Featured Research

from universities, journals, and other organizations

Virology: New insight into Chikungunya virus infection from nonhuman primates

Date:
February 22, 2010
Source:
Journal of Clinical Investigation
Summary:
Researchers have successfully modeled CHIKV infection in cynomolgus macaques. Specifically, CHIKV infection in cynomolgus macaques was found to recapitulate the viral, clinical, and pathological features observed in CHIKV infected humans.

Chikungunya virus (CHIKV) is transmitted to humans from mosquitos. It causes a severely debilitating disease characterized by fever, rash, and pain in muscles and joints. Chikungunya disease is emerging as a considerable health problem in Africa, Asia, and the islands of the Indian Ocean. CHIKV infection is currently modeled in mice, but mouse models do not accurately mimic the disease seen in humans and are not useful for the development of vaccines and immune cell-based therapeutics.

Related Articles


Now, Pierre Roques and colleagues, at the Commissariat l'Energie Atomique, France, have successfully modeled CHIKV infection in cynomolgus macaques. Specifically, CHIKV infection in cynomolgus macaques was found to recapitulate the viral, clinical, and pathological features observed in CHIKV infected humans.

The research appears in the Journal of Clinical Investigation.

Importantly, using this model of CHIKV infection, the authors determined that CHIKV infection persisted long term in joints, muscles, lymphoid organs, and liver, and that during this long-term infection the virus resided in immune cells known as macrophages.

The authors hope this model of CHIKV infection will be useful to develop new therapeutic and/or prophylactic strategies, a sentiment echoed by Stephen Higgs and Sarah Ziegler, at the University of Texas Medical Branch, Galveston, in an accompanying commentary.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal References:

  1. Karine Labadie, Thibaut Larcher, Christophe Joubert, Abdelkrim Mannioui, Benoit Delache, Patricia Brochard, Lydie Guigand, Laurence Dubreil, Pierre Lebon, Bernard Verrier, Xavier De Lamballerie, Andreas Suhrbier, Yan Cherel, Roger Le Grand, and Pierre Roques. Chikungunya disease in nonhuman primates involves long-term viral persistence in macrophages. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI40104
  2. Stephen Higgs and Sarah A. Ziegler. A nonhuman primate model of chikungunya disease. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI42392

Cite This Page:

Journal of Clinical Investigation. "Virology: New insight into Chikungunya virus infection from nonhuman primates." ScienceDaily. ScienceDaily, 22 February 2010. <www.sciencedaily.com/releases/2010/02/100222213002.htm>.
Journal of Clinical Investigation. (2010, February 22). Virology: New insight into Chikungunya virus infection from nonhuman primates. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2010/02/100222213002.htm
Journal of Clinical Investigation. "Virology: New insight into Chikungunya virus infection from nonhuman primates." ScienceDaily. www.sciencedaily.com/releases/2010/02/100222213002.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Suicide Rates Up For Young Women In U.S.

Suicide Rates Up For Young Women In U.S.

Newsy (Mar. 6, 2015) According to a report from the CDC, suicide rates among young women increased from 1994 to 2012 while rates among young men have decreased. Video provided by Newsy
Powered by NewsLook.com
Bupa Eyes India Healthcare Opportunities

Bupa Eyes India Healthcare Opportunities

Reuters - Business Video Online (Mar. 5, 2015) Bupa is hoping to expand in India&apos;s fast-growing health insurance market, once a rule change on foreign investment is implemented. The British private healthcare group&apos;s CEO tells Grace Pascoe why it&apos;s so keen on the new opportunity. Video provided by Reuters
Powered by NewsLook.com
Liberia Releases Last Ebola Patient, But Threat Remains

Liberia Releases Last Ebola Patient, But Threat Remains

Newsy (Mar. 5, 2015) Liberia&apos;s last Ebola patient has been released, and the country hasn&apos;t recorded a new case in a week. However, fears of another outbreak still exist. Video provided by Newsy
Powered by NewsLook.com
Doctor in Your Pocket Is Getting Smarter

Doctor in Your Pocket Is Getting Smarter

Reuters - Business Video Online (Mar. 5, 2015) Mobile apps are turning smartphones into a personal doctors, with users able to measure heart rate, blood pressure and even blood sugar. But will it change our behaviour? Ivor Bennett reports from the Mobile World Congress in Barcelona. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins