Featured Research

from universities, journals, and other organizations

Diet that combines cholesterol-lowering foods results in greater decrease in LDL than low-saturated fat diet, study finds

Date:
August 24, 2011
Source:
JAMA and Archives Journals
Summary:
Persons with high cholesterol who received counseling regarding a diet that combined cholesterol-lowering foods such as soy protein, nuts and plant sterols over six months experienced a greater reduction in their low-density lipoprotein cholesterol (LDL-C) levels than individuals who received advice on a low-saturated fat diet, according to a new study.

Persons with high cholesterol who received counseling regarding a diet that combined cholesterol-lowering foods such as soy protein, nuts and plant sterols over 6 months experienced a greater reduction in their low-density lipoprotein cholesterol (LDL-C) levels than individuals who received advice on a low-saturated fat diet, according to a study in the August 24/31 issue of JAMA.

Related Articles


Efforts have been made to improve the ability of conventional dietary therapy to reduce serum cholesterol through the inclusion of specific foods or food components with known cholesterol-lowering properties, singly or in combination (dietary portfolio), according to background information in the article. The long-term effect of such diets compared with conventional dietary advice has not previously been assessed.

David J. A. Jenkins, M.D., of St. Michael's Hospital and the University of Toronto, and colleagues conducted a multi-center trial to determine whether advice to eat a dietary portfolio consisting of foods recognized by the U.S. Food and Drug Administration as associated with lowering serum cholesterol achieved significantly greater percentage decreases in LDL-C levels compared with a control diet at 6-month follow-up. The control diet emphasized high fiber and whole grains but lacked components of the portfolio diet, which emphasized dietary incorporation of plant sterols, soy protein, viscous fibers, and nuts. The study included 351 participants with hyperlipidemia from 4 participating academic centers across Canada (Quebec City, Toronto, Winnipeg, and Vancouver) randomized between June 2007 and February 2009 to 1 of 3 treatments.

Participants received dietary advice for 6 months on either the low-saturated fat therapeutic diet (control) or a routine or intensive dietary portfolio, for which counseling was delivered at different frequencies. Routine dietary portfolio involved 2 clinic visits over 6 months and intensive dietary portfolio involved 7 clinic visits over 6 months.

In the modified intention-to-treat analysis of 345 participants, the overall attrition rate was not significantly different between treatments (18 percent for intensive dietary portfolio, 23 percent for routine dietary portfolio, and 26 percent for control).

The researchers found that the change in LDL-C levels from the beginning of the study to week 24 in the control diet were -3.0 percent or -8 mg/dL. In the routine and intensive dietary portfolio interventions, the respective percentage changes were -13.1 percent or -24 mg/dL and -13.8 percent or -26 mg/dL for LDL-C levels.

"Percentage LDL-C reductions for each dietary portfolio were significantly more than the control diet. The 2 dietary portfolio interventions did not differ significantly. Among participants randomized to one of the dietary portfolio interventions, percentage reduction in LDL-C on the dietary portfolio was associated with dietary adherence," the authors write.

"In conclusion, this study indicated the potential value of using recognized cholesterol-lowering foods in combination. We believe this approach has clinical application. A meaningful 13 percent LDL-C reduction can be obtained after only 2 clinic visits of approximately 60-and 40-minute sessions. The limited 3 percent LDL-C reduction observed in the conventional diet is likely to reflect the adequacy of the baseline diet and therefore suggests that larger absolute reductions in LDL-C may be observed when the dietary portfolio is prescribed to patients with diets more reflective of the general population," the authors write.


Story Source:

The above story is based on materials provided by JAMA and Archives Journals. Note: Materials may be edited for content and length.


Journal Reference:

  1. D. J. A. Jenkins, P. J. H. Jones, B. Lamarche, C. W. C. Kendall, D. Faulkner, L. Cermakova, I. Gigleux, V. Ramprasath, R. de Souza, C. Ireland, D. Patel, K. Srichaikul, S. Abdulnour, B. Bashyam, C. Collier, S. Hoshizaki, R. G. Josse, L. A. Leiter, P. W. Connelly, J. Frohlich. Effect of a Dietary Portfolio of Cholesterol-Lowering Foods Given at 2 Levels of Intensity of Dietary Advice on Serum Lipids in Hyperlipidemia: A Randomized Controlled Trial. JAMA: The Journal of the American Medical Association, 2011; 306 (8): 831 DOI: 10.1001/jama.2011.1202

Cite This Page:

JAMA and Archives Journals. "Diet that combines cholesterol-lowering foods results in greater decrease in LDL than low-saturated fat diet, study finds." ScienceDaily. ScienceDaily, 24 August 2011. <www.sciencedaily.com/releases/2011/08/110823165337.htm>.
JAMA and Archives Journals. (2011, August 24). Diet that combines cholesterol-lowering foods results in greater decrease in LDL than low-saturated fat diet, study finds. ScienceDaily. Retrieved November 24, 2014 from www.sciencedaily.com/releases/2011/08/110823165337.htm
JAMA and Archives Journals. "Diet that combines cholesterol-lowering foods results in greater decrease in LDL than low-saturated fat diet, study finds." ScienceDaily. www.sciencedaily.com/releases/2011/08/110823165337.htm (accessed November 24, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Monday, November 24, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Are Female Bosses More Likely To Be Depressed?

Are Female Bosses More Likely To Be Depressed?

Newsy (Nov. 24, 2014) A new study links greater authority with increased depressive symptoms among women in the workplace. Video provided by Newsy
Powered by NewsLook.com
Winter Can Cause Depression — Here's How To Combat It

Winter Can Cause Depression — Here's How To Combat It

Newsy (Nov. 23, 2014) Millions of American suffer from seasonal depression every year. It can lead to adverse health effects, but there are ways to ease symptoms. Video provided by Newsy
Powered by NewsLook.com
Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Don't Fall For Flu Shot Myths

Don't Fall For Flu Shot Myths

Newsy (Nov. 23, 2014) Misconceptions abound when it comes to your annual flu shot. Medical experts say most people older than 6 months should get the shot. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins