Featured Research

from universities, journals, and other organizations

Fitting Kv potassium channels in the PIP2 puzzle

Date:
August 27, 2012
Source:
Rockefeller University Press
Summary:
A recent study brings new insights to an area of ion channel regulation: whether voltage-gated potassium (Kv) channels can be regulated by physiological changes to PIP2.

A recent JGP study brings new insights to an area of ion channel regulation: whether voltage-gated potassium (Kv) channels can be regulated by physiological changes to PIP2 (shown here), a minor phospholipid component of cell membranes that binds to various membrane proteins and modulates their activity.
Credit: Adler, E.M. 2012. J. Gen. Physiol. doi:10.1085/jgp.201210877 (image created with Jmol)

A recent study in the Journal of General Physiology brings new insights to an area of ion channel regulation: whether voltage-gated potassium (Kv) channels can be regulated by physiological changes to PIP2.

Related Articles


Potassium channels, microscopic pores that allow potassium ions to cross cell membranes, are crucial to such diverse processes as conduction of the nerve impulse, regulation of the heartbeat, and the secretion of hormones such as insulin. PIP2, a minor phospholipid component of cell membranes, regulates the activity of various proteins in the cell membrane, and previous studies have indicated that it might be a very important regulator of such channels.

To probe the cell signaling roles of PIP2 under physiological conditions, Bertil Hille (University of Washington) and colleagues used a set of sophisticated molecular tools to rapidly deplete PIP2 in the membranes of intact cells and simultaneously monitor the PIP2 changes that occurred.

Using this approach, they confirmed previous studies showing that the activity of "inward rectifier" potassium channels was strongly dependent on PIP2. Surprisingly, however, they found that various members of the Kv channel family thought to be PIP2 sensitive on the basis of studies that analyzed their activity in isolated patches of cell membrane were, in fact, unaffected by PIP2 depletion. Thus, the group demonstrated that large PIP2 changes at the membranes of intact cells did not modulate the function of these Kv channels, contrary to expectations.

According to Donald Hilgemann (UT Southwestern Medical Center at Dallas) in commentary appearing in the September 2012 issue of JGP, the findings are an important step forward in our understanding of PIP2 effects on Kv channels. Furthermore, the tools employed by the Hille group can now be used to address questions about PIP2 functions in other cellular processes. In addition to its complex roles in cytoskeleton regulation and endocytosis, PIP2 appears to influence many cell membrane processes, including the formation of membrane domains, membrane budding, and membrane turnover.


Story Source:

The above story is based on materials provided by Rockefeller University Press. Note: Materials may be edited for content and length.


Journal Reference:

  1. E. M. Adler. Of receptors, channels, and watching the red cell center lose hold. The Journal of General Physiology, 2012; 140 (3): 243 DOI: 10.1085/jgp.201210877

Cite This Page:

Rockefeller University Press. "Fitting Kv potassium channels in the PIP2 puzzle." ScienceDaily. ScienceDaily, 27 August 2012. <www.sciencedaily.com/releases/2012/08/120827122414.htm>.
Rockefeller University Press. (2012, August 27). Fitting Kv potassium channels in the PIP2 puzzle. ScienceDaily. Retrieved November 23, 2014 from www.sciencedaily.com/releases/2012/08/120827122414.htm
Rockefeller University Press. "Fitting Kv potassium channels in the PIP2 puzzle." ScienceDaily. www.sciencedaily.com/releases/2012/08/120827122414.htm (accessed November 23, 2014).

Share This


More From ScienceDaily



More Plants & Animals News

Sunday, November 23, 2014

Featured Research

from universities, journals, and other organizations


Featured Videos

from AP, Reuters, AFP, and other news services

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

Ebola-Hit Sierra Leone's Late Cocoa Leaves Bitter Taste

AFP (Nov. 23, 2014) The arable district of Kenema in Sierra Leone -- at the centre of the Ebola outbreak in May -- has been under quarantine for three months as the cocoa harvest comes in. Duration: 01:32 Video provided by AFP
Powered by NewsLook.com
Anglerfish Rarely Seen In Its Habitat Will Haunt You

Anglerfish Rarely Seen In Its Habitat Will Haunt You

Newsy (Nov. 22, 2014) For the first time Monterey Bay Aquarium recorded a video of the elusive, creepy and rarely seen anglerfish. Video provided by Newsy
Powered by NewsLook.com
Birds Around the World Take Flight

Birds Around the World Take Flight

Reuters - Light News Video Online (Nov. 22, 2014) An imperial eagle equipped with a camera spreads its wings over London. It's just one of the many birds making headlines in this week's "animal roundup". Jillian Kitchener reports. Video provided by Reuters
Powered by NewsLook.com
Could Your Genes Be The Reason You're Single?

Could Your Genes Be The Reason You're Single?

Newsy (Nov. 21, 2014) Researchers in Beijing discovered a gene called 5-HTA1, and carriers are reportedly 20 percent more likely to be single. Video provided by Newsy
Powered by NewsLook.com

Search ScienceDaily

Number of stories in archives: 140,361

Find with keyword(s):
Enter a keyword or phrase to search ScienceDaily for related topics and research stories.

Save/Print:
Share:

Breaking News:

Strange & Offbeat Stories


Plants & Animals

Earth & Climate

Fossils & Ruins

In Other News

... from NewsDaily.com

Science News

Health News

Environment News

Technology News



Save/Print:
Share:

Free Subscriptions


Get the latest science news with ScienceDaily's free email newsletters, updated daily and weekly. Or view hourly updated newsfeeds in your RSS reader:

Get Social & Mobile


Keep up to date with the latest news from ScienceDaily via social networks and mobile apps:

Have Feedback?


Tell us what you think of ScienceDaily -- we welcome both positive and negative comments. Have any problems using the site? Questions?
Mobile: iPhone Android Web
Follow: Facebook Twitter Google+
Subscribe: RSS Feeds Email Newsletters
Latest Headlines Health & Medicine Mind & Brain Space & Time Matter & Energy Computers & Math Plants & Animals Earth & Climate Fossils & Ruins