Featured Research

from universities, journals, and other organizations

Sweet discovery raises hope for treating Ebola, Lassa, Marburg and other fast-acting viruses

Date:
November 4, 2010
Source:
Federation of American Societies for Experimental Biology
Summary:
When a team of European researchers sought to discover how a class of antiviral drugs worked, they looked in an unlikely place: the sugar dish. A new research report suggests that a purified and modified form of a simple sugar chain may stop fast-acting and deadly viruses, such as Ebola, Lassa, or Marburg viruses, in their tracks.

When a team of European researchers sought to discover how a class of antiviral drugs worked, they looked in an unlikely place: the sugar dish. A new research report appearing in the Journal of Leukocyte Biology suggests that a purified and modified form of a simple sugar chain may stop fast-acting and deadly viruses, such as Ebola, Lassa, or Marburg viruses, in their tracks.

Related Articles


This compound, called chlorite-oxidized oxyamylose or COAM, could be a very attractive therapeutic option because not only did this compound enhance the early-stage immune defenses in mice, but because of sugar's abundance, it is derived from easily obtainable sources.

"We modified and purified a safe drug from natural sources and discovered how it can protect against deadly virus infections," said Ghislain Opdenakker, M.D., a researcher involved in the study from the Laboratory of Immunobiology at the Rega Institute for Medical Research and the University of Leuven in Belgium.

To make this discovery, researchers infected mice with a virus that kills in less than a week. When one group of these infected mice was treated with an unpurified version of the compound, about half of the infected mice were protected from the effects of the virus. Researchers then purified the compound and treated another group of infected mice. In that group, more than 90 percent survived the deadly infection. These results suggest that the purified compound almost completely blocked the killer virus by speeding the response of the body's fast-acting immune cells, called white blood cells or leukocytes, at the early stage of infection.

"This is an exciting discovery because it offers hope that we will finally be able to really do something about some of the world's deadliest viruses -- rapidly mobilizing antiviral immune cells is critical in the race between these killer viruses and the host," said John Wherry, Ph.D., Deputy Editor of the Journal of Leukocyte Biology. "The fact that this compound comes from something as abundant as sugar just sweetens the findings."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Li, S. Starckx, E. Martens, C. Dillen, N. Lamerant-Fayel, N. Berghmans, M. Gouwy, M. van Pel, H. Heremans, C. Kieda, W. E. Fibbe, A. Billiau, J. Van Damme, G. Opdenakker. Myeloid cells are tunable by a polyanionic polysaccharide derivative and co-determine host rescue from lethal virus infection. Journal of Leukocyte Biology, 2010; 88 (5): 1017 DOI: 10.1189/jlb.1109724

Cite This Page:

Federation of American Societies for Experimental Biology. "Sweet discovery raises hope for treating Ebola, Lassa, Marburg and other fast-acting viruses." ScienceDaily. ScienceDaily, 4 November 2010. <www.sciencedaily.com/releases/2010/11/101103111202.htm>.
Federation of American Societies for Experimental Biology. (2010, November 4). Sweet discovery raises hope for treating Ebola, Lassa, Marburg and other fast-acting viruses. ScienceDaily. Retrieved March 6, 2015 from www.sciencedaily.com/releases/2010/11/101103111202.htm
Federation of American Societies for Experimental Biology. "Sweet discovery raises hope for treating Ebola, Lassa, Marburg and other fast-acting viruses." ScienceDaily. www.sciencedaily.com/releases/2010/11/101103111202.htm (accessed March 6, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Friday, March 6, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Giant Panda Goes Walkabout in Southwest China

Giant Panda Goes Walkabout in Southwest China

AFP (Mar. 6, 2015) — A giant panda goes walkabout alone at night in southwest China. Duration: 00:37 Video provided by AFP
Powered by NewsLook.com
Nesting Bald Eagle Covered in Snow Up to Its Neck

Nesting Bald Eagle Covered in Snow Up to Its Neck

Buzz60 (Mar. 6, 2015) — The Pennsylvania State Game Commission captured amazing shots of a nesting bald eagle who stayed on its nest during a snowstorm, even when the snow piled all the way up to its neck. Jen Markham (@jenmarkham) has the story. Video provided by Buzz60
Powered by NewsLook.com
'Extinct' Bird Isn't Extinct At All, Scientists Find

'Extinct' Bird Isn't Extinct At All, Scientists Find

Buzz60 (Mar. 6, 2015) — Scientists rediscover a bird thought to be extinct, so we may be able to cross it off the "Gone For Good" list. Sean Dowling (@seandowlingtv) has more details. Video provided by Buzz60
Powered by NewsLook.com
Lack of Snow Pushes Alaska Sled Dog Race North

Lack of Snow Pushes Alaska Sled Dog Race North

AP (Mar. 6, 2015) — A shortage of snow has forced Alaska&apos;s Iditarod Trail Sled Dog Race to move 300 miles north to Fairbanks. The ceremonial start through downtown Anchorage will take place this weekend, using snow stockpiled earlier this winter. (March 6) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins