Featured Research

from universities, journals, and other organizations

Study of two sisters sheds light on lymphoma evolution

Date:
December 12, 2011
Source:
American Association for Cancer Research
Summary:
A woman received a transplant from her sister to treat leukemia. Both sisters later developed lymphoma, suggesting transfer of a common ancestor. Finding gives scientists new insight into lymphoma development.

When a 41-year-old woman was diagnosed with chronic-phase chronic myeloid leukemia, she received a bone marrow transplant and subsequent leukocyte infusion from her sister. These treatments controlled her leukemia, but seven years later, both sisters developed follicular lymphoma.

Although the phenomenon of a donor passing a malignancy to a recipient is well documented and considered a minimal risk to those in the transplant community, this case gave scientists the unique opportunity to understand the genetic abnormalities that led to follicular lymphoma in both cases.

"We were able to combine clinical activity with laboratory expertise to gain a real insight into the biology involved," said David Weinstock, M.D., an assistant professor of medicine at Dana-Farber Cancer Institute, who published the case study in a recent issue of Cancer Discovery, the newest journal of the American Association for Cancer Research.

The study was funded by a Stand Up To Cancer Innovative Research Grant.

Both sisters are now in remission after standard chemotherapy treatment. Weinstock's research group will present their findings at the 2011 American Society of Hematology Annual Meeting and Exposition in San Diego on Dec. 12, 2011.

Weinstock and his colleagues sequenced the DNA of samples derived from the two sisters as well as a frozen sample of the leukocyte infusion to determine the genetic lesions that led to the lymphoma.

They found that both sisters had identical BCL2/IGH rearrangements and the same V(D)J rearrangement. They also identified 15 mutations that were present in both lymphomas. Researchers recovered 14 of these mutations from the donor lymphocyte infusions using ultra-deep sequencing -- a finding that indicates that a lymphoma ancestor harboring these mutations was passed from the donor to the recipient seven years before clinical presentation.

Weinstock said this sort of knowledge could one day lead to an early treatment for follicular lymphoma.

"Currently the only curative approach is stem cell transplantation, but the more we understand about the genetic aberrations that lead to follicular lymphoma, the better we'll be able to manage the disease," said Weinstock.


Story Source:

The above story is based on materials provided by American Association for Cancer Research. Note: Materials may be edited for content and length.


Cite This Page:

American Association for Cancer Research. "Study of two sisters sheds light on lymphoma evolution." ScienceDaily. ScienceDaily, 12 December 2011. <www.sciencedaily.com/releases/2011/12/111212132630.htm>.
American Association for Cancer Research. (2011, December 12). Study of two sisters sheds light on lymphoma evolution. ScienceDaily. Retrieved July 29, 2014 from www.sciencedaily.com/releases/2011/12/111212132630.htm
American Association for Cancer Research. "Study of two sisters sheds light on lymphoma evolution." ScienceDaily. www.sciencedaily.com/releases/2011/12/111212132630.htm (accessed July 29, 2014).

Share This




More Health & Medicine News

Tuesday, July 29, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deadly Ebola Virus Threatens West Africa

Deadly Ebola Virus Threatens West Africa

AP (July 28, 2014) West African nations and international health organizations are working to contain the largest Ebola outbreak in history. It's one of the deadliest diseases known to man, but the CDC says it's unlikely to spread in the U.S. (July 28) Video provided by AP
Powered by NewsLook.com
$15B Deal on Vets' Health Care Reached

$15B Deal on Vets' Health Care Reached

AP (July 28, 2014) A bipartisan deal to improve veterans health care would authorize at least $15 billion in emergency spending to fix a veterans program scandalized by long patient wait times and falsified records. (July 28) Video provided by AP
Powered by NewsLook.com
Two Americans Contract Ebola in Liberia

Two Americans Contract Ebola in Liberia

Reuters - US Online Video (July 28, 2014) Two American aid workers in Liberia test positive for Ebola while working to combat the deadliest outbreak of the virus ever. Linda So reports. Video provided by Reuters
Powered by NewsLook.com
Traditional African Dishes Teach Healthy Eating

Traditional African Dishes Teach Healthy Eating

AP (July 28, 2014) Classes are being offered nationwide to encourage African Americans to learn about cooking fresh foods based on traditional African cuisine. The program is trying to combat obesity, heart disease and other ailments often linked to diet. (July 28) Video provided by AP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins