Featured Research

from universities, journals, and other organizations

'Flightless' molecule may prevent cancer from spreading from one tissue to another

Date:
July 31, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
Thanks to the "flightless" molecule, the spread of cancer from one tissue to another may one day be grounded. Laboratory experiments show that "flightless" (named after its effects on fruit flies) increases the "stickiness" that causes cells, including cancer cells, to attach to underlying tissue, which in turn, slows their movement throughout the body.

New research shows that a molecule called 'flightless' significantly helps control the speed with which cells move through various tissues.

Thanks to the "flightless" molecule, the spread of cancer from one tissue to another may one day be grounded. In a new report published in the August 2012 print issue of The FASEB Journal laboratory experiments show that "flightless" (named after its effects on fruit flies) increases the "stickiness" that causes cells, including cancer cells, to attach to underlying tissue, which in turn, slows their movement throughout the body.

"The study of flightless and its role in the control of cell movement offers the promise of developing new drugs and treatments to control diseases in which cell movement has gotten out of control," said Christopher A. McCulloch, from Matrix Dynamics Group at the University of Toronto in Canada. "We hope that one day treatments to regulate cell movement could be used to bring under better control the spread of cancer cells from a tumor into the rest of the body."

To make this discovery, scientists used three groups of cells that made either normal amounts of flightless, or were genetically modified to produce no flightless, or to make above-normal amounts of flightless. Researchers then studied the rate of movement of these different groups of cells and examined the specialized parts of cells that enable them to stick to tissues. When the stickiness of the cells to underlying tissues was examined, results showed that flightless had a marked effect on how quickly cells could detach from underlying tissues and move forward in response to stimuli that encourage them to migrate.

"Fighting a single tumor in one organ is hard, but the fact that many cancers metastasize adds new obstacles to treatment," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This report on 'flightless' is an important first step toward to preventing cancers from taking off to other parts of the body."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. I. Mohammad, P. D. Arora, Y. Naghibzadeh, Y. Wang, J. Li, W. Mascarenhas, P. A. Janmey, J. F. Dawson, C. A. McCulloch. Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration. The FASEB Journal, 2012; 26 (8): 3260 DOI: 10.1096/fj.11-202051

Cite This Page:

Federation of American Societies for Experimental Biology. "'Flightless' molecule may prevent cancer from spreading from one tissue to another." ScienceDaily. ScienceDaily, 31 July 2012. <www.sciencedaily.com/releases/2012/07/120731103033.htm>.
Federation of American Societies for Experimental Biology. (2012, July 31). 'Flightless' molecule may prevent cancer from spreading from one tissue to another. ScienceDaily. Retrieved April 16, 2014 from www.sciencedaily.com/releases/2012/07/120731103033.htm
Federation of American Societies for Experimental Biology. "'Flightless' molecule may prevent cancer from spreading from one tissue to another." ScienceDaily. www.sciencedaily.com/releases/2012/07/120731103033.htm (accessed April 16, 2014).

Share This



More Health & Medicine News

Wednesday, April 16, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Could Even Casual Marijuana Use Alter Your Brain?

Could Even Casual Marijuana Use Alter Your Brain?

Newsy (Apr. 16, 2014) A new study conducted by researchers at Northwestern and Harvard suggests even casual marijuana use can alter your brain. Video provided by Newsy
Powered by NewsLook.com
Ebola Outbreak Now Linked To 121 Deaths

Ebola Outbreak Now Linked To 121 Deaths

Newsy (Apr. 15, 2014) The ebola virus outbreak in West Africa is now linked to 121 deaths. Health officials fear the virus will continue to spread in urban areas. Video provided by Newsy
Powered by NewsLook.com
Cognitive Function: Is It All Downhill From Age 24?

Cognitive Function: Is It All Downhill From Age 24?

Newsy (Apr. 15, 2014) A new study out of Canada says cognitive motor performance begins deteriorating around age 24. Video provided by Newsy
Powered by NewsLook.com
How Mt. Everest Helped Scientists Research Diabetes

How Mt. Everest Helped Scientists Research Diabetes

Newsy (Apr. 15, 2014) British researchers were able to use Mount Everest's low altitudes to study insulin resistance. They hope to find ways to treat diabetes. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:
from the past week

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins