Featured Research

from universities, journals, and other organizations

Genes and pesticide exposure interact to increase men's risk for Parkinson's disease

Date:
June 14, 2010
Source:
JAMA and Archives Journals
Summary:
Genetic mutations and workplace exposure to some insecticides together appear to be associated with an increased risk for Parkinson's disease among men, according to a new study.

Genetic mutations and workplace exposure to some insecticides together appear to be associated with an increased risk for Parkinson's disease among men, according to a report in the June issue of Archives of Neurology, one of the JAMA/Archives journals.

"In most cases, the etiology of Parkinson's disease is likely to be multifactorial, and environmental factors as well as their interaction with susceptibility genes are considered to contribute to the disease," the authors write as background information in the article. Humans exposed to certain pesticides, including organochlorines such as DDT, have been shown to develop Parkinson's disease through damage to neurons that produce the neurotransmitter dopamine.

"If environmental chemicals can increase Parkinson's disease risk, host factors that contribute to variability in their uptake, metabolism and distribution in the body may modulate individual risk," the authors write. "Genetic polymorphisms of xenobiotic [compounds not naturally found in the body] metabolizing enzymes may act as susceptibility factors." The gene ABCB1 may encode the production of compounds essential to this process.

Fabien Dutheil, Ph.D., of Universitι Paris Descartes, Assistance-Publique Hτpitaux de Paris, and colleagues studied 207 individuals with Parkinson's disease and 482 matched controls. Participants were assessed to detect two known ABCB1 polymorphisms and classified as never users, users for gardening and professional users of pesticides. For professional users, detailed information on lifelong pesticide use was gathered.

Overall, ABCB1 polymorphisms were not associated with Parkinson's disease risk. However, among 101 men with Parkinson's disease and 234 matched controls, the relationship between organochlorine insecticide exposure and Parkinson's disease was approximately 3.5 times stronger in men who carried two variant alleles (gene copies) compared with those who were not carriers.

"Based on a biological hypothesis, we show that organochlorine insecticides may interact with ABCB1 in determining the risk of Parkinson's disease," the authors conclude. "These findings support the hypothesis of gene x pesticide interactions in Parkinson's disease."


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. Fabien Dutheil; Philippe Beaune; Christophe Tzourio; Marie-Anne Loriot; Alexis Elbaz. Interaction Between ABCB1 and Professional Exposure to Organochlorine Insecticides in Parkinson Disease. Arch Neurol, 2010; 67 (6): 739-745 [link]

Cite This Page:

JAMA and Archives Journals. "Genes and pesticide exposure interact to increase men's risk for Parkinson's disease." ScienceDaily. ScienceDaily, 14 June 2010. <www.sciencedaily.com/releases/2010/06/100614161359.htm>.
JAMA and Archives Journals. (2010, June 14). Genes and pesticide exposure interact to increase men's risk for Parkinson's disease. ScienceDaily. Retrieved October 1, 2014 from www.sciencedaily.com/releases/2010/06/100614161359.htm
JAMA and Archives Journals. "Genes and pesticide exposure interact to increase men's risk for Parkinson's disease." ScienceDaily. www.sciencedaily.com/releases/2010/06/100614161359.htm (accessed October 1, 2014).

Share This



More Health & Medicine News

Wednesday, October 1, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Some Positive Ebola News: Outbreak 'Contained' In Nigeria

Newsy (Sep. 30, 2014) — The CDC says a new case of Ebola has not been reported in Nigeria for more than 21 days, leading to hopes the outbreak might be nearing its end. Video provided by Newsy
Powered by NewsLook.com
UN Ebola Mission Head: Immediate Action Is Crucial

UN Ebola Mission Head: Immediate Action Is Crucial

AFP (Sep. 30, 2014) — The newly appointed head of the United Nations Mission for Ebola Emergency Response (UNMEER), Anthony Banbury, outlines operations to tackle the virus. Duration: 00:39 Video provided by AFP
Powered by NewsLook.com
CDC Confirms First Case of Ebola in US

CDC Confirms First Case of Ebola in US

AP (Sep. 30, 2014) — The CDC has confirmed the first diagnosed case of Ebola in the United States. The patient is being treated at a Dallas hospital after traveling earlier this month from Liberia. (Sept. 30) Video provided by AP
Powered by NewsLook.com
New Breast Cancer Drug Extends Lives In Clinical Trial

New Breast Cancer Drug Extends Lives In Clinical Trial

Newsy (Sep. 30, 2014) — In a clinical trial, breast cancer patients lived an average of 15 months longer when they received new drug Perjeta along with Herceptin. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins