Featured Research

from universities, journals, and other organizations

Metabolomics uncovers key indicators of nonalcoholic fatty liver disease

Date:
November 24, 2009
Source:
Wiley-Blackwell
Summary:
A recent metabolomics study found that impaired peroxisomal oxidation of polyunsaturated fatty acids is associated with the progression of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH). The study also found significantly higher plasma monounsaturated fatty acids in the blood of patients with NAFL and NASH.

A recent metabolomics study by researchers from Virginia Commonwealth University Medical Center in Richmond found that impaired peroxisomal oxidation of polyunsaturated fatty acids (PUFA) is associated with the progression of nonalcoholic fatty liver (NAFL) to nonalcoholic steatohepatitis (NASH). The study also found significantly higher plasma monounsaturated fatty acids in the blood of patients with NAFL and NASH.

Related Articles


Full findings appear in the December issue of Hepatology, a journal published by Wiley-Blackwell on behalf of the American Association for the Study of Liver Diseases.

Nonalcoholic fatty liver disease (NAFLD) affects a third of the U.S. adult population, with many cases found in obese individuals. NAFLD ranges from NAFL, a benign condition where fat accumulates in the liver of people who drink little or no alcohol, to a more serious state known as NASH where inflammation or scarring of the liver occurs and which can progress to liver failure.

Study participants included 50 in a lean normal control, 25 subjects with NAFL and 50 patients with NASH. Researchers classified the NAFL group by a diagnosis of fatty liver with the presence of accumulated liver fat of at least grade 1 severity according to the NASH Clinical Research Network criteria. The NASH group included those with at least a grade 1 severity in accumulated liver fat, inflammation and cytologic ballooning of at least grade 1 severity in each. The nonalcoholic nature of the disease was established by clinical assessment that the alcohol consumption was less than 20 gm/day for women and 30 gm/day for men. Lean normal controls were identified by a body mass index between 18-25 kg/m2, absence of symptoms or signs of disease, normal liver enzymes and hepatic sonogram.

The research team, headed by Arun Sanyal, M.B.B.S., M.D., used mass spectrometry (a technique that determines the basic composition of a sample) to analyze blood lipids and metabolites of the NAFL and NASH subjects comparing them with the control group. Data revealed that the development of NAFL is accompanied by increased lipogenesis, ∆ 9 desaturase and LOX activity. "Our study provides the most comprehensive picture of lipid metabolism in NAFLD to date," said Dr. Sanyal.

Results indicate that when the condition of the liver progresses to NASH the lipogenic activity levels off or declines modestly while the LOX activity increases. Simultaneously, there is impaired peroxisomal PUFA metabolism and increase in levels of products of non-enzymatic oxidation of arachidonic acid. "Further study of the role specific metabolic pathways play in the establishment and progression of NASH are needed," concluded Dr. Sanyal. "Our findings serve as a basis for future research of NAFLD."


Story Source:

The above story is based on materials provided by Wiley-Blackwell. Note: Materials may be edited for content and length.


Journal Reference:

  1. Puneet Puri, Michelle M. Wiest, Onpan Cheung, Faridoddin Mirshahi, Carol Sargeant, Hae-Ki Min, Melissa J. Contos, Richard K.sterling, Michael Fuchs, Huiping Zhou, Steven M. Watkins, and Arun J. Sanyal. The plasma lipidomic signature of nonalcoholic steatohepatitis. Hepatology, 2009; 50 (6): 1827 DOI: 10.1002/hep.23229

Cite This Page:

Wiley-Blackwell. "Metabolomics uncovers key indicators of nonalcoholic fatty liver disease." ScienceDaily. ScienceDaily, 24 November 2009. <www.sciencedaily.com/releases/2009/11/091124082759.htm>.
Wiley-Blackwell. (2009, November 24). Metabolomics uncovers key indicators of nonalcoholic fatty liver disease. ScienceDaily. Retrieved March 31, 2015 from www.sciencedaily.com/releases/2009/11/091124082759.htm
Wiley-Blackwell. "Metabolomics uncovers key indicators of nonalcoholic fatty liver disease." ScienceDaily. www.sciencedaily.com/releases/2009/11/091124082759.htm (accessed March 31, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, March 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Solitair Device Aims to Takes Guesswork out of Sun Safety

Solitair Device Aims to Takes Guesswork out of Sun Safety

Reuters - Innovations Video Online (Mar. 31, 2015) — The Solitair device aims to take the confusion out of how much sunlight we should expose our skin to. Small enough to be worn as a tie or hair clip, it monitors the user&apos;s sun exposure by taking into account their skin pigment, location and schedule. Matthew Stock reports. Video provided by Reuters
Powered by NewsLook.com
Soda, Salt and Sugar: The Next Generation of Taxes

Soda, Salt and Sugar: The Next Generation of Taxes

Washington Post (Mar. 30, 2015) — Denisa Livingston, a health advocate for the Dinι Community Advocacy Alliance, and the Post&apos;s Abby Phillip discuss efforts around the country to make unhealthy food choices hurt your wallet as much as your waistline. Video provided by Washington Post
Powered by NewsLook.com
UnitedHealth Buys Catamaran

UnitedHealth Buys Catamaran

Reuters - Business Video Online (Mar. 30, 2015) — The $12.8 billion merger will combine the U.S.&apos; third and fourth largest pharmacy benefit managers. Analysts say smaller PBMs could also merge. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com
S. Leone in New Anti-Ebola Lockdown

S. Leone in New Anti-Ebola Lockdown

AFP (Mar. 28, 2015) — Sierra Leone imposed a three-day nationwide lockdown Friday for the second time in six months in a bid to prevent a resurgence of the deadly Ebola virus. Duration: 01:17 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins