Featured Research

from universities, journals, and other organizations

New understanding of chronic otitis media may inform future treatment

Date:
May 20, 2011
Source:
American Society for Microbiology
Summary:
In most children with chronic otitis media, biofilms laden with Haemophilus influenzae cling to the adenoids, while among a similar population suffering from obstructive sleep apnea, that pathogen is usually absent, according to new research.

In most children with chronic otitis media, biofilms laden with Haemophilus influenzae cling to the adenoids, while among a similar population suffering from obstructive sleep apnea, that pathogen is usually absent, according to a paper in the April 2011 Journal of Clinical Microbiology. This has major implications for treatment of chronic otitis media.

For one thing, biofilms are notoriously resistant to antibiotics. Earlier clinical studies had suggested that adenoids might be reservoirs for middle ear pathogens, and a 1987 study had suggested that adenoidectomy was effective in treating children prone to middle ear infections. Then, in 2006, Luanne Hall-Stoodley of the Wellcome Trust Clinical Research Facility, Southhampton, UK, et al. showed in children undergoing installation of tympanostomy tubes for treatment of chronic otitis media that the culprit bacteria inhabited biofilms attached to the middle ear mucosa, along with other bacteria that cause ear infections. "We therefore wondered if these pathogens might also form biofilms on the adenoid surface," says Hall-Stoodley.

To that end, this team of academic and clinical investigators used a device called the PlexID that can detect a broad range of bacteria in a clinical sample, and then used PCR and fluorescence in situ hybridization (FISH) probes to corroborate the presence of middle ear pathogens in the biofilms. That work fingered H. influenzae as the major culprit. "Clinically, our data explain why adenoidectomy helps with otitis media effusion since it removes a reservoir of pathogenic bacteria in the upper respiratory tract that can lead to otitis media," says Hall-Stoodley. That doesn't necessarily mean that clinicians will automatically recommend adenoidectomy as the primary surgical treatment, she adds. Nonetheless, "We are convinced that H. influenzae is a uniquely important pathogen in chronic otitis media," she says.

"I think that scientists have begun to think about chronic otitis media in a new way, and investigation of the pathogenesis of this complex disease will help in the design of novel therapies that do not depend on antibiotic treatment alone," says Hall-Stoodley. "Chronic middle ear infection can cause hearing impairment, which can affect verbal ability and education in children."

Hall-Stoodley notes that the use of bacterial culture to try to understand complex diseases such as otitis media has failed to provide a "complete understanding of the microbial complexity -- the microbiome -- that may be present in the nasopharynx," and that culture alone can no longer be the gold standard for identification of pathogens.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. L. Nistico, R. Kreft, A. Gieseke, J. M. Coticchia, A. Burrows, P. Khampang, Y. Liu, J. E. Kerschner, J. C. Post, S. Lonergan, R. Sampath, F. Z. Hu, G. D. Ehrlich, P. Stoodley, L. Hall-Stoodley. Adenoid Reservoir for Pathogenic Biofilm Bacteria. Journal of Clinical Microbiology, 2011; 49 (4): 1411 DOI: 10.1128/JCM.00756-10

Cite This Page:

American Society for Microbiology. "New understanding of chronic otitis media may inform future treatment." ScienceDaily. ScienceDaily, 20 May 2011. <www.sciencedaily.com/releases/2011/05/110516175342.htm>.
American Society for Microbiology. (2011, May 20). New understanding of chronic otitis media may inform future treatment. ScienceDaily. Retrieved July 31, 2014 from www.sciencedaily.com/releases/2011/05/110516175342.htm
American Society for Microbiology. "New understanding of chronic otitis media may inform future treatment." ScienceDaily. www.sciencedaily.com/releases/2011/05/110516175342.htm (accessed July 31, 2014).

Share This




More Health & Medicine News

Thursday, July 31, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

House Republicans Vote to Sue Obama Over Healthcare Law

House Republicans Vote to Sue Obama Over Healthcare Law

Reuters - US Online Video (July 31, 2014) The Republican-led House of Representatives votes to sue President Obama, accusing him of overstepping his executive authority in making changes to the Affordable Care Act. Mana Rabiee reports. Video provided by Reuters
Powered by NewsLook.com
Despite Health Questions, E-Cigs Are Beneficial: Study

Despite Health Questions, E-Cigs Are Beneficial: Study

Newsy (July 31, 2014) Citing 81 previous studies, new research out of London suggests the benefits of smoking e-cigarettes instead of regular ones outweighs the risks. Video provided by Newsy
Powered by NewsLook.com
Dangerous Bacteria Kills One in Florida

Dangerous Bacteria Kills One in Florida

AP (July 31, 2014) Sarasota County, Florida health officials have issued a warning against eating raw oysters and exposing open wounds to coastal and inland waters after a dangerous bacteria killed one person and made another sick. (July 31) Video provided by AP
Powered by NewsLook.com
Health Insurers' Profits Slide

Health Insurers' Profits Slide

Reuters - Business Video Online (July 30, 2014) Obamacare-related costs were said to be behind the profit plunge at Wellpoint and Humana, but Wellpoint sees the new exchanges boosting its earnings for the full year. Fred Katayama reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



    Save/Print:
    Share:

    Free Subscriptions


    Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

    Get Social & Mobile


    Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

    Have Feedback?


    Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
    Mobile: iPhone Android Web
    Follow: Facebook Twitter Google+
    Subscribe: RSS Feeds Email Newsletters
    Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins