Featured Research

from universities, journals, and other organizations

Screening for HPV persistence and cervical cancer risk

Date:
September 6, 2011
Source:
Journal of the National Cancer Institute
Summary:
Women over the age of thirty who test positive for HPV (Human Papillomavirus) should be re-tested two years later as part of cervical cancer screening, according to a new study.

Women over the age of thirty who test positive for HPV (Human Papillomavirus) should be re-tested two years later as part of cervical cancer screening, according to a study published online TK in the Journal of the National Cancer Institute.

HPV infection is the main cause of cervical cancer, although most women infected with HPV do not have cervical pathology and most HPV infections in women under the age of 25 go away. Screening is recommended for women over age thirty, and the type of HPV strain to screen for is important, since only some are associated with cervical cancer risk. Furthermore, only persistently detectable infections seem to be associated with cervical cancer risk. However, few long-term studies have been done on the persistence of these infections and cervical cancer risk.

To determine the association between persistent HPV infections and cervical cancer risk in women over the age of thirty, Hui-Chi Chen, PhD, of the Genomics Research Center of Academia Sinica in Taipei, Taiwan, and colleagues, followed a cohort of 11,923 women aged 30-65 over a period of 16 years. The women underwent baseline exams that included HPV DNA testing and cytological tests, and the tests were repeated two years later. Incidence of cervical cancer was determined from cancer registries and death registries. In total, 6,666 women participated in both baseline and second visits, whereas the other 3,456 patients underwent only the first exam.

The researchers found that the 16-year risk of cervical cancer was 6.2% for women infected with any carcinogenic strains of the virus. Among women who were persistently infected with carcinogenic HPVs over the 2-year testing period, cervical cancer risk was 12.4%, whereas the risk was only 0.14% for women who repeatedly tested HPV negative. Since the duration of infection, rather than one-time infection, predicts cervical cancer risk, the researchers said it would not be useful to repeat HPV testing more frequently than every two years for HPV-positive women.

The authors write, "Our findings suggest that, if upon testing an HPV infection is found, re-testing 2 years later would provide useful guidance as to the duration of infection and its risk." Furthermore, they say, "The accumulated evidence suggests that it is time to include HPV testing in cancer screening programs for the general population."

The researchers add that genotyping may improve HPV testing since certain carcinogenic HPV strains -- namely HPV16 and HPV58 -- were associated with a higher risk of cervical cancer than others.

In an accompanying editorial, Kevin A. Ault, MD, of the Department of Gynecology and Obstetrics at Emory University School of Medicine notes that "persistent HPV infection is an intermediate step in the development of cervical cancer." He notes the study has several strengths, including long duration of follow-up, a large sample size, and linkage to the national cancer registry. He also adds that the study shows that women with negative HPV tests have a greatly reduced risk of developing cervical disease.


Story Source:

The above story is based on materials provided by Journal of the National Cancer Institute. Note: Materials may be edited for content and length.


Cite This Page:

Journal of the National Cancer Institute. "Screening for HPV persistence and cervical cancer risk." ScienceDaily. ScienceDaily, 6 September 2011. <www.sciencedaily.com/releases/2011/09/110906161626.htm>.
Journal of the National Cancer Institute. (2011, September 6). Screening for HPV persistence and cervical cancer risk. ScienceDaily. Retrieved April 18, 2014 from www.sciencedaily.com/releases/2011/09/110906161626.htm
Journal of the National Cancer Institute. "Screening for HPV persistence and cervical cancer risk." ScienceDaily. www.sciencedaily.com/releases/2011/09/110906161626.htm (accessed April 18, 2014).

Share This



More Health & Medicine News

Friday, April 18, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

'Holy Grail' Of Weight Loss? New Find Could Be It

'Holy Grail' Of Weight Loss? New Find Could Be It

Newsy (Apr. 18, 2014) In a potential breakthrough for future obesity treatments, scientists have used MRI scans to pinpoint brown fat in a living adult for the first time. Video provided by Newsy
Powered by NewsLook.com
Little Progress Made In Fighting Food Poisoning, CDC Says

Little Progress Made In Fighting Food Poisoning, CDC Says

Newsy (Apr. 18, 2014) A new report shows rates of two foodborne infections increased in the U.S. in recent years, while salmonella actually dropped 9 percent. Video provided by Newsy
Powered by NewsLook.com
Scientists Create Stem Cells From Adult Skin Cells

Scientists Create Stem Cells From Adult Skin Cells

Newsy (Apr. 17, 2014) The breakthrough could mean a cure for some serious diseases and even the possibility of human cloning, but it's all still a way off. Video provided by Newsy
Powered by NewsLook.com
Obama: 8 Million Healthcare Signups

Obama: 8 Million Healthcare Signups

AP (Apr. 17, 2014) President Barack Obama gave a briefing Thursday announcing 8 million people have signed up under the Affordable Care Act. He blasted continued Republican efforts to repeal the law. (April 17) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins