Featured Research

from universities, journals, and other organizations

Probiotics appear to mitigate pancreatitis: Surprising hypothetical mechanism warrants further investigation

Date:
November 16, 2011
Source:
American Society for Microbiology
Summary:
A probiotic treatment appears to mitigate pancreatitis in an animal model, leading to a new hypothesis of how probiotics may act, according to a new study. The bacterial species most closely associated with improvement in health was discovered for the first time in the course of this research.

A probiotic treatment appears to mitigate pancreatitis in an animal model, leading to a new hypothesis of how probiotics may act, according to a paper in the November Applied and Environmental Microbiology. The bacterial species most closely associated with improvement in health was discovered for the first time in the course of this research.

Related Articles


Severe acute pancreatitis is a critical illness that is characterized by intestinal barrier dysfunction. While it is usually self-limiting, in 20 to 30 percent of cases patients develop serious disease, including systemic inflammatory response syndrome, sepsis, and/or multiple organ dysfunction, which frequently cause death.

In this study, Jacoline Gerritsen of University Medical Center, Utrecht, the Netherlands, and her collaborators gave one group of rats probiotic on a daily basis, beginning five days before they induced acute pancreatitis, and continuing briefly afterwards, before they sacrificed the animals. Another set of rats received a placebo.

The major finding: in the small intestine, higher than normal numbers of the newly discovered bacterium, "commensal rat ileum bacterium" (CRIB) were correlated with reduced severity of acute pancreatitis in animals that had been fed probiotic. These animals had less infection of remote organs, less infection of dying and dead pancreatic tissues, and less severe immune response during acute pancreatitis, as demonstrated by lower plasma levels of proinflammatory cytokines. CRIB, a member of the genus Clostridium, is not a constituent of the probiotic (Ecologic 641), but rather a benign bacterium that normally inhabits the lower gut. "…these results suggest that effects of this multispecies probiotic mixture… are mediated by stimulation of a not previously described gut commensal bacterium… which protects the host from severe sepsis," according to the report.

"This research has provided new knowledge on the possible mechanisms behind probiotic action," says Gerritsen. "In addition, it shows that bacterial species inhabiting the small intestine might be very important for health. Up until now, medical researchers have neglected the small intestine, because it is very difficult to obtain such samples from humans." That needs to change, she says.


Story Source:

The above story is based on materials provided by American Society for Microbiology. Note: Materials may be edited for content and length.


Journal Reference:

  1. J. Gerritsen, H. M. Timmerman, S. Fuentes, L. P. van Minnen, H. Panneman, S. R. Konstantinov, F. M. Rombouts, H. G. Gooszen, L. M. A. Akkermans, H. Smidt, G. T. Rijkers. Correlation between Protection against Sepsis by Probiotic Therapy and Stimulation of a Novel Bacterial Phylotype. Applied and Environmental Microbiology, 2011; 77 (21): 7749 DOI: 10.1128/AEM.05428-11

Cite This Page:

American Society for Microbiology. "Probiotics appear to mitigate pancreatitis: Surprising hypothetical mechanism warrants further investigation." ScienceDaily. ScienceDaily, 16 November 2011. <www.sciencedaily.com/releases/2011/11/111116192955.htm>.
American Society for Microbiology. (2011, November 16). Probiotics appear to mitigate pancreatitis: Surprising hypothetical mechanism warrants further investigation. ScienceDaily. Retrieved January 31, 2015 from www.sciencedaily.com/releases/2011/11/111116192955.htm
American Society for Microbiology. "Probiotics appear to mitigate pancreatitis: Surprising hypothetical mechanism warrants further investigation." ScienceDaily. www.sciencedaily.com/releases/2011/11/111116192955.htm (accessed January 31, 2015).

Share This


More From ScienceDaily



More Plants & Animals News

Saturday, January 31, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Nanoscale Sensor Could Help Wine Producers and Clinical Scientists

Reuters - Innovations Video Online (Jan. 30, 2015) A nanosensor that mimics the oral effects and sensations of drinking wine has been developed by Danish and Portuguese researchers. Jim Drury saw it in operation. Video provided by Reuters
Powered by NewsLook.com
Dog-Loving Astronaut Wins Best Photo of 2015

Dog-Loving Astronaut Wins Best Photo of 2015

Buzz60 (Jan. 30, 2015) Retired astronaut and television host, Leland Melvin, snuck his dogs into the NASA studio so they could be in his official photo. As Mara Montalbano (@maramontalbano) shows us, the secret is out. Video provided by Buzz60
Powered by NewsLook.com
U.S. Wants to Analyze DNA from 1 Million People

U.S. Wants to Analyze DNA from 1 Million People

Reuters - US Online Video (Jan. 30, 2015) The U.S. has proposed analyzing genetic information from more than 1 million American volunteers to learn how genetic variants affect health and disease. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Rarest Cat on Planet Caught Attacking Monkeys on Camera

Rarest Cat on Planet Caught Attacking Monkeys on Camera

Buzz60 (Jan. 30, 2015) An African Golden Cat, the rarest large cat on the planet was recently caught on camera by scientists trying to study monkeys. The cat comes out of nowhere to attack those monkeys. Patrick Jones (@Patrick_E_Jones) has the rest. Video provided by Buzz60
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins