Featured Research

from universities, journals, and other organizations

Small molecule hobbles dengue in vitro and in vivo

Date:
September 19, 2011
Source:
American Society for Microbiology
Summary:
A novel compound inhibits dengue virus, as well as other closely related important human pathogens, according to new research.

A novel compound inhibits dengue virus, as well as other closely related important human pathogens. The research is published in the September 2011 issue of the journal Antimicrobial Agents and Chemotherapy.

Related Articles


Dengue virus causes an estimated about 50 million infections annually, resulting in half a million hospitalizations, and a 2.5 percent mortality rate, according to the World Health Organization. Neither antivirus therapy nor vaccines exist against dengue. The newly discovered inhibitor is also active against fellow flavivirus family members including West Nile virus, yellow fever virus, Japanese encephalitis virus, and tick-borne encephalitis virus. The compound works by preventing translation of RNA to protein, according to the report.

In the study, the researchers identified the small molecule inhibitor via high throughput screening of Novartis compound libraries, says corresponding author, Pei-Yong Shi of Novartis Institute for Tropical Diseases, Singapore. They then refined the original molecule to give it greater metabolic stability. Tests in a dengue mouse viremia model showed that "this compound significantly reduced peak viremia, demonstrating the in vivo efficacy of the inhibitor," according to the report.

However, despite the fact that the compound selectively inhibits protein translation in flaviviruses, in in vitro tests, it nonselectively inhibited viral and host translation. That raised the specter of side effects, and indeed, tripling the experimental dose in the mouse model caused significant side effects, according to the report. Thus, the therapeutic window needs to be widened before the compound will be ready for clinical testing, the researchers report.

The compound is being developed under the auspices of the Novartis Institute for Tropical Diseases, which aims to develop novel therapeutics for neglected diseases, and to provide these new medicines to poor patients at cost prices," says Shi. "Dengue poses a public health threat to 2.5 billion people worldwide," most of them living in poverty or near poverty.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. Q.-Y. Wang, R. R. Kondreddi, X. Xie, R. Rao, S. Nilar, H. Y. Xu, M. Qing, D. Chang, H. Dong, F. Yokokawa, S. B. Lakshminarayana, A. Goh, W. Schul, L. Kramer, T. H. Keller, P.-Y. Shi. A Translation Inhibitor That Suppresses Dengue Virus In Vitro and In Vivo. Antimicrobial Agents and Chemotherapy, 2011; 55 (9): 4072 DOI: 10.1128/AAC.00620-11

Cite This Page:

American Society for Microbiology. "Small molecule hobbles dengue in vitro and in vivo." ScienceDaily. ScienceDaily, 19 September 2011. <www.sciencedaily.com/releases/2011/09/110919113411.htm>.
American Society for Microbiology. (2011, September 19). Small molecule hobbles dengue in vitro and in vivo. ScienceDaily. Retrieved April 21, 2015 from www.sciencedaily.com/releases/2011/09/110919113411.htm
American Society for Microbiology. "Small molecule hobbles dengue in vitro and in vivo." ScienceDaily. www.sciencedaily.com/releases/2011/09/110919113411.htm (accessed April 21, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Tuesday, April 21, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deepwater And Dolphins: The Oil Spill's Impact 5 Years On

Deepwater And Dolphins: The Oil Spill's Impact 5 Years On

Newsy (Apr. 20, 2015) Five years on, the possible environmental impact of the Deepwater Horizon spill includes a sustained die-off of bottlenose dolphins, among others. Video provided by Newsy
Powered by NewsLook.com
Five Years Later, the BP Oil Spill Is Still Taking Its Toll

Five Years Later, the BP Oil Spill Is Still Taking Its Toll

AFP (Apr. 20, 2015) On April 20, 2010, an explosion and fire on the Deepwater Horizon rig in the Gulf of Mexico started the biggest oil spill in US history. BP recently reported the Gulf is recovering well, but scientists paint a different picture. Duration: 02:36 Video provided by AFP
Powered by NewsLook.com
Thai Customs Seize African Elephant Tusks Worth $6 Mn

Thai Customs Seize African Elephant Tusks Worth $6 Mn

AFP (Apr. 20, 2015) Thai customs seize four tonnes of African elephant ivory worth $6 million at a Bangkok port in a container labelled as beans. Duration: 00:47 Video provided by AFP
Powered by NewsLook.com
Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Un-Bee-Lievable: Bees on the Loose After Washington Truck Crash

Reuters - US Online Video (Apr. 17, 2015) A truck carrying honey bees overturns near Lynnwood, Washington, spreading boxes of live bees across the highway. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins