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'Flightless' molecule may prevent cancer from spreading from one tissue to another

Date:
July 31, 2012
Source:
Federation of American Societies for Experimental Biology
Summary:
Thanks to the "flightless" molecule, the spread of cancer from one tissue to another may one day be grounded. Laboratory experiments show that "flightless" (named after its effects on fruit flies) increases the "stickiness" that causes cells, including cancer cells, to attach to underlying tissue, which in turn, slows their movement throughout the body.

New research shows that a molecule called 'flightless' significantly helps control the speed with which cells move through various tissues.

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Thanks to the "flightless" molecule, the spread of cancer from one tissue to another may one day be grounded. In a new report published in the August 2012 print issue of The FASEB Journal laboratory experiments show that "flightless" (named after its effects on fruit flies) increases the "stickiness" that causes cells, including cancer cells, to attach to underlying tissue, which in turn, slows their movement throughout the body.

"The study of flightless and its role in the control of cell movement offers the promise of developing new drugs and treatments to control diseases in which cell movement has gotten out of control," said Christopher A. McCulloch, from Matrix Dynamics Group at the University of Toronto in Canada. "We hope that one day treatments to regulate cell movement could be used to bring under better control the spread of cancer cells from a tumor into the rest of the body."

To make this discovery, scientists used three groups of cells that made either normal amounts of flightless, or were genetically modified to produce no flightless, or to make above-normal amounts of flightless. Researchers then studied the rate of movement of these different groups of cells and examined the specialized parts of cells that enable them to stick to tissues. When the stickiness of the cells to underlying tissues was examined, results showed that flightless had a marked effect on how quickly cells could detach from underlying tissues and move forward in response to stimuli that encourage them to migrate.

"Fighting a single tumor in one organ is hard, but the fact that many cancers metastasize adds new obstacles to treatment," said Gerald Weissmann, M.D., Editor-in-Chief of The FASEB Journal. "This report on 'flightless' is an important first step toward to preventing cancers from taking off to other parts of the body."


Story Source:

The above story is based on materials provided by Federation of American Societies for Experimental Biology. Note: Materials may be edited for content and length.


Journal Reference:

  1. I. Mohammad, P. D. Arora, Y. Naghibzadeh, Y. Wang, J. Li, W. Mascarenhas, P. A. Janmey, J. F. Dawson, C. A. McCulloch. Flightless I is a focal adhesion-associated actin-capping protein that regulates cell migration. The FASEB Journal, 2012; 26 (8): 3260 DOI: 10.1096/fj.11-202051

Cite This Page:

Federation of American Societies for Experimental Biology. "'Flightless' molecule may prevent cancer from spreading from one tissue to another." ScienceDaily. ScienceDaily, 31 July 2012. <www.sciencedaily.com/releases/2012/07/120731103033.htm>.
Federation of American Societies for Experimental Biology. (2012, July 31). 'Flightless' molecule may prevent cancer from spreading from one tissue to another. ScienceDaily. Retrieved December 19, 2014 from www.sciencedaily.com/releases/2012/07/120731103033.htm
Federation of American Societies for Experimental Biology. "'Flightless' molecule may prevent cancer from spreading from one tissue to another." ScienceDaily. www.sciencedaily.com/releases/2012/07/120731103033.htm (accessed December 19, 2014).

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