Featured Research

from universities, journals, and other organizations

Scientific breakthrough in combating HIV-1 virus

Date:
April 9, 2010
Source:
Institut de recherches cliniques de Montreal
Summary:
Scientists have made major breakthrough in understanding how the Vpu protein of HIV-1 interferes with the antiviral activity of Tetherin, a novel effector of innate immunity, and contributes to the spread of HIV-1 in humans.

A discovery by Dr. Éric A. Cohen's team at the Institut de recherches cliniques de Montréal, could potentially lead to the development of new strategies to combat the human immunodeficiency virus (HIV-1), the causal agent of acquired immunodeficiency syndrome (AIDS).

Related Articles


In their article published in the open-access journal PLoS Pathogens, Dr. Cohen's team explains how the Vpu viral protein prevents the expression of Tetherin, a host factor inhibiting HIV-1 release, on the surface of infected cells.

Thus, if researchers manage to develop small molecules that prevent Vpu binding to Tetherin, this would restore one of the natural defence mechanisms that prevent the production, transmission and spread of HIV-1.

The study by Dr. Cohen's team allows a better understanding of the strategy used by HIV-1 to facilitate its transmission and its spread in humans. "Tetherin is a cellular protein that captures viruses forming at the surface of infected cells, thereby preventing viral transmission and spread. This antiviral protein, whose production is triggered by interferon, is an effector of the innate immune response against viral infections. However, viruses, and especially HIV-1, have evolved and developed mechanisms that antagonize this restriction factor. In fact, we have discovered how the Vpu protein neutralizes Tetherin, and as such stimulates HIV-1 production," stated Dr. Éric A. Cohen.

By directly binding Tetherin, Vpu adversely affects the transport of the restriction factor to the cell surface, which is the site of its antiviral activity. Tetherin is therefore stored within the cell, thus preventing it from playing its role as a "barrier" against virus transmission. "Simian immunodeficiency viruses, considered to be precursors of HIV-1, are unable to antagonize human Tetherin. It would appear that the emergence of HIV-1 strains encoding Vpu proteins with the ability to perturb the intracellular transport of human Tetherin, could have contributed to the pandemic spread of certain groups of HIV-1," specified Mathieu Dubé, doctorate candidate at the IRCM's Human Retrovirology Research Unit, and the first author of the article.

"We need to better understand how HIV is transmitted in order to develop new HIV prevention and treatment strategies," said Dr. Marc Ouellette, Scientific Director of the Canadian Institutes of Health Research's Institute of Infection and Immunity. "This is a very important finding by Dr. Cohen's research team and another example of the superb research being done in Canada in this area."

This project was supported by the Canadian Institutes of Health Research (CIHR), the Canada Research Chair Program and the Canadian Foundation for Innovation


Story Source:

The above story is based on materials provided by Institut de recherches cliniques de Montreal. Note: Materials may be edited for content and length.


Journal Reference:

  1. Mathieu Dubé, Bibhuti Bhusan Roy, Pierre Guiot-Guillain, Julie Binette, Johanne Mercier, Antoine Chiasson, Éric A. Cohen. Antagonism of Tetherin Restriction of HIV-1 Release by Vpu Involves Binding and Sequestration of the Restriction Factor in a Perinuclear Compartment. PLoS Pathogens, 6(4): e1000856 DOI: 10.1371/journal.ppat.1000856

Cite This Page:

Institut de recherches cliniques de Montreal. "Scientific breakthrough in combating HIV-1 virus." ScienceDaily. ScienceDaily, 9 April 2010. <www.sciencedaily.com/releases/2010/04/100408171510.htm>.
Institut de recherches cliniques de Montreal. (2010, April 9). Scientific breakthrough in combating HIV-1 virus. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2010/04/100408171510.htm
Institut de recherches cliniques de Montreal. "Scientific breakthrough in combating HIV-1 virus." ScienceDaily. www.sciencedaily.com/releases/2010/04/100408171510.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) — A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins