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Scientists identify order of mutations that lead to cancer

Date:
June 30, 2011
Source:
American Association for Cancer Research
Summary:
Scientists have begun to reveal the order of the genetic aberrations in individual cancers in a finding they say is key to early diagnosis and personalized medicine.

Scientists have begun to reveal the order of the genetic aberrations in individual cancers in a finding they say is key to early diagnosis and personalized medicine.

"We know that each cancer is a collection of genetic malfunctions," said Raymond Cho, Ph.D., an assistant clinical professor in the department of dermatology at the University of California, San Francisco (UCSF). "We now show it is possible to determine which changes happen earlier and which ones happen further down the road, even in a single cancer."

Cho and colleagues reported the findings in Cancer Discovery, the newest journal of the American Association for Cancer Research. He said the work was the result of collaboration among UCSF, the Oregon Health & Science University, the University of California at Berkley and the Samsung Advanced Institute of Technology.

The researchers focused on TP53, a known oncogene present in cutaneous squamous cell carcinomas and serous ovarian adenocarcinomas. By examining how additional copies of the mutant oncogene accumulated, they found that complex changes in TP53 occurred earlier in most cases, rather than later, as had been previously believed.

According to the study, the ability to identify the actual sequence of mutations will help scientists to determine which mutations lead to precancerous lesions and which produce invasive carcinomas.

"Although cancers carry many mutations, the ones that always happen earliest set the stage for additional abnormalities," said Cho.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Journal Reference:

  1. S. Durinck, C. Ho, N. J. Wang, W. Liao, L. R. Jakkula, E. A. Collisson, J. Pons, S.-W. Chan, E. T. Lam, C. Chu, K. Park, S.-w. Hong, J. S. Hur, N. Huh, I. M. Neuhaus, S. S. Yu, R. C. Grekin, T. M. Mauro, J. E. Cleaver, P.-Y. Kwok, P. E. LeBoit, G. Getz, K. Cibulskis, J. C. Aster, H. Huang, E. Purdom, J. Li, L. Bolund, S. T. Arron, J. W. Gray, P. T. Spellman, R. J. Cho. Temporal Dissection of Tumorigenesis in Primary Cancers. Cancer Discovery, 2011; DOI: 10.1158/2159-8290.CD-11-0028

Cite This Page:

American Association for Cancer Research. "Scientists identify order of mutations that lead to cancer." ScienceDaily. ScienceDaily, 30 June 2011. <www.sciencedaily.com/releases/2011/06/110629132521.htm>.
American Association for Cancer Research. (2011, June 30). Scientists identify order of mutations that lead to cancer. ScienceDaily. Retrieved October 22, 2014 from www.sciencedaily.com/releases/2011/06/110629132521.htm
American Association for Cancer Research. "Scientists identify order of mutations that lead to cancer." ScienceDaily. www.sciencedaily.com/releases/2011/06/110629132521.htm (accessed October 22, 2014).

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