Featured Research

from universities, journals, and other organizations

Last ancestor humans shared with worms had sophisticated brain, microRNAs show

Date:
February 2, 2010
Source:
European Molecular Biology Laboratory
Summary:
The last ancestor we shared with worms, which roamed the seas around 600 million years ago, may already have had a sophisticated brain. Fossils cannot give us this information, but scientists have obtained it by studying small molecules called microRNAs.

The marine ragworm Platynereis dumerilii.
Credit: Udo Ringeisen/EMBL

The last ancestor we shared with worms, which roamed the seas around 600 million years ago, may already have had a sophisticated brain that released hormones into the blood and was connected to various sensory organs. The evidence comes not from a newly found fossil but from the study of microRNAs -- small RNA molecules that regulate gene expression -- in animals alive today.

Scientists at the European Molecular Biology Laboratory (EMBL) in Heidelberg, Germany, have discovered that these molecules are found in the exact same tissues in animals as diverse as sea anemones, worms, and humans, hinting at an early origin of these tissues in animal evolution. Their findings, published in Nature, also open new avenues for studying the current functions of specific microRNAs.

Animals from different branches of the evolutionary tree -- different lineages -- possess specific microRNAs that evolved only in their lineage. But they also have microRNAs in common: ones which they inherited from their last common ancestor, and which have been conserved throughout animal evolution.

The EMBL scientists looked at the marine annelid Platynereis dumerilii, which is thought to have changed little over the past 600 million years. They visualised where these conserved microRNAs are expressed, and compared Platynereis with other animals. They found that in Platynereis these microRNAs are highly specific for certain tissues and cell types and, what is more, discovered that tissue specificity was conserved over hundreds of millions of years of evolutionary time.

The scientists reasoned that if an ancient microRNA is found in a specific part of the brain in one species and in a very similar location in another species, then this brain part probably already existed in the last common ancestor of those species. Thus, they were able to glean a glimpse of the past, an idea of some of the traits of the last common ancestor of worms and humans.

"By looking at where in the body different microRNAs evolved, we can build a picture of ancestors for which we have no fossils, and uncover traits that fossils simply cannot show us," says Detlev Arendt, who headed the study: "But uncovering where these ancient microRNAs are expressed in animals from different branches of the evolutionary tree has so far been very challenging."

"We found that annelids such as Platynereis and vertebrates such as ourselves share some microRNAs that are specific to the parts of the central nervous system that secrete hormones into the blood, and others that are restricted to other parts of the central or peripheral nervous systems, or to gut or musculature," explains Foteini Christodoulou, who carried out most of the experimental work. "This means that our last common ancestor already had all these structures."

Knowing where microRNAs were expressed in our ancestors could also help scientists understand the role of specific microRNA molecules today, as it gives them a clue of where to look.

"If a certain microRNA is known to have evolved in the gut, for instance, it is likely to still carry out a function there," explains EMBL scientist Peer Bork, who also contributed to the study. Next, Arendt and colleagues would like to investigate the exact function of each of these conserved microRNAs -- what genes they regulated, and what processes those genes were involved in -- in an attempt to determine what their role might have been in the ancient past.


Story Source:

The above story is based on materials provided by European Molecular Biology Laboratory. Note: Materials may be edited for content and length.


Journal Reference:

  1. Christodoulou, F., Raible, F., Tomer, R., Simakov, O., Trachana, K., Klaus, S., Snyman, H., Hannon, G.J., Bork, P. & Arendt, D. Ancient animal microRNAs and the evolution of tissue identity. Nature, 2010; DOI: 10.1038/nature08744

Cite This Page:

European Molecular Biology Laboratory. "Last ancestor humans shared with worms had sophisticated brain, microRNAs show." ScienceDaily. ScienceDaily, 2 February 2010. <www.sciencedaily.com/releases/2010/02/100201101905.htm>.
European Molecular Biology Laboratory. (2010, February 2). Last ancestor humans shared with worms had sophisticated brain, microRNAs show. ScienceDaily. Retrieved October 21, 2014 from www.sciencedaily.com/releases/2010/02/100201101905.htm
European Molecular Biology Laboratory. "Last ancestor humans shared with worms had sophisticated brain, microRNAs show." ScienceDaily. www.sciencedaily.com/releases/2010/02/100201101905.htm (accessed October 21, 2014).

Share This



More Fossils & Ruins News

Tuesday, October 21, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Turns Out Jack The Ripper's True Identity Is Still Unknown

Turns Out Jack The Ripper's True Identity Is Still Unknown

Newsy (Oct. 20, 2014) After testing DNA from a shawl found near one of Jack the Ripper's victims, a scientist said he'd identified the killer. New reports refute the claim. Video provided by Newsy
Powered by NewsLook.com
Fish Fossil Shows First-Ever Sex Was Done Side By Side

Fish Fossil Shows First-Ever Sex Was Done Side By Side

Newsy (Oct. 19, 2014) A 380-million-year-old fish may be the first creature to have copulative sex - and it was side by side with arms linked, like square dancers. Video provided by Newsy
Powered by NewsLook.com
As Sweden Hunts For Sub, "Cold War" Comparisons Flourish

As Sweden Hunts For Sub, "Cold War" Comparisons Flourish

Newsy (Oct. 19, 2014) With Sweden on the look-out for a suspected Russian sub, a lot of people are talking about the Cold War, but is it an apt comparison? Video provided by Newsy
Powered by NewsLook.com
So, Kangaroos Didn't Always Hop

So, Kangaroos Didn't Always Hop

Newsy (Oct. 16, 2014) Researchers believe an extinct kangaroo species weighed 500 pounds or more and couldn't hop. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins