Featured Research

from universities, journals, and other organizations

Genes and pesticide exposure interact to increase men's risk for Parkinson's disease

Date:
June 14, 2010
Source:
JAMA and Archives Journals
Summary:
Genetic mutations and workplace exposure to some insecticides together appear to be associated with an increased risk for Parkinson's disease among men, according to a new study.

Genetic mutations and workplace exposure to some insecticides together appear to be associated with an increased risk for Parkinson's disease among men, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals.

Related Articles


"In most cases, the etiology of Parkinson's disease is likely to be multifactorial, and environmental factors as well as their interaction with susceptibility genes are considered to contribute to the disease," the authors write as background information in the article. Humans exposed to certain pesticides, including organochlorines such as DDT, have been shown to develop Parkinson's disease through damage to neurons that produce the neurotransmitter dopamine.

"If environmental chemicals can increase Parkinson's disease risk, host factors that contribute to variability in their uptake, metabolism and distribution in the body may modulate individual risk," the authors write. "Genetic polymorphisms of xenobiotic [compounds not naturally found in the body] metabolizing enzymes may act as susceptibility factors." The gene ABCB1 may encode the production of compounds essential to this process.

Fabien Dutheil, Ph.D., of Universitι Paris Descartes, Assistance-Publique Hτpitaux de Paris, and colleagues studied 207 individuals with Parkinson's disease and 482 matched controls. Participants were assessed to detect two known ABCB1 polymorphisms and classified as never users, users for gardening and professional users of pesticides. For professional users, detailed information on lifelong pesticide use was gathered.

Overall, ABCB1 polymorphisms were not associated with Parkinson's disease risk. However, among 101 men with Parkinson's disease and 234 matched controls, the relationship between organochlorine insecticide exposure and Parkinson's disease was approximately 3.5 times stronger in men who carried two variant alleles (gene copies) compared with those who were not carriers.

"Based on a biological hypothesis, we show that organochlorine insecticides may interact with ABCB1 in determining the risk of Parkinson's disease," the authors conclude. "These findings support the hypothesis of gene x pesticide interactions in Parkinson's disease."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fabien Dutheil; Philippe Beaune; Christophe Tzourio; Marie-Anne Loriot; Alexis Elbaz. Interaction Between ABCB1 and Professional Exposure to Organochlorine Insecticides in Parkinson Disease. Arch Neurol, 2010; 67 (6): 739-745 [link]

Cite This Page:

JAMA and Archives Journals. "Genes and pesticide exposure interact to increase men's risk for Parkinson's disease." ScienceDaily. ScienceDaily, 14 June 2010. <www.sciencedaily.com/releases/2010/06/100614161359.htm>.
JAMA and Archives Journals. (2010, June 14). Genes and pesticide exposure interact to increase men's risk for Parkinson's disease. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2010/06/100614161359.htm
JAMA and Archives Journals. "Genes and pesticide exposure interact to increase men's risk for Parkinson's disease." ScienceDaily. www.sciencedaily.com/releases/2010/06/100614161359.htm (accessed December 19, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Friday, December 19, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

The Best Tips to Curb Holiday Carbs

The Best Tips to Curb Holiday Carbs

Buzz60 (Dec. 19, 2014) — It's hard to resist those delicious but fattening carbs we all crave during the winter months, but there are some ways to stay satisfied without consuming the extra calories. Vanessa Freeman (@VanessaFreeTV) has the details. Video provided by Buzz60
Powered by NewsLook.com
Sierra Leone Bikers Spread the Message to Fight Ebola

Sierra Leone Bikers Spread the Message to Fight Ebola

AFP (Dec. 19, 2014) — More than 100 motorcyclists hit the road to spread awareness messages about Ebola. Nearly 7,000 people have now died from the virus, almost all of them in west Africa, according to the World Health Organization. Video provided by AFP
Powered by NewsLook.com
Researchers Test Colombian Village With High Alzheimer's Rates

Researchers Test Colombian Village With High Alzheimer's Rates

AFP (Dec. 19, 2014) — In Yarumal, a village in N. Colombia, Alzheimer's has ravaged a disproportionately large number of families. A genetic "curse" that may pave the way for research on how to treat the disease that claims a new victim every four seconds. Duration: 02:42 Video provided by AFP
Powered by NewsLook.com
Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Double-Amputee Becomes First To Move Two Prosthetic Arms With His Mind

Buzz60 (Dec. 19, 2014) — A double-amputee makes history by becoming the first person to wear and operate two prosthetic arms using only his mind. Jen Markham has the story. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins