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A DEDD cert to support embryo development

Date:
December 6, 2010
Source:
Journal of Clinical Investigation
Summary:
Before the placenta is established, a structure that is key to supporting embryonic development forms in the uterus. Defective formation of this structure is thought to be a cause of female infertility. Researchers have now determined that the protein DEDD is required for the formation of this structure in mice and therefore suggest that it would be interesting to investigate whether DEDD dysfunction is the cause of infertility in some women.

The mammalian embryo relies on physical connections to its mother to survive. After implantation into the wall of the uterus and before the placenta is established, a structure known as the decidua forms and is key to supporting embryonic development. Defective formation of an effective decidua is thought to be a cause of female infertility.

A team of researchers, led by Toru Miyazaki, at the University of Tokyo, Japan, has now determined that the protein DEDD is required for the formation of a functional decidua in mice.

The authors therefore suggest that it would be interesting to investigate whether DEDD dysfunction is the cause of infertility in some women.

The research is published in the Journal of Clinical Investigation.


Story Source:

The above story is based on materials provided by Journal of Clinical Investigation. Note: Materials may be edited for content and length.


Journal Reference:

  1. mayumi Mori, Miwako Kitazume, Rui Ose, Jun Kurokawa, Kaori Koga, Yutaka Osuga, Satoko Arai and Toru Miyazaki. Death effector domain–containing protein (DEDD) is required for uterine decidualization during early pregnancy in mice. Journal of Clinical Investigation, 2010; DOI: 10.1172/JCI44723

Cite This Page:

Journal of Clinical Investigation. "A DEDD cert to support embryo development." ScienceDaily. ScienceDaily, 6 December 2010. <www.sciencedaily.com/releases/2010/12/101206135408.htm>.
Journal of Clinical Investigation. (2010, December 6). A DEDD cert to support embryo development. ScienceDaily. Retrieved July 28, 2014 from www.sciencedaily.com/releases/2010/12/101206135408.htm
Journal of Clinical Investigation. "A DEDD cert to support embryo development." ScienceDaily. www.sciencedaily.com/releases/2010/12/101206135408.htm (accessed July 28, 2014).

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