Featured Research

from universities, journals, and other organizations

New protein critical for mitochondria discovered

Date:
November 3, 2010
Source:
Institute for Research in Biomedicine-IRB
Summary:
Researchers in Spain have discovered a new protein in the fruit fly that is crucial for mitochondria. The removal of SLIMP in these flies leads to aberrant mitochondria and loss of metabolic capacity, thus causing death.

Researchers in Spain have discovered a new protein in the fly Drosophila melanogaster (fruit fly) that is crucial for mitochondria. The removal of SLIMP in these flies leads to aberrant mitochondria and loss of metabolic capacity, thus causing death.

The study -- whose first author is Tanit Guitart, a PhD student in the lab of Lluís Ribas de Pouplana, ICREA professor at the Institute for Research in Biomedicine (IRB Barcelona) -- appears in the December issue of the Journal of Biological Chemistry, which is already available online.

Result of animal evolution

The SLIMP protein derives from a seryl-tRNA synthetase, universal enzymes that are crucial for the synthesis of new proteins. However, SLIMP has lost its original function and performs a different biological role, which remains to be determined. The researchers studied its possible implication in the regulation of mitochondrial division and the interaction with nucleic acids (DNA, RNA).

SLIMP evolved by duplication of the seryl-tRNA synthetase about 540 million years ago, at the beginning of the Cambrian, before the appearance of the starfish and sea urchins family. SLIMP is not present in vertebrates, and it is possible that another protein has taken over its function.

"If this were the case, we could look for the protein equivalent in vertebrates, determine its function and focus on these organisms. Here we have work for the next ten years," says Ribas.

This study was performed in collaboration with researchers in the groups devoted to Heterogenic and Multigenic Diseases and Chromatin structure and function, both at IRB Barcelona.


Story Source:

The above story is based on materials provided by Institute for Research in Biomedicine-IRB. Note: Materials may be edited for content and length.


Journal Reference:

  1. T. Guitart, T. Leon Bernardo, J. Segales, T. Stratmann, J. Bernues, L. Ribas de Pouplana. A new aminoacyl-tRNA synthetase-like protein in insecta with an essential mitochondrial function. Journal of Biological Chemistry, 2010; DOI: 10.1074/jbc.M110.167486

Cite This Page:

Institute for Research in Biomedicine-IRB. "New protein critical for mitochondria discovered." ScienceDaily. ScienceDaily, 3 November 2010. <www.sciencedaily.com/releases/2010/11/101102124422.htm>.
Institute for Research in Biomedicine-IRB. (2010, November 3). New protein critical for mitochondria discovered. ScienceDaily. Retrieved April 23, 2014 from www.sciencedaily.com/releases/2010/11/101102124422.htm
Institute for Research in Biomedicine-IRB. "New protein critical for mitochondria discovered." ScienceDaily. www.sciencedaily.com/releases/2010/11/101102124422.htm (accessed April 23, 2014).

Share This



More Plants & Animals News

Wednesday, April 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Monkeys Are Better At Math Than We Thought, Study Shows

Monkeys Are Better At Math Than We Thought, Study Shows

Newsy (Apr. 23, 2014) — A Harvard University study suggests monkeys can use symbols to perform basic math calculations. Video provided by Newsy
Powered by NewsLook.com
Raw: Leopard Bites Man in India

Raw: Leopard Bites Man in India

AP (Apr. 22, 2014) — A leopard caused panic in the city of Chandrapur on Monday when it sprung from the roof of a house and charged at rescue workers. (April 22) Video provided by AP
Powered by NewsLook.com
Iowa College Finds Beauty in Bulldogs

Iowa College Finds Beauty in Bulldogs

AP (Apr. 22, 2014) — Drake University hosts 35th annual Beautiful Bulldog Contest. (April 21) Video provided by AP
Powered by NewsLook.com
805-Pound Shark Caught Off The Coast Of Florida

805-Pound Shark Caught Off The Coast Of Florida

Newsy (Apr. 22, 2014) — One Florida fisherman caught a 805-pound shark off the coast of Florida earlier this month. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins