Featured Research

from universities, journals, and other organizations

Delayed female sexual maturity linked to longer lifespan in mice

Date:
May 7, 2012
Source:
Jackson Laboratory
Summary:
Female mice from strains with lower IGF1 levels reach sexual maturity at a significantly later age. Combined with previous research showing that mouse strains with lower circulating levels of IGF1 live longer, the findings suggest a genetically regulated tradeoff: delayed reproduction but longer life.

An intriguing clue to longevity lurks in the sexual maturation timetable of female mammals, Jackson Laboratory researchers and their collaborators report.

Related Articles


Jackson researchers including Research Scientist Rong Yuan, Ph.D., had previously established that mouse strains with lower circulating levels of the hormone IGF1 at age six months live longer than other strains. In research published May 7 in the Proceedings of the National Academy of Sciences, Yuan and colleagues report that females from strains with lower IGF1 levels also reach sexual maturity at a significantly later age.

"This suggests a genetically regulated tradeoff -- delayed reproduction but longer life -- that is at least partially mediated by IGF1," Yuan says.

The researchers conclude that IGF1 may co-regulate female sexual maturation and longevity. They showed that mouse strains derived from wild populations carry specific gene variants that delay sexual maturation, and they identified a candidate gene, Nrip1, involved in regulating sexual maturation that may also affect longevity by controlling IGF1 levels.

Yuan notes that researchers in England recently showed that higher levels of IGF1 and other hormones in girls are associated with earlier age of menarche (onset of menstruation). In the newly published research, Yuan and colleagues used the biological benchmark of vaginal patency (VP) as indicator of sexual maturity in female mice.

Mice from the inbred strain C57BL/6J, also known as "Black 6," showed 9 percent lower IGF1, 6 percent delayed age of VP and 24 percent extended lifespan compared to a Black 6 substrain that carries a gene variation that increases IGF1.

Using a technique called haplotype mapping, the researchers screened genetic and physiological data for 31 different inbred mouse strains and found genes that regulate female sexual maturation and lifespan, on Chromosomes 4 and 16. They showed that wild-derived mouse strains share a genetic profile associated with delayed VP and increased longevity, and identified a candidate gene, Nrip1, that controls IGF1 and age of VP.

Yuan is a research scientist in the laboratory of Professor Luanne Peters and a member of the leadership team for the Aging Center at The Jackson Laboratory.


Story Source:

The above story is based on materials provided by Jackson Laboratory. Note: Materials may be edited for content and length.


Journal Reference:

  1. Rong Yuan, Qingying Meng, Jaya Nautiyal, Kevin Flurkey, Shirng-Wern Tsaih, Rebecca Krier, Malcolm G. Parker, David E. Harrison, and Beverly Paigen. Genetic coregulation of age of female sexual maturation and lifespan through circulating IGF1 among inbred mouse strains. PNAS, May 7, 2012 DOI: 10.1073/pnas.1121113109

Cite This Page:

Jackson Laboratory. "Delayed female sexual maturity linked to longer lifespan in mice." ScienceDaily. ScienceDaily, 7 May 2012. <www.sciencedaily.com/releases/2012/05/120507154103.htm>.
Jackson Laboratory. (2012, May 7). Delayed female sexual maturity linked to longer lifespan in mice. ScienceDaily. Retrieved October 25, 2014 from www.sciencedaily.com/releases/2012/05/120507154103.htm
Jackson Laboratory. "Delayed female sexual maturity linked to longer lifespan in mice." ScienceDaily. www.sciencedaily.com/releases/2012/05/120507154103.htm (accessed October 25, 2014).

Share This



More Plants & Animals News

Saturday, October 25, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Deep Sea 'mushroom' Could Be Early Branch on Tree of Life

Reuters - Innovations Video Online (Oct. 24, 2014) Miniature deep sea animals discovered off the Australian coast almost three decades ago are puzzling scientists, who say the organisms have proved impossible to categorise. Academics at the Natural History of Denmark have appealed to the world scientific community for help, saying that further information on Dendrogramma enigmatica and Dendrogramma discoides could answer key evolutionary questions. Jim Drury has more. Video provided by Reuters
Powered by NewsLook.com
Black Bear Cub Goes Sunday Shopping

Black Bear Cub Goes Sunday Shopping

Reuters - Light News Video Online (Oct. 23, 2014) Price check on honey? Bear cub startles Oregon drugstore shoppers. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Dances With Wolves in China's Wild West

Dances With Wolves in China's Wild West

AFP (Oct. 23, 2014) One man is on a mission to boost the population of wolves in China's violence-wracked far west. The animal - symbol of the Uighur minority there - is under threat with a massive human resettlement program in the region. Duration: 00:41 Video provided by AFP
Powered by NewsLook.com
Breakfast Debate: To Eat Or Not To Eat?

Breakfast Debate: To Eat Or Not To Eat?

Newsy (Oct. 23, 2014) Conflicting studies published in the same week re-ignited the debate over whether we should be eating breakfast. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins