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Revealing the stars of brain adaptability

Date:
May 16, 2012
Source:
RIKEN
Summary:
Star-shaped brain cells called astrocytes are found to bridge the gap between global brain activity and localized circuits. Global network activity in the brain modulates local neural circuitry via calcium signaling in non-neuronal cells called astrocytes, according to new research.

Astrocytes are star-shaped cells with numerous fine projections that ensheath synapses in the brain.
Credit: 2012 Hajime Hirase

Star-shaped brain cells called astrocytes are found to bridge the gap between global brain activity and localized circuits. Global network activity in the brain modulates local neural circuitry via calcium signaling in non-neuronal cells called astrocytes, according to research led by Hajime Hirase of the RIKEN Brain Science Institute.

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The finding clarifies the link between two important processes in the brain.

Activity in large-scale brain networks is thought to modulate changes in neuronal connectivity, so-called 'synaptic plasticity', in the cerebral cortex. The neurotransmitter acetylcholine regulates global brain activity associated with attention and awareness, and is involved in plasticity.

To investigate how these processes are linked, Hirase and his colleagues simultaneously stimulated the whiskers of mice and the nucleus basalis of Meynert (NBM), a basal forebrain structure containing neurons that synthesize acetylcholine and project widely to the cortex. Using electrodes and an imaging technique called two-photon microscopy, performed through a 'cranial window', they monitored the responses of cells in the barrel cortex, which receives inputs from the whiskers.

Recordings from the electrodes showed that repeated co-stimulation of the whiskers and NBM induced plasticity in the barrel cortex. This plasticity depended on two types of receptors -- muscarinic acetylcholine receptors (mAChRs) and N-methyl-D-aspartic acid receptors (NMDARs). Two-photon imaging microscopy further revealed that activation of the mAChRs during co-stimulation elevated the concentration of calcium ions within astrocytes of the barrel cortex.

The researchers repeated these experiments in mutant mice lacking the receptor that controls the release of calcium ions in astrocytes. Since co-stimulation of whiskers and NBM did not induce plasticity in the mutants, Hirase and colleagues concluded that calcium signaling in astrocytes acts as a 'gate' linking the changes in global brain state induced by acetylcholine to activity in local cortical circuits.

Furthermore, the researchers found that stimulation of the NBM led to an increase in the extracellular concentration of the amino acid D-serine in the normal, but not the mutant, mice. D-serine is secreted by astrocytes and activates NMDARs. Hirase's team had previously shown that astrocytes are electrically silent in living rodents even in the presence of neural activity. The new findings showed that the biochemical, as opposed to electrical, activation of astrocytes induces them to release the transmitter that modulates synaptic plasticity in the neuronal circuitry.

"Our study is probably the first to show that calcium signaling in astrocytes is related to neuronal circuit plasticity in living animals," says Hirase. "We are now studying if this type of calcium signaling occurs in all parts of an astrocyte or is restricted to some parts of the cell."


Story Source:

The above story is based on materials provided by RIKEN. Note: Materials may be edited for content and length.


Journal References:

  1. N. Takata, T. Mishima, C. Hisatsune, T. Nagai, E. Ebisui, K. Mikoshiba, H. Hirase. Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo. Journal of Neuroscience, 2011; 31 (49): 18155 DOI: 10.1523/JNEUROSCI.5289-11.2011
  2. N. Takata, T. Mishima, C. Hisatsune, T. Nagai, E. Ebisui, K. Mikoshiba, H. Hirase. Astrocyte Calcium Signaling Transforms Cholinergic Modulation to Cortical Plasticity In Vivo. Journal of Neuroscience, 2011; 31 (49): 18155 DOI: 10.1523/JNEUROSCI.5289-11.2011

Cite This Page:

RIKEN. "Revealing the stars of brain adaptability." ScienceDaily. ScienceDaily, 16 May 2012. <www.sciencedaily.com/releases/2012/05/120516092555.htm>.
RIKEN. (2012, May 16). Revealing the stars of brain adaptability. ScienceDaily. Retrieved November 27, 2014 from www.sciencedaily.com/releases/2012/05/120516092555.htm
RIKEN. "Revealing the stars of brain adaptability." ScienceDaily. www.sciencedaily.com/releases/2012/05/120516092555.htm (accessed November 27, 2014).

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