Featured Research

from universities, journals, and other organizations

Type of viral infection of eye associated with disease causing blindness in the elderly

Date:
May 21, 2012
Source:
Georgia State University
Summary:
Scientists have found that a type of herpesvirus infection of the eye is associated with neovascular age-related macular degeneration, a disease that causes blindness in the elderly.

A team of researchers, including a scientist from the Viral Immunology Center at Georgia State University, have found that a type of herpesvirus infection of the eye is associated with neovascular age-related macular degeneration (AMD), a disease that causes blindness in the elderly.

The scientists found that human cytomegalovirus, a type of herpesvirus, causes the production of vascular endothelial growth factor, or VEGF, a signal protein that regulates the formation of new blood vessels.

With the formation of new blood vessels, retinal tissue destruction occurs, leading to the development of "wet" AMD and eventually, vision loss and blindness. The results were published in PLoS Pathogens, a journal of the Public Library of Science.

"Prior to this work, cofactors for the development of AMD included genetics, a high fat diet and smoking. Now, we are adding an infections agent as another cofactor," said Richard D. Dix, professor at the Georgia State Viral Immunology Center's Ocular Virology and Immunology Laboratory.

The research team includes Dix, Scott W. Cousins, Diego G. Espinosa-Heidmann, Daniel M. Miller, Simone Pereira-Simon, Eleut P. Hernandez, Hsin Chien and Courtney Meier-Jewett.

Affiliated research institutions include the Duke University Eye Center, the Bascom Palmer Eye Institute of the University of Miami Miller School of Medicine, the Viral Immunology Center at Georgia State, and the Department of Ophthalmology at the Emory University School of Medicine.

Human cytomegalovirus is a common herpesvirus, said Dix, who is also an adjunct professor of ophthalmology at the Emory University School of Medicine. About 80 percent of the population is estimated to have antibodies for the virus, and it is often acquired during childhood.

If a person has a normal, healthy immune system, the virus becomes latent in the cells of bone marrow and blood, he said. But in the elderly, the immune system's function is reduced, the virus proliferates, and the production of VEGF increases.

Identifying human cytomegalovirus as a cofactor in the development of AMD opens up new paths for the treatment of AMD, Dix said. One route could include reducing the viral load -- the amount of the human cytomegalovirus in the blood stream -- by treatment with an antiviral drug known as ganciclovir.

Additional research paths include looking at the genetics involved in the upregulation of VEGF by human cytomegalovirus.

"If we can knock down a certain gene or genes of the virus that stimulates VEGF production, we might be able to decrease it production and minimize AMD," Dix said.


Story Source:

The above story is based on materials provided by Georgia State University. Note: Materials may be edited for content and length.


Journal Reference:

  1. Scott W. Cousins, Diego G. Espinosa-Heidmann, Daniel M. Miller, Simone Pereira-Simon, Eleut P. Hernandez, Hsin Chien, Courtney Meier-Jewett, Richard D. Dix. Macrophage Activation Associated with Chronic Murine Cytomegalovirus Infection Results in More Severe Experimental Choroidal Neovascularization. PLoS Pathogens, 2012; 8 (4): e1002671 DOI: 10.1371/journal.ppat.1002671

Cite This Page:

Georgia State University. "Type of viral infection of eye associated with disease causing blindness in the elderly." ScienceDaily. ScienceDaily, 21 May 2012. <www.sciencedaily.com/releases/2012/05/120521164149.htm>.
Georgia State University. (2012, May 21). Type of viral infection of eye associated with disease causing blindness in the elderly. ScienceDaily. Retrieved August 27, 2014 from www.sciencedaily.com/releases/2012/05/120521164149.htm
Georgia State University. "Type of viral infection of eye associated with disease causing blindness in the elderly." ScienceDaily. www.sciencedaily.com/releases/2012/05/120521164149.htm (accessed August 27, 2014).

Share This




More Health & Medicine News

Wednesday, August 27, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Predicting Heart Transplant Rejection With a Blood Test

Predicting Heart Transplant Rejection With a Blood Test

Ivanhoe (Aug. 27, 2014) Now a new approach to rejection of donor organs could change the way doctors predict transplant rejection…without expensive, invasive procedures. Video provided by Ivanhoe
Powered by NewsLook.com
Better Braces That Vibrate

Better Braces That Vibrate

Ivanhoe (Aug. 27, 2014) The length of time you have to keep your braces on could be cut in half thanks to a new device that speeds up the process. Video provided by Ivanhoe
Powered by NewsLook.com
Smartphone App Tracks Your Heart Rate

Smartphone App Tracks Your Heart Rate

Ivanhoe (Aug. 27, 2014) A new app that can track your heart rate 24/7 is available for download in your app store and its convenience could save your life. Video provided by Ivanhoe
Powered by NewsLook.com
Stroke in Young Adults

Stroke in Young Adults

Ivanhoe (Aug. 27, 2014) A stroke can happen at any time and affect anyone regardless of age. This mother chose to give her son independence and continue to live a normal life after he had a stroke at 18 years old. Video provided by Ivanhoe
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins