Featured Research

from universities, journals, and other organizations

Dengue fever virus' molecular secrets uncovered

Date:
March 8, 2011
Source:
American Institute of Physics
Summary:
Researchers are making major strides toward understanding the life cycle of flaviviruses, which include some of the most virulent human pathogens: yellow fever virus, Dengue virus and the West Nile Virus, among others.

Researchers at the Instituto de Medicina Molecular in Lisbon, Portugal and the Universidade Federal do Rio de Janeiro (UFRJ), Rio de Janeiro, Brazil, are making major strides toward understanding the life cycle of flaviviruses, which include some of the most virulent human pathogens: yellow fever virus, Dengue virus, and the West Nile Virus, among others.

At the 55th Annual Meeting of the Biophysical Society in Baltimore, MD on March 8, members of the team will report on studies using dengue virus as a model to elucidate the molecular details of the flavivirus life cycle -- work that may lead to new ways to fight Dengue virus infections, for which there are still no treatments and no effective preventative vaccines.

Dengue virus is one of the major causes of viral hemorrhagic fever worldwide, says Ivo Martins, a postdoctoral researcher in the group. About 40 percent of the world's population live in areas where this virus is transmitted. The World Health Organization estimates that 50-100 million people worldwide are infected with Dengue each year, and some 22,000 people die rom the virus -- mostly children.

Dengue virus is transmitted by the Aedes aegypti and Aedes albopictus mosquitoes, which are now found throughout the world, including in temperate regions such as the United States and France, where, in 2010, there were several cases of locally transmitted Dengue -- a disease that has been virtually unknown in these countries before.

"The burden that dengue infection (and other flaviviruses) poses on the economy and health systems of affected countries is considerable," says Martins. "Finding a dengue treatment, besides the obvious human health benefits, would thus benefit the economy in those countries immensely."

In Baltimore, Martins will discuss the group's use of biophysical techniques (nuclear magnetic resonance) combined with bioinformatics tools (genome sequence analysis) to elucidate the molecular details of interactions the Dengue virus capsid protein must make in order for it to replicate. In particular, the virus capsid protein must interact with intracellular lipid droplets in order for viral replication to be successful.


Story Source:

The above story is based on materials provided by American Institute of Physics. Note: Materials may be edited for content and length.


Cite This Page:

American Institute of Physics. "Dengue fever virus' molecular secrets uncovered." ScienceDaily. ScienceDaily, 8 March 2011. <www.sciencedaily.com/releases/2011/03/110308141059.htm>.
American Institute of Physics. (2011, March 8). Dengue fever virus' molecular secrets uncovered. ScienceDaily. Retrieved September 18, 2014 from www.sciencedaily.com/releases/2011/03/110308141059.htm
American Institute of Physics. "Dengue fever virus' molecular secrets uncovered." ScienceDaily. www.sciencedaily.com/releases/2011/03/110308141059.htm (accessed September 18, 2014).

Share This



More Plants & Animals News

Thursday, September 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Chimp Violence Study Renews Debate On Why They Kill

Chimp Violence Study Renews Debate On Why They Kill

Newsy (Sep. 17, 2014) The study weighs in on a debate over whether chimps are naturally violent or become that way due to human interference in the environment. Video provided by Newsy
Powered by NewsLook.com
Some Tobacco Farmers Thrive Amid Challenges

Some Tobacco Farmers Thrive Amid Challenges

AP (Sep. 16, 2014) The South's tobacco country is surviving, and even thriving in some cases, as demand overseas keeps growers in the fields of one of America's oldest cash crops. (Sept. 16) Video provided by AP
Powered by NewsLook.com
Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

Scientists Given Rare Glimpse of 350-Kilo Colossal Squid

AFP (Sep. 16, 2014) Scientists say a female colossal squid weighing an estimated 350 kilograms (770 lbs) and thought to be only the second intact specimen ever found was carrying eggs when discovered in the Antarctic. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Raw: Scientists Examine Colossal Squid

Raw: Scientists Examine Colossal Squid

AP (Sep. 16, 2014) Squid experts in New Zealand thawed and examined an unusual catch on Tuesday: a colossal squid. It was captured in Antarctica's remote Ross Sea in December last year and has been frozen for eight months. (Sept. 16) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins