Featured Research

from universities, journals, and other organizations

Age-related degeneration can be caused by defects of energy metabolism in tissue stem cells

Date:
January 3, 2012
Source:
Helsingin yliopisto (University of Helsinki)
Summary:
New findings increase the understanding of mechanisms of age-related degeneration. The results are a breakthrough in revealing the unexpected importance of energy metabolism in regulating stem cell function and tissue maintenance.

New findings by researchers at the University of Helsinki, Finland, increase the understanding of mechanisms of age-related degeneration. The results are a breakthrough in revealing the unexpected importance of energy metabolism in regulating stem cell function and tissue maintenance.

Related Articles


Age-related tissue degeneration can be caused by mitochondrial dysfunction in tissue stem cells. The research group of Professor Anu Suomalainen Wartiovaara at the University of Helsinki, with their collaborators in Max Planck Institute for Biology of Aging, Karolinska Institutet and University of Wisconsin, reported on the 3rd January in Cell Metabolism their results on mechanisms of age-associated degeneration.

Stem cells are called the spare parts for tissues, as they maintain and repair tissues during life. They are multipotent and can produce a variety of different cell types, from blood cells to neurons and skin cells. Mitochondria are the cellular engine: they transform the energy of nutrients to a form that cells can use, and in this process they burn most of the inhaled oxygen. If this nutrient 'burning' is inefficient, the engine will produce exhaust fumes, oxygen radicals, which damage cellular structures, including the genome. Antioxidants target to scavenge these radicals.

Already in 2004 and 2005 a research model was created in Sweden and USA, which accumulated a heavy load of mitochondrial genome defects. This led to symptoms of premature aging: thin skin, graying of hair, baldness, osteoporosis and anemia.

In the current publication, scientist Kati Ahlqvist in Professor Suomalainen Wartiovaara's group showed that these symptoms were partially explained by stem cell dysfunction. The number of stem cells did not reduce, but their function was modified: the progeny cells in blood and the nervous system were dysfunctional. The researchers also found out that these defects could be partially prevented by early antioxidant treatment.

"This suggests that oxygen radicals can regulate stem cell function and that these cells are very susceptible for mitochondrial dysfunction. These findings may also be important to understand mechanisms of mitochondrial disease," Professor Suomalainen Wartiovaara says.

The results are a breakthrough in revealing the unexpected importance of energy metabolism in regulating stem cell function and tissue maintenance. These findings increase the understanding of mechanisms of age-related degeneration.


Story Source:

The above story is based on materials provided by Helsingin yliopisto (University of Helsinki). Note: Materials may be edited for content and length.


Journal Reference:

  1. ati Ahlqvist, Riikka H Hämäläinen, Shuichi Yatsuga, Marko Uutela, Mügen Terzioglu, Alexandra Götz, Saara Forsström, Petri Salven, Alexandre Angers-Loustau, Outi H Kopra, Henna Tyynismaa, Nils-Göran Larsson, Kirmo Wartiovaara, Tomas Prolla, Aleksandra Trifunovic, Anu Suomalainen. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metabolism, 3 Jan 2012

Cite This Page:

Helsingin yliopisto (University of Helsinki). "Age-related degeneration can be caused by defects of energy metabolism in tissue stem cells." ScienceDaily. ScienceDaily, 3 January 2012. <www.sciencedaily.com/releases/2012/01/120103134917.htm>.
Helsingin yliopisto (University of Helsinki). (2012, January 3). Age-related degeneration can be caused by defects of energy metabolism in tissue stem cells. ScienceDaily. Retrieved November 26, 2014 from www.sciencedaily.com/releases/2012/01/120103134917.htm
Helsingin yliopisto (University of Helsinki). "Age-related degeneration can be caused by defects of energy metabolism in tissue stem cells." ScienceDaily. www.sciencedaily.com/releases/2012/01/120103134917.htm (accessed November 26, 2014).

Share This


More From ScienceDaily



More Health & Medicine News

Wednesday, November 26, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Pet Dogs to Be Used in Anti-Ageing Trial

Pet Dogs to Be Used in Anti-Ageing Trial

Reuters - Innovations Video Online (Nov. 26, 2014) — Researchers in the United States are preparing to discover whether a drug commonly used in human organ transplants can extend the lifespan and health quality of pet dogs. Video provided by Reuters
Powered by NewsLook.com
From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

From Popcorn To Vending Snacks: FDA Ups Calorie Count Rules

Newsy (Nov. 25, 2014) — The US FDA is announcing new calorie rules on Tuesday that will require everywhere from theaters to vending machines to include calorie counts. Video provided by Newsy
Powered by NewsLook.com
Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Daily Serving Of Yogurt Could Reduce Risk Of Type 2 Diabetes

Newsy (Nov. 25, 2014) — Need another reason to eat yogurt every day? Researchers now say it could reduce a person's risk of developing type 2 diabetes. Video provided by Newsy
Powered by NewsLook.com
Madagascar Working to Contain Plague Outbreak

Madagascar Working to Contain Plague Outbreak

AFP (Nov. 24, 2014) — Madagascar said Monday it is trying to contain an outbreak of plague -- similar to the Black Death that swept Medieval Europe -- that has killed 40 people and is spreading to the capital Antananarivo. Duration: 00:42 Video provided by AFP
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins