Featured Research

from universities, journals, and other organizations

Arsenic for better drugs and cleaner crops

Date:
June 25, 2012
Source:
University of Gothenburg
Summary:
New research may lead to more effective arsenic-containing drugs. The results may also lead to more resistant plants, and crops with a limited absorption and storage of arsenic.

Research carried out at the University of Gothenburg may lead to more effective arsenic-containing drugs. The results may also lead to more resistant plants, and crops with a limited absorption and storage of arsenic.

Related Articles


Even though arsenic is toxic for many organs in the human body, it is used in the treatment of some forms of cancer, and it is an active component of drugs against parasitic diseases.

Healing arsenic

Arsenic is used in therapeutic medicine, but we know relatively little about the mechanisms by which cells develop resistance to arsenic, which may lead to a lower therapeutic effect.

Proteins control cellular processes

Scientist Doryaneh Ahmadpour at the Department of Chemistry and Molecular Biology, University of Gothenburg, has carried out experiments with common baker's yeast, in order to find out how inflow and outflow take place in cells.

"The knowledge we obtain from determining these mechanisms in yeast can be subsequently used in the long term to produce more effective drugs containing arsenic. A membrane protein known as Fps1 is particularly interesting. This protein transports the trivalent form of arsenic (arsenite) into and out from the cell," says Doryaneh Ahmadpour.

She has worked with scientist Michael Thorsen to show how the Fps1 protein is regulated and how the inflow into the cell of arsenic is influenced by another protein, Hog1.

The results suggest that a reduction in the activity of Hog1 is an effective way of increasing the ability of the cell to absorb arsenic. This may make the cell more sensitive to arsenic and thus give more effective treatment.

Resistance to arsenic can be increased in a similar manner, by increasing the activity of Hog1, which reduces the inflow of arsenic into the cells.

"We have shown also that a protein known as Slt2 regulates the outflow of arsenic from the cell, and increases the resistance of the cell to arsenic. It is possible, in the same way, to regulate the cellular resistance against arsenic by controlling the activity of Slt2."

Arsenic as a problem

Arsenic is a toxic metalloid that is naturally found in earth crust. It can be leached out by water or spread by industrial activity.

Arsenic is a global problem due to the increasing contamination of water, soil and crops, not only in the industrialized world but also in developing countries.

"High levels of arsenic in groundwater can lead to humans being exposed to toxic levels in food and water. This affects mainly people in regions in which the crops are watered with arsenic-contaminated water, leading to arsenic being stored in the plants."

Resistant crops

Increased knowledge about arsenic can be used to produce plants with a high absorption, and these can be used to clean contaminated land. The knowledge can also be used to produce food crops, known as "safe crops," with a limited absorption and storage of arsenic.

The thesis has been successfully defended.


Story Source:

The above story is based on materials provided by University of Gothenburg. Note: Materials may be edited for content and length.


Cite This Page:

University of Gothenburg. "Arsenic for better drugs and cleaner crops." ScienceDaily. ScienceDaily, 25 June 2012. <www.sciencedaily.com/releases/2012/06/120625085312.htm>.
University of Gothenburg. (2012, June 25). Arsenic for better drugs and cleaner crops. ScienceDaily. Retrieved January 26, 2015 from www.sciencedaily.com/releases/2012/06/120625085312.htm
University of Gothenburg. "Arsenic for better drugs and cleaner crops." ScienceDaily. www.sciencedaily.com/releases/2012/06/120625085312.htm (accessed January 26, 2015).

Share This


More From ScienceDaily



More Earth & Climate News

Monday, January 26, 2015

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Florida Might Legalize Black Bear Hunting

Florida Might Legalize Black Bear Hunting

Newsy (Jan. 24, 2015) A string of black bear attacks has Florida officials considering lifting the ban on hunting the animals to control their population. Video provided by Newsy
Powered by NewsLook.com
Dramatic Footage Shows Coast Guard Rescue Off Scottish Coast

Dramatic Footage Shows Coast Guard Rescue Off Scottish Coast

Reuters - News Video Online (Jan. 23, 2015) Footage just released by the UK Coast Guard shows a dramatic helicopter rescue off the Scottish coast, where five men were plucked to safety after their fishing boat sank on Saturday. Rough Cut (no reporter narration). Video provided by Reuters
Powered by NewsLook.com
Stunning Wingsuit Proximity Flying in Norway

Stunning Wingsuit Proximity Flying in Norway

Rumble (Jan. 23, 2015) A collection of amazing shots from flights made in the Aurland Valley in Norway. How incredible is that? Credit to &apos;BASEjumper&apos;. Video provided by Rumble
Powered by NewsLook.com
Senate Agrees Climate Change Is Happening, Just Not On Why

Senate Agrees Climate Change Is Happening, Just Not On Why

Newsy (Jan. 22, 2015) The Senate voted to confirm climate change is real, but some still weren&apos;t on board with the idea that humans are causing it. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins