newsy
Powered by NewsLook.com
Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Thousands Of Vials Of SARS Virus Go Missing

Thousands Of Vials Of SARS Virus Go Missing

Newsy (Apr. 16, 2014) A research institute in Paris somehow misplaced more than 2,000 vials of the deadly SARS virus. Video provided by Newsy
Powered by NewsLook.com
Formerly Conjoined Twins Released From Dallas Hospital

Formerly Conjoined Twins Released From Dallas Hospital

Newsy (Apr. 16, 2014) Conjoined twins Emmett and Owen Ezell were separated by doctors in August. Now, nearly nine months later, they're being released from the hospital. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins