Featured Research

from universities, journals, and other organizations

Age-related degeneration can be caused by defects of energy metabolism in tissue stem cells

Date:
January 3, 2012
Source:
Helsingin yliopisto (University of Helsinki)
Summary:
New findings increase the understanding of mechanisms of age-related degeneration. The results are a breakthrough in revealing the unexpected importance of energy metabolism in regulating stem cell function and tissue maintenance.

New findings by researchers at the University of Helsinki, Finland, increase the understanding of mechanisms of age-related degeneration. The results are a breakthrough in revealing the unexpected importance of energy metabolism in regulating stem cell function and tissue maintenance.

Related Articles


Age-related tissue degeneration can be caused by mitochondrial dysfunction in tissue stem cells. The research group of Professor Anu Suomalainen Wartiovaara at the University of Helsinki, with their collaborators in Max Planck Institute for Biology of Aging, Karolinska Institutet and University of Wisconsin, reported on the 3rd January in Cell Metabolism their results on mechanisms of age-associated degeneration.

Stem cells are called the spare parts for tissues, as they maintain and repair tissues during life. They are multipotent and can produce a variety of different cell types, from blood cells to neurons and skin cells. Mitochondria are the cellular engine: they transform the energy of nutrients to a form that cells can use, and in this process they burn most of the inhaled oxygen. If this nutrient 'burning' is inefficient, the engine will produce exhaust fumes, oxygen radicals, which damage cellular structures, including the genome. Antioxidants target to scavenge these radicals.

Already in 2004 and 2005 a research model was created in Sweden and USA, which accumulated a heavy load of mitochondrial genome defects. This led to symptoms of premature aging: thin skin, graying of hair, baldness, osteoporosis and anemia.

In the current publication, scientist Kati Ahlqvist in Professor Suomalainen Wartiovaara's group showed that these symptoms were partially explained by stem cell dysfunction. The number of stem cells did not reduce, but their function was modified: the progeny cells in blood and the nervous system were dysfunctional. The researchers also found out that these defects could be partially prevented by early antioxidant treatment.

"This suggests that oxygen radicals can regulate stem cell function and that these cells are very susceptible for mitochondrial dysfunction. These findings may also be important to understand mechanisms of mitochondrial disease," Professor Suomalainen Wartiovaara says.

The results are a breakthrough in revealing the unexpected importance of energy metabolism in regulating stem cell function and tissue maintenance. These findings increase the understanding of mechanisms of age-related degeneration.


Story Source:

The above story is based on materials provided by Helsingin yliopisto (University of Helsinki). Note: Materials may be edited for content and length.


Journal Reference:

  1. ati Ahlqvist, Riikka H Hämäläinen, Shuichi Yatsuga, Marko Uutela, Mügen Terzioglu, Alexandra Götz, Saara Forsström, Petri Salven, Alexandre Angers-Loustau, Outi H Kopra, Henna Tyynismaa, Nils-Göran Larsson, Kirmo Wartiovaara, Tomas Prolla, Aleksandra Trifunovic, Anu Suomalainen. Somatic progenitor cell vulnerability to mitochondrial DNA mutagenesis underlies progeroid phenotypes in Polg mutator mice. Cell Metabolism, 3 Jan 2012

Cite This Page:

Helsingin yliopisto (University of Helsinki). "Age-related degeneration can be caused by defects of energy metabolism in tissue stem cells." ScienceDaily. ScienceDaily, 3 January 2012. <www.sciencedaily.com/releases/2012/01/120103134917.htm>.
Helsingin yliopisto (University of Helsinki). (2012, January 3). Age-related degeneration can be caused by defects of energy metabolism in tissue stem cells. ScienceDaily. Retrieved January 27, 2015 from www.sciencedaily.com/releases/2012/01/120103134917.htm
Helsingin yliopisto (University of Helsinki). "Age-related degeneration can be caused by defects of energy metabolism in tissue stem cells." ScienceDaily. www.sciencedaily.com/releases/2012/01/120103134917.htm (accessed January 27, 2015).

Share This


More From ScienceDaily



More Health & Medicine News

Tuesday, January 27, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Mistakes Should Serve a Lesson Says WHO

Ebola Mistakes Should Serve a Lesson Says WHO

AFP (Jan. 25, 2015) — The World Health Organization&apos;s chief on Sunday admitted the UN agency had been caught napping on Ebola, saying it should serve a lesson to avoid similar mistakes in future. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Disneyland Measles Outbreak Spreads To 5 States

Disneyland Measles Outbreak Spreads To 5 States

Newsy (Jan. 24, 2015) — Much of the Disneyland measles outbreak is being blamed on the anti-vaccination movement. The CDC encourages just about everyone get immunized. Video provided by Newsy
Powered by NewsLook.com
Growing Measles Outbreak Worries Calif. Parents

Growing Measles Outbreak Worries Calif. Parents

AP (Jan. 23, 2015) — Public health officials are rushing to contain a measles outbreak that has sickened 70 people across 6 states and Mexico. The AP&apos;s Raquel Maria Dillon has more. (Jan. 23) Video provided by AP
Powered by NewsLook.com
Smart Wristband to Shock Away Bad Habits

Smart Wristband to Shock Away Bad Habits

Reuters - Innovations Video Online (Jan. 23, 2015) — A Boston start-up is developing a wristband they say will help users break bad habits by jolting them with an electric shock. Ben Gruber reports. Video provided by Reuters
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
 
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:  

Breaking News:

Strange & Offbeat Stories

 

Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:  

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile iPhone Android Web
Follow Facebook Twitter Google+
Subscribe RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins