Featured Research

from universities, journals, and other organizations

Secret of sperm quality control revealed

Date:
February 16, 2012
Source:
Yale University
Summary:
Researchers have discovered how the "guardian of the genome'' oversees quality control in the production of sperm -- and perhaps in many other cells as well.

Yale researchers have discovered how the "guardian of the genome'' oversees quality control in the production of sperm -- and perhaps in many other cells as well.

The research published online Feb. 16 in the journal Current Biology opens up the potential of developing new forms of birth control and fertility treatment -- and even new ways to combat many forms of cancer.

Sperm and other cells go through a sort of inspection process triggered by a key regulatory gene, p53, which orders the destruction of cells with damaged DNA. This ability has earned it the title of "guardian of the genome," and damage to p53 has been implicated in many forms of cancer.

By studying sperm production in mice, "we have identified p53's new boss, which controls p53 in a way that had been hypothesized before but had not been shown in any animal," said Haifan Lin, professor of cell biology and of genetics, director of the Yale Stem Cell Center, and senior author of the paper.

The Yale team found among more than 1,500 micro-RNA molecules involved in many cellular processes, a regulator called Pumilo 1 controls eight that interact with p53 in sperm production. When Pumilo 1 is deleted in mice, sperm production and fertility are reduced because p53 becomes over active and orders the destruction of too many sperm. The mechanism may play a key role in male fertility, but it could also be implicated in many biological processes because protection of DNA is so fundamental to life, Lin noted.

"This is a crucial gate-keeping mechanism which allows bad cells, but not good cells, to be killed," Lin said. "This same process may be at play in other tissues, such as cancer."

Dong Chen was lead author of the study. Wei Zheng, Aiping Lin, Katherine Uyhazi, and Hongyu Zhao are other contributing authors from Yale.

The research was funded by the National Institutes of Health (NIH) and supported by the Yale Clinical and Translational Science Award grant from the National Center for Advancing Translational Sciences at the NIH.


Story Source:

The above story is based on materials provided by Yale University. The original article was written by Bill Hathaway. Note: Materials may be edited for content and length.


Journal Reference:

  1. Dong Chen, Wei Zheng, Aiping Lin, Katherine Uyhazi, Hongyu Zhao, Haifan Lin. Pumilio 1 Suppresses Multiple Activators of p53 to Safeguard Spermatogenesis. Current Biology, 2012; DOI: 10.1016/j.cub.2012.01.039

Cite This Page:

Yale University. "Secret of sperm quality control revealed." ScienceDaily. ScienceDaily, 16 February 2012. <www.sciencedaily.com/releases/2012/02/120216133432.htm>.
Yale University. (2012, February 16). Secret of sperm quality control revealed. ScienceDaily. Retrieved October 2, 2014 from www.sciencedaily.com/releases/2012/02/120216133432.htm
Yale University. "Secret of sperm quality control revealed." ScienceDaily. www.sciencedaily.com/releases/2012/02/120216133432.htm (accessed October 2, 2014).

Share This



More Health & Medicine News

Thursday, October 2, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola Might Not Be Out Of Control In U.S., But Coverage Is

Ebola Might Not Be Out Of Control In U.S., But Coverage Is

Newsy (Oct. 2, 2014) Coverage of the lone Ebola patient discovered in Texas has U.S. media in a frenzy — but does the coverage match the reality? Video provided by Newsy
Powered by NewsLook.com
US Hunts Contacts of Ebola Patient, Including Children

US Hunts Contacts of Ebola Patient, Including Children

AFP (Oct. 2, 2014) Health officials in Texas on Wednesday scoured the Dallas area for people, including schoolchildren, who came in contact with a Liberian man who was diagnosed with Ebola in the United States. Duration: 00:55 Video provided by AFP
Powered by NewsLook.com
Study Says Losing Sense Of Smell Can Indicate Death

Study Says Losing Sense Of Smell Can Indicate Death

Newsy (Oct. 2, 2014) Researchers found elderly adults with a poor sense of smell are more likely to die within five years. Video provided by Newsy
Powered by NewsLook.com
Pregnancy Spacing Could Have Big Impact On Autism Risks

Pregnancy Spacing Could Have Big Impact On Autism Risks

Newsy (Oct. 1, 2014) A new study says children born less than one year and more than five years after a sibling can have an increased risk for autism. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Health & Medicine

Mind & Brain

Living & Well

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins